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THE BIOASSAY OF THYROTROPIN IN SERUM1
Abstract
A bioassay technique for thyrotropin in serum was developed from that of Adams and Purves. Mice were injected with I131 and then had endogenous thyrotropin suppressed by the administration of thyroxine followed by thyroid powder. The effect of an intravenous injection of thyrotropin or the test sub-stance was measured by the percentage increase in blood I131. This had a linear relationship to the logarithm of the dose. Sensitivity of 0.025 mu., with an injec-tion volume of 0.5 ml., and an average index of precision (λ) of 0.24 were achieved With this technique thyrotropin in the sera of 6 patients with myxedema was measured. Endogenous thyrotropic activity was shown to travel on electrophoresis with gamma globulin of such sera and was also present only in the gamma globulin fraction (II) of Cohn fractions of human plasma.
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Citations
Cited by
THYROID-STIMULATING IMMUNOGLOBULINS IN GRAVES' DISEASE
SMITH, B. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91815-7 · Cited by 567
The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies*
Rapoport, B., Chazenbalk, G. D., Jaume, J. C., & McLachlan, S. M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.6.0352 · Cited by 551
Utility of the Radioimmunoassay of Serum Thyrotrophin in Man
HERSHMAN, J. M., & PITTMAN, J. A. (1971) · Annals of Internal Medicine · doi:10.7326/0003-4819-74-4-481 · Cited by 159
Tissue-specific posttranslational modification allows functional targeting of thyrotropin
Ikegami, K., Liao, X.-H., Hoshino, Y., Ono, H., Ota, W., Ito, Y., Nishiwaki-Ohkawa, T., Sato, C., Kitajima, K., Iigo, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.006 · Cited by 102
Consiglio, E., Salvatore, G., Rall, J. E., & Kohn, L. D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50561-5 · Cited by 98
Metadata
- Authors
- McKENZIE, J. M.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1958-09
- Volume
- 63
- Issue
- 3
- Pages
- 372-382
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2113537773
- Cited by
- 431
- References
- 0
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- McKENZIE, J. M. (1958). THE BIOASSAY OF THYROTROPIN IN SERUM1. Endocrinology. https://doi.org/10.1210/endo-63-3-372
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
