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Cited by 159Thyroid Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and Treatments

Utility of the Radioimmunoassay of Serum Thyrotrophin in Man

HERSHMAN, JEROME M., PITTMAN, JAMES A.·1971·Annals of Internal Medicine
DOI 10.7326/0003-4819-74-4-481
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Abstract

The normal human serum thyrotrophin (TSH) measured by a double antibody radioimmunoassay was 3.9 ± 2.0 (SD) µunits/ml. It was markedly elevated in 61 patients with primary hypothyroidism and undetectable in 10 with hypothyroidism secondary to hypopituitarism and in 23 hyperthyroid patients. There was no significant diurnal variation of serum TSH and no increase after cold exposure of adult men for 1 hr or after electroconvulsive, vasopressin, or glucagon therapy. The level was normal in patients with Cushing's syndrome and acromegaly and in pregnant women at term. The serum TSH of newborns exceeded the maternal level significantly and rose to very high values at 1 hr of age. Because of the stability of serum TSH levels in adults, an elevated level is good indication of primary hypothyroidism. Injection of synthetic thyrotrophin-releasing factor (500 to 1,000 µg) caused marked elevation of serum TSH; the response to 10 mg given orally was more prolonged. Synthetic thyrotrophin-releasing factor should be a useful agent for clinical assessment of pituitary TSH reserve.

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Crossref · 10.7326/0003-4819-74-4-481

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Authors
HERSHMAN, J. M., & PITTMAN, J. A.
Affiliations
Birmingham, Alabama
Corresponding author
HERSHMAN, JEROME M.
Venue
Annals of Internal Medicine
Publisher
American College of Physicians
Published
1971-04-01
Volume
74
Issue
4
Pages
481-490
ISSN
  • 0003-4819 (ISSN-L)
  • 1539-3704
DOI
10.7326/0003-4819-74-4-481
OpenAlex
W1971459605
Cited by
159
References
40
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2021: 3 · 2019: 1 · 2016: 1 · 2015: 2 · 2013: 2
FWCI
32.08
Type
journal article
Language
en
Open access
closed
Licence
www.acpjournals.org/journal/aim/text-and-data-mining (tdm)
Locations
  • Annals of Internal Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
serum thyrotropin, TSH radioimmunoassay, primary hypothyroidism, central hypothyroidism, hypopituitarism, hyperthyroidism, thyrotropin-releasing hormone, neonates, Cushing's syndrome, acromegaly, pregnancy, diurnal variation, cold exposure
MeSH terms
Acromegaly, Adenoma, Chromophobe, Adult, Biological Assay, Circadian Rhythm, Cold Temperature, Cushing Syndrome, Electroconvulsive Therapy, Female, Humans, Hyperthyroidism, Hypothyroidism, Infant, Newborn, Iodine Isotopes, Male, Middle Aged, Myxedema, Pituitary Gland, Pituitary Neoplasms, Pregnancy, Radioimmunoassay, Thyrotropin, Thyrotropin-Releasing Hormone

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