The DOI matches its Crossref record.
Neurohypophysial Principles in Rats Homozygous and Heterozygous for Hypothalamic Diabetes Insipidus (Brattleboro Strain)
Abstract
Extracts of pituitary glands and hypothalami from rats with hereditary hypothalamic diabetes insipidus (DI), from rats heterozygous for the DI trait, and from normal rats have been assayed for neurohypophysial principles. Eleven of 12 rats with DI appeared to have no vasopressin in their pituitaries and little or none in their hypothalami. Their pituitary content of oxytocin was about 1/3 of normal. In heterozygotes, vasopressin content was reduced: to about 2/3 of normal in pituitaries and to 1/7 of normal in hypothalami. Pituitary content of oxytocin was normal in heterozygotes. The data strongly suggest that DI rats have an absolute, and heterozygotes a partial, genetic defect for synthesizing vasopressin. Oxytocin synthesis appears to be unimpaired in both DI and heterozygous rats. (Endocrinology77: 701, 1965)
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor
Land, H., Schütz, G., Schmale, H., & Richter, D. (1982) · Nature · doi:10.1038/295299a0 · Cited by 569
Gene Regulation in the Magnocellular Hypothalamo-Neurohypophysial System
Burbach, J. P. H., Luckman, S. M., Murphy, D., & Gainer, H. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1197 · Cited by 340
Activity-dependent neuronal-glial and synaptic plasticity in the adult mammalian hypothalamus
Theodosis, D. T., & Poulain, D. A. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90002-w · Cited by 276
Modulatory effects of vasopressin on glucose and protein metabolism during food-restriction stress
Wideman, C. H., & Murphy, H. M. (1993) · Peptides · doi:10.1016/0196-9781(93)90039-j · Cited by 20
Metadata
- Authors
- VALTIN, H., SAWYER, W. H., & SOKOL, H. W.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1965-10
- Volume
- 77
- Issue
- 4
- Pages
- 701-706
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2138514359
- Cited by
- 213
- References
- 0
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Neurohypophysial Principles in Rats Homozygous and Heterozygous for Hypothalamic Diabetes Insipidus (Brattleboro Strain). https://app.cochat.ai/papers/10.1210/endo-77-4-701
- The paper
- VALTIN, H., SAWYER, W. H., & SOKOL, H. W. (1965). Neurohypophysial Principles in Rats Homozygous and Heterozygous for Hypothalamic Diabetes Insipidus (Brattleboro Strain). Endocrinology. https://doi.org/10.1210/endo-77-4-701
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
