Modulatory effects of vasopressin on glucose and protein metabolism during food-restriction stress
Abstract
Plasma levels of glucose and urea nitrogen were compared in vasopressin-containing (LE) and vasopressin-deficient (DI) rats under ad lib and food-restricted conditions. In the ad lib situation, DI and LE rats had similar levels of glucose and urea nitrogen. Variations in this pattern were observed under food-restricted conditions. The DI animals exhibited lower levels of glucose and higher levels of urea nitrogen than their LE counterparts. During food restriction, the glucose levels of LE animals were not different from that observed under ad lib conditions. A significant decrease, however, was observed in the glucose levels in DI animals during food restriction. Urea nitrogen levels in LE animals decreased during food restriction as compared to the ad lib situation, whereas urea nitrogen levels of DI animals increased during food restriction. These observations indicate that vasopressin has a modulatory role on glucose and protein metabolism during the stress of food restriction.
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A proposed mechanism for high-VP-related glucose intolerance and insulin resistance is that intracellular glucose metabolism is impaired by enhanced gluconeogenesis and/or glycogenolysis.
“One is impaired intracellular glucose metabolism due to increased gluconeogenesis and/or increased glycogenolysis as suggested by acute experiments [31,32], an effect probably related to V1aR activation [29].”
From Vasopressin and hydration play a major role in the development of glucose intolerance and hepatic steatosis in obese rats (2015) · cites this paper as [32]
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- Authors
- Wideman, C. H., & Murphy, H. M.
- Affiliations
- John Carroll University (US)
- Corresponding author
- Wideman, Cyrilla H.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1993-03
- Volume
- 14
- Issue
- 2
- Pages
- 259-261
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2016246317
- Cited by
- 20
- References
- 11
- Citations by year
- 2019: 2 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 2
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Electrolyte and hormonal disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- vasopressin, dietary restriction, glucose metabolism, protein metabolism, urea nitrogen, stress, plasma glucose, plasma urea nitrogen
- MeSH terms
- Animals, Blood Glucose, Blood Urea Nitrogen, Food Deprivation, Gluconeogenesis, Homeostasis, Male, Proteins, Rats, Brattleboro, Stress, Physiological, Vasopressins, Rats
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