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Establishment of Clonal Strains of Rat Pituitary Tumor Cells That Secrete Growth Hormone1,2
Abstract
Three clonal strains of epithelial cells were established from a transplantable rat pituitary tumor. These strains have been serially propagated for 14–25 months. They were subcultured every 2–3 weeks. Cells of the original strain have increased by a factor of more than 1040. The generation times of the 3 lines were similar and ranged between 30 and 40 hr. Cells of all 3 strains synthesize growth hormone and secrete it into the culture medium. Growth hormone synthesized in vitro is indistinguishable from normal rat pituitary growth hormone as measured by micro-complement fixation and radioimmunoassay. The specific activity of growth hormone production was estimated to be 20–40 figμng cell nitrogen/24 hr for the most vigorous strain. There has been no decrease in the rate of cell division nor decline in growth hormone secretion since the cells were established in culture. (Endocrinology82: 342, 1968)
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Citations
Cited by
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Freeman, M. E., Kanyicska, B., Lerant, A., & Nagy, G. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.4.1523 · Cited by 2,457
SACCÀ, L., CITTADINI, A., & FAZIO, S. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-5-555 · Cited by 543
Replacement of serum by hormones permits growth of cells in a defined medium
HAYASHI, I., & SATO, G. H. (1976) · Nature · doi:10.1038/259132a0 · Cited by 414
Self-citation[46] Clonal strains of hormone-producing pituitary cells
Tashjian, A. H. (1979) · Methods in Enzymology · doi:10.1016/s0076-6879(79)58167-1 · Cited by 290
Self-citationCadmium uptake and toxicity via voltage-sensitive calcium channels.
Hinkle, P., Kinsella, P., & Osterhoudt, K. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)49259-9 · Cited by 280
Metadata
- Authors
- TASHJIAN, A. H., YASUMURA, Y., LEVINE, L., SATO, G. H., & PARKER, M. L.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1968-02
- Volume
- 82
- Issue
- 2
- Pages
- 342-352
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2071013566
- Cited by
- 678
- References
- 0
- FWCI
- 13.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- TASHJIAN, A. H., YASUMURA, Y., LEVINE, L., SATO, G. H., & PARKER, M. L. (1968). Establishment of Clonal Strains of Rat Pituitary Tumor Cells That Secrete Growth Hormone1,2. Endocrinology. https://doi.org/10.1210/endo-82-2-342
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