The DOI matches its Crossref record.
The Response of Intestinal Calcium Transport to 25-Hydroxy and 1,25-Dihydroxy Vitamin D in Nephrectomized Rats
Abstract
Nephrectomy but not uremia induced by bilateral ureteral ligation prevents the intestinal calcium transport response to 25- hydroxy vitamin D3. However, it does not prevent the response to 1,25-dihydroxy vitamin D3. These results clearly establish the 1,25 derivative or a further metabolite thereof as the metabolically active form of vitamin D3 in the intestine. This together with the fact that the kidney is the sole site of synthesis of the 1,25 derivative, suggests that 1,25-dihydroxy vitamin D3 may be of great value in preventing and treating bone disease associated with chronic renal failure. (Endocrinology90: 605, 1972)
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Cited by
Eisman, J. A., Hamstra, A. J., Kream, B. E., & DeLuca, H. F. (1976) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(76)90161-2 · Cited by 512
Self-citationBarbour, G. L., Coburn, J. W., Slatopolsky, E., Norman, A. W., & Horst, R. L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198108203050807 · Cited by 425
Holick, M. F., Schnoes, H. K., DeLuca, H. F., Gray, R. W., Boyle, I. T., & Suda, T. (1972) · Biochemistry · doi:10.1021/bi00773a009 · Cited by 329
Self-citationHistory of the discovery of vitamin D and its active metabolites
DeLuca, H. F. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.213 · Cited by 249
Self-citation
Metadata
- Authors
- BOYLE, I. T., MIRAVET, L., GRAY, R. W., HOLICK, M. F., & DELUCA, H. F.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1972-03
- Volume
- 90
- Issue
- 3
- Pages
- 605-608
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2019792296
- Cited by
- 239
- References
- 0
- FWCI
- 39.32
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The Response of Intestinal Calcium Transport to 25-Hydroxy and 1,25-Dihydroxy Vitamin D in Nephrectomized Rats. https://app.cochat.ai/papers/10.1210/endo-90-3-605
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- BOYLE, I. T., MIRAVET, L., GRAY, R. W., HOLICK, M. F., & DELUCA, H. F. (1972). The Response of Intestinal Calcium Transport to 25-Hydroxy and 1,25-Dihydroxy Vitamin D in Nephrectomized Rats. Endocrinology. https://doi.org/10.1210/endo-90-3-605
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