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Hypercalcemia in an Anephric Patient with Sarcoidosis: Evidence for Extrarenal Generation of 1,25-Dihydroxyvitamin D
Abstract
HYPERCALCEMIA can occur in up to 10 per cent of patients with sarcoidosis.1 , 2 During the active phase of the disease, increased absorption of calcium from the intestine leads to hypercalciuria and occasionally hypercalcemia. The increased absorption of calcium is presumed to be secondary to increased sensitivity to vitamin D,3 and it may be decreased or abolished by the development of concomitant renal failure.4 Recent reports have identified elevated circulating levels of 1,25-dihydroxyvitamin D (1,25-[OH]2D) in hypercalcemic patients with sarcoidosis, and it has been suggested that such patients produce increased amounts of 1,25-(OH)2D3 from vitamin D. . . .
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Citations
Cited by
Norman, A. W. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.2.491s · Cited by 1,090
Self-citation1,25‐dihydroxyvitamin D 3 promotes IL‐10 production in human B cells
Heine, G., Niesner, U., Chang, H., Steinmeyer, A., Zügel, U., Zuberbier, T., Radbruch, A., & Worm, M. (2008) · European Journal of Immunology · doi:10.1002/eji.200838216 · Cited by 311
Immunomodulatory role of 1,25‐dihydroxyvitamin D3
Lemire, J. M. (1992) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240490106 · Cited by 299
Seymour, J., & Gagel, R. (1993) · Blood · doi:10.1182/blood.v82.5.1383.1383 · Cited by 291
Metadata
- Authors
- Barbour, G. L., Coburn, J. W., Slatopolsky, E., Norman, A. W., & Horst, R. L.
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 1981-08-20
- Volume
- 305
- Issue
- 8
- Pages
- 440-443
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- OpenAlex
- W2017907756
- Cited by
- 425
- References
- 0
- FWCI
- 20.72
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Hypercalcemia in an Anephric Patient with Sarcoidosis: Evidence for Extrarenal Generation of 1,25-Dihydroxyvitamin D. https://app.cochat.ai/papers/10.1056/nejm198108203050807
- The paper
- Barbour, G. L., Coburn, J. W., Slatopolsky, E., Norman, A. W., & Horst, R. L. (1981). Hypercalcemia in an Anephric Patient with Sarcoidosis: Evidence for Extrarenal Generation of 1,25-Dihydroxyvitamin D. New England Journal of Medicine. https://doi.org/10.1056/nejm198108203050807
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
