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Estrogen and Follicle Stimulating Hormone Interactions on Follicle Growth in Rats
Abstract
The effects of an estrogen (Diethylstilbestrol, DES) and its interaction with follicle stimulating hormone on the ovary were studied in hypophysectomized female rats. DES stimulated increased incorporation of tritiated thymidine into granulosa cell DNA, followed by an increase in the number of granulosa cells. In addition, DES increased ovarian incorporation of tritiated FSH, an effect which was shown to be time and dose related, inhibited by unlabeled FSH, and not seen with tritiated HCG. FSH was less effective than estrogen in stimulating granulosa proliferation but appeared to stimulate antrum formation after appropriate estrogen induced maturation. When the two hormones were given sequentially, there was a marked enhancement in the number of follicles containing antra and a marked increase in ovarian weight. The possible physiologic significance of these observations is discussed. (Endocrinology90: 1492, 1972)
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Cited by
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?
Couse, J. F., & Korach, K. S. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0370 · Cited by 2,045
Physiological factors underlying the formation of ovarian follicular fluid
Gosden, R. G., Hunter, R. H. F., Telfer, E., Torrance, C., & Brown, N. (1988) · Reproduction · doi:10.1530/jrf.0.0820813 · Cited by 169
Concentration of oestrone and oestradiol in follicular fluid and ovarian venous blood of women
BAIRD, D. T., & FRASER, I. S. (1975) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1975.tb01533.x · Cited by 99
Effects of Subchronic Aluminum Exposure on the Reproductive Function in Female Rats
Wang, N., She, Y., Zhu, Y., Zhao, H., Shao, B., Sun, H., Hu, C., & Li, Y. (2012) · Biological Trace Element Research · doi:10.1007/s12011-011-9200-0 · Cited by 41
Metadata
- Authors
- GOLDENBERG, R. L., VAITUKAITIS, J. L., & ROSS, G. T.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1972-06
- Volume
- 90
- Issue
- 6
- Pages
- 1492-1498
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2077018960
- Cited by
- 336
- References
- 0
- FWCI
- 15.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- GOLDENBERG, R. L., VAITUKAITIS, J. L., & ROSS, G. T. (1972). Estrogen and Follicle Stimulating Hormone Interactions on Follicle Growth in Rats. Endocrinology. https://doi.org/10.1210/endo-90-6-1492
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