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Estrogen and Follicle Stimulating Hormone Interactions on Follicle Growth in Rats

GOLDENBERG, R. L., VAITUKAITIS, J. L., ROSS, GRIFF T.·1972·Endocrinology

Abstract

The effects of an estrogen (Diethylstilbestrol, DES) and its interaction with follicle stimulating hormone on the ovary were studied in hypophysectomized female rats. DES stimulated increased incorporation of tritiated thymidine into granulosa cell DNA, followed by an increase in the number of granulosa cells. In addition, DES increased ovarian incorporation of tritiated FSH, an effect which was shown to be time and dose related, inhibited by unlabeled FSH, and not seen with tritiated HCG. FSH was less effective than estrogen in stimulating granulosa proliferation but appeared to stimulate antrum formation after appropriate estrogen induced maturation. When the two hormones were given sequentially, there was a marked enhancement in the number of follicles containing antra and a marked increase in ovarian weight. The possible physiologic significance of these observations is discussed. (Endocrinology90: 1492, 1972)

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Metadata

Authors
GOLDENBERG, R. L., VAITUKAITIS, J. L., & ROSS, G. T.
Venue
Endocrinology
Published
1972-06
Volume
90
Issue
6
Pages
1492-1498
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
OpenAlex
W2077018960
Cited by
336
References
0
FWCI
15.53
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Estrogen and Follicle Stimulating Hormone Interactions on Follicle Growth in Rats. https://app.cochat.ai/papers/10.1210/endo-90-6-1492
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GOLDENBERG, R. L., VAITUKAITIS, J. L., & ROSS, G. T. (1972). Estrogen and Follicle Stimulating Hormone Interactions on Follicle Growth in Rats. Endocrinology. https://doi.org/10.1210/endo-90-6-1492

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