The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Stress-induced intracranial mast cell degranulation: A corticotropin-releasing hormone-mediated effect
Abstract
Stress is known to precipitate or worsen a number of disorders, such as migraines, in which mast cells are suspected of being involved by releasing vasoactive, nociceptive, and proinflammatory mediators. However, no functional association has been demonstrated yet between a migraine trigger and brain mast cell activation. Nontraumatic immobilization (restrain) stress has been shown to stimulate the hypothalamic-pituitary-adrenal axis and to cause redistribution of immune cells. Here, restrain stress caused degranulation in 70% of rat dura mast cells within 30 min, as shown both by light and electron microscopy. These morphologic findings were accompanied by cerebrospinal fluid elevation of rat mast cell protease I, but not II, indicating secretion from connective tissue type mast cells. Mast cell activation due to stress was abolished in animals that had been treated neonatally with capsaicin, indicating that neuropeptides in sensory nerve endings are involved in this response. Complete inhibition was also achieved by pretreating the animals ip with polyclonal antiserum to CRH. Mast cells in the dura were localized close to nerve processes containing substance P, but no CRH-positive fibers were identified even though these were found close to mast cells in the median eminence. This is the first time that stress is shown to activate intracranial mast cells; apparently through the sequential action of CRH and sensory neuropeptides. These findings may have implications for the pathophysiology and possible therapy of neuroinflammatory disorders such as migraines, which are induced or exacerbated by stress.
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“Stress, considered a major factor exacerbating migraine pain, has been shown in preclinical rodent studies to cause the degranulation of intracranial mast cells, an effect mediated by neuropeptides [43].”
From The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders (2023) · cites this paper as [43]
Citations
Cites
The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation
Chrousos, G. P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199505183322008 · Cited by 2,579
Self-citationNew Concepts about the Mast Cell
Flier, J. S., Underhill, L. H., & Galli, S. J. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301283280408 · Cited by 981
Dimitriadou, V., Lambracht-Hall, M., Reichler, J., & Theoharides, T. C. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90234-u · Cited by 110
Self-citationMast cells and the nerves—potential interactions in the context of chronic disease
Marshall, J. S., & Waserman, S. (1995) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1995.tb01013.x · Cited by 74
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Sorted by citations
Stress and disorders of the stress system
Chrousos, G. P. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.106 · Cited by 3,215
Self-citationStress Hormones, Proinflammatory and Antiinflammatory Cytokines, and Autoimmunity
ELENKOV, I. J., & CHROUSOS, G. P. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04229.x · Cited by 983
Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776
The Role of Cortisol in Chronic Stress, Neurodegenerative Diseases, and Psychological Disorders
Knezevic, E., Nenic, K., Milanovic, V., & Knezevic, N. N. (2023) · Cells · doi:10.3390/cells12232726 · Cited by 564
“Stress, considered a major factor exacerbating migraine pain, has been shown in preclinical rodent studies to cause the degranulation of intracranial mast cells, an effect mediated by neuropeptides [43].”
BackgroundStress, the Stress System and the Role of Glucocorticoids
Nicolaides, N. C., Kyratzi, E., Lamprokostopoulou, A., Chrousos, G. P., & Charmandari, E. (2015) · Neuroimmunomodulation · doi:10.1159/000362736 · Cited by 477
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Metadata
- Authors
- Theoharides, T. C., Spanos, C., Pang, X., Alferes, L., Ligris, K., Letourneau, R., Rozniecki, J. J., Webster, E., & Chrousos, G. P.
- Affiliations
- Tufts University (US)
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1995-12
- Volume
- 136
- Issue
- 12
- Pages
- 5745-5750
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2033052846
- Semantic Scholar
- 45fd10b0c80e30cba8eb268053ff8eee1df8af64
- Cited by
- 214
- References
- 4
- Citations by year
- 2026: 2 · 2024: 9 · 2023: 5 · 2022: 7 · 2021: 11 · 2020: 3 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 7 · 2015: 6 · 2014: 8 · 2013: 7 · 2012: 4
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Clinical Neurology › Migraine and Headache Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- mast cell degranulation, dura mater, corticotropin-releasing factor, restraint stress, hypothalamic-pituitary-adrenal axis, capsaicin, sensory neuropeptides, substance P, migraine, neuroinflammation, connective tissue mast cells
- MeSH terms
- Animals, Brain, Corticotropin-Releasing Hormone, Male, Mast Cells, Migraine Disorders, Restraint, Physical, Stress, Physiological, Cell Degranulation, Rats, Sprague-Dawley, Rats
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