Photoperiod effects on neurohypophyseal and tuberoinfundibular dopamine metabolism in the male hamster
Abstract
Exposure of golden hamsters to a short photoperiod (< 12.5 h light/day) leads to suppression of gonadal function secondary to reduced gonadotropin and PRL secretion. PRL secretion is decreased despite a reduction of tuberoinfundibular dopaminergic activity. In the present study, the ability of photoperiod to affect tuberohypophyseal dopamine (DA) turnover was evaluated in long day (LD; 16 h of light, 8 h of darkness) and short day (SD; 8 h of light, 16 h of darkness) male hamsters. Exposure to SD led to decreases in testicular weight within 10 weeks and decreases in plasma PRL levels within 1 week. DA turnover in the neurointermediate lobe of the pituitary, as estimated by measuring the depletion of DA 60 min after tyrosine hydroxylase inhibition with alpha-methyl-p-tyrosine (250 mg/kg), was significantly elevated 1 and 4 weeks after transfer to SD, but returned by 10 weeks to the levels seen in LD animals. After 14 days of SD exposure an enhanced lactotroph sensitivity to DA was demonstrated and may also have contributed to suppression of PRL levels. Similarly to the findings of previous studies, DA turnover in the median eminence was depressed in animals housed in SD. The DA content of the anterior pituitary was not significantly affected by photoperiod. The data from this study suggest that decreases in PRL secretion associated with the transfer of hamsters from LD to SD conditions are at least in part caused by an increase in DA turnover by neurohypophyseal neurons. However, the involvement of other PRL-inhibiting or -stimulating factors in mediating the effects of photoperiod on PRL secretion cannot be ruled out.
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Animal studies suggest that short days increase dopamine turnover in the pituitary and suppress tyrosine hydroxylase expression in the prefrontal cortex.
“In line with this hypothesis, animal studies suggest that short days increase dopamine turnover in the pituitary (Steger et al., 1995) and suppress tyrosine hydroxylase expression in the prefrontal cortex (Sorg et al., 2011).”
From Behavioral and cognitive effects of tyrosine intake in healthy human adults (2015) · cites this paper as Steger et al., 1995
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Biology of Mammalian Photoperiodism and the Critical Role of the Pineal Gland and Melatonin
Malpaux, B., Migaud, M., Tricoire-Leignel, H., & Chemineau, P. (2001) · Journal of Biological Rhythms · doi:10.1177/074873001129002051 · Cited by 371 · see citing works
“Suppression of LH and follicle-stimulating hormone (FSH) release in this species is presumably related to reduced noradrenaline activity, whereas reduced dopamine turnover may represent a consequence of suppression of prolactin levels by short days (Steger et al., 1995).”
BackgroundInfluentialMelatonin and the seasonal control of reproduction
Malpaux, B., Thiéry, J.-C., & Chemineau, P. (1999) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19990308 · Cited by 161 · see citing works
“In male Syrian hamsters, exposure to inhibitory short days, presumably through melatonin secretion, reduces dopamine and noradrenaline turnover in the median eminence [60, 61].”
Seasonal Regulation of Reproduction in Mammals
Malpaux, B. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50046-4 · Cited by 102 · see citing works
Behavioral and cognitive effects of tyrosine intake in healthy human adults
Hase, A., Jung, S. E., & aan het Rot, M. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.008 · Cited by 91 · see citing works
“In linewith this hypothesis, animal studies suggest that short days increase dopamine turnover in the pituitary (Steger et al., 1995) and suppress tyrosine hydroxylase expression in the prefrontal cortex (Sorg et al., 2011).”
BackgroundViguié, C., Thibault, J., Thiéry, J.-C., et al. (1997) · Endocrinology · doi:10.1210/endo.138.1.4865 · Cited by 34 · see citing works
The Effect of Melatonin on Suckling-Induced Oxytocin and Prolactin Release in the Rat
Juszczak, M., & Stempniak, B. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00117-2 · Cited by 27 · see citing works
Self-citationBöckers, T. M., Bockmann, J., Salem, A., et al. (1997) · Endocrinology · doi:10.1210/endo.138.10.5423 · Cited by 24 · see citing works
Alexiuk, N. A. M., & Vriend, J. P. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-006-0582-7 · Cited by 23 · see citing works
“Melatonin, a serotonin derivative, has been demonstrated to modify the activity of the rate-limiting enzyme of catecholamine synthesis, tyrosine hydroxylase (TH), as well as to decrease DA concentrations in the median eminence=arcuate region of the medial basal hypothalamus (MBH) (Alexiuk et al., 1996) and in the tube…”
BackgroundChapter VIII Functional neuroanatomy of hypothalamic dopaminergic neuroendocrine systems
Lookingland, K. J., & Moore, K. E. (2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80012-0 · Cited by 17 · see citing works
Cónsole, G. M., Jurado, S., Petruccelli, M. Á., et al. (2002) · Neuroendocrinology · doi:10.1159/000057341 · Cited by 15 · see citing works
Prolactin Mediates Long-Term, Seasonal Rheostatic Regulation of Body Mass in Female Mammals
Marshall, C. J., Blake, A., Stewart, C., Liddle, T. A., Denizli, I., Cuthill, F., Evans, N. P., & Stevenson, T. J. (2024) · Endocrinology · doi:10.1210/endocr/bqae020 · Cited by 13 · see citing works
Juszczak, M., Steger, R. W., Debéljuk, L., et al. (1996) · Endocrine · doi:10.1007/bf02738688 · Cited by 6 · see citing works
Self-citationPiekarski, D. J., Jarjisian, S. G., & Zucker, I. (2012) · Chronobiology International · doi:10.3109/07420528.2012.699125 · Cited by 2 · see citing works
“Altered neurotransmitter dynamics in short days (Steger et al., 1995) may render hypothalamic and limbic tissues less responsive to dopaminergic modulation of mating behavior.”
BackgroundPiekarski, D. J. (2012) · eScholarship (California Digital Library)
- Authors
- Steger, R. W., Juszczak, M., Fadden, C., & Bartke, A.
- Affiliations
- Southern Illinois University Carbondale (US)
- ORCID
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1995-07
- Volume
- 136
- Issue
- 7
- Pages
- 3000-3006
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W1974725979
- Cited by
- 15
- References
- 0
- Citations by year
- 2024: 1 · 2015: 1 · 2012: 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hd020033-12)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-20033)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- photoperiod, prolactin secretion, median eminence, neurointermediate lobe, testicular weight, gonadal suppression, alpha-methyl-p-tyrosine, tyrosine hydroxylase inhibition, golden hamster, short-day photoperiod
- MeSH terms
- Animals, Dopamine, Cricetinae, Hypothalamus, Male, Mesocricetus, Pituitary Gland, Posterior, Prolactin, Photoperiod
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