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Cited by 88Hormonal Regulation and HypertensionAdrenal Hormones and DisordersEstrogen and related hormone effects

Localization of 11beta-hydroxysteroid dehydrogenase type 2 in rat tissues: in situ studies.

Roland, B L, Funder, J W·1996·Endocrinology
DOI 10.1210/endo.137.3.8603583
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Abstract

In the rat, the enzyme 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2) converts the glucocorticoid corticosterone into receptor-inactive 11-dehydrocorticosterone, thereby allowing preferential access of aldosterone to mineralocorticoid receptors (MR). The present study examines the distribution of this enzyme by in situ hybridization, using a homologous complementary RNA probe for 11betaHSD2. 11betaHSD2 messenger RNA was detected in classic epithelial aldosterone target tissues (kidney, salivary glands, and colon), the female reproductive system (ovary, oviduct, uterus, and placenta), and the adrenals; levels in heart, testis, and liver were below the limits of detection. We interpret the finding of 11betaHSD2 expression in both classical MR-containing aldosterone target tissues and a variety of other tissue as evidence that in the rat, the enzyme may play physiological roles in addition to that of excluding glucocorticoids from epithelial MR.

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Authors
Roland, B. L., & Funder, J. W.
ORCID
Funder, J W
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1996-03
Volume
137
Issue
3
Pages
1123-1128
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.137.3.8603583
OpenAlex
W2009703358
Cited by
88
References
0
Citations by year
2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
6.45
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council
  • National Health and Medical Research Council
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
11β-hydroxysteroid dehydrogenase type 2, enzyme localization, tissue distribution, mineralocorticoid receptor, aldosterone, corticosterone, 11-dehydrocorticosterone, kidney, salivary glands, colon, female reproductive system, adrenal gland, messenger RNA expression
MeSH terms
Animals, Female, Hydroxysteroid Dehydrogenases, Male, Organ Specificity, RNA, Messenger, Rats, Sprague-Dawley, In Situ Hybridization, 11-beta-Hydroxysteroid Dehydrogenases, Rats

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