Cited by 769Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

Cheung, Clement C., Clifton, Donald K., Steiner, Robert A.·1997·Endocrinology

DOI 10.1210/endo.138.10.5570

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Abstract

Leptin is a protein product of the obese (ob) gene, which is secreted by adipocytes and functions as a satiety factor to regulate food intake. The expression of the leptin receptor in several hypothalamic nuclei suggests that multiple neuronal subtypes are targets for leptin's action. Products of the proopiomelanocortin (POMC) gene are known to affect feeding behavior, and POMC neurons share a similar distribution with leptin receptor mRNA in the arcuate nucleus. We used double label in situ hybridization and computerized image analysis to test the hypothesis that POMC neurons coexpress the leptin receptor. Quantitative analysis confirmed that POMC neurons in the hypothalamus express leptin receptor mRNA. Based on this observation, we infer that POMC neurons and the products of the POMC gene may be part of the signaling pathway mediating leptin's action on feeding and perhaps other physiological functions.

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Crossref · 10.1210/endo.138.10.5570

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“Perhaps the most promising approach to explain the interactions of alcohol consumption and leptin focuses on the role of pro-opiomelanocortin (POMC) mRNA expression (Cheung et al., 1997; Fan et al., 1997; Schwartz et al., 1997).”
Background
Molekulare Grundlagen der Adipositas
Hebebrand, J., Hinney, A., & Oeffner, F. (2001) · Springer eBooks · doi:10.1007/978-3-642-56858-9_12 · Cited by 6
Rare variants in the melanocortin 4 receptor gene (MC4R) are associated with abdominal fat and insulin resistance in youth with obesity
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“…and inducing the release of alpha-melanocyte stimulating hormone ( α -MSH), a post-translational product of pro-opiomelanocortin (POMC) [8]. α -MSH binds the melanocortin 4 receptor (MC4R) in the paraventricular nucleus of the hypothalamus and triggers a signaling cascade that leads to…”
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AgRP Neuron-Specific Ablation Represses Appetite, Energy Intake, and Somatic Growth in Larval Zebrafish
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Regulation of feeding and metabolism by fat mass and obesity-associated protein in zebrafish
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“Accordingly, leptin has the role of a signaling molecule of the nutritional and fat mass status to the brain (Schwartz et al. 2000; Cheung et al. 1997).”
Background

Authors: Cheung, C. C., Clifton, D. K., & Steiner, R. A.
Affiliations: University of Washington (US)
Corresponding author: Steiner, Robert A.
ORCID: Steiner, Robert A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1997-10
Volume: 138
Issue: 10
Pages: 4489-4492
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.138.10.5570
OpenAlex: W2129221666
Cited by: 769
References: 0
Citations by year: 2026: 2 · 2025: 9 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 14 · 2020: 12 · 2019: 14 · 2018: 14 · 2017: 18 · 2016: 15 · 2015: 24 · 2014: 20 · 2013: 30 · 2012: 34
FWCI: 15.45
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32gm007108-40)
National Institute of General Medical Sciences (5 T32-GM07108)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 27142, R01HD027142)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, proopiomelanocortin, POMC neurons, leptin receptor, hypothalamus, arcuate nucleus, feeding behavior, satiety, food intake regulation, obese gene
MeSH terms: Animals, Carrier Proteins, Eating, Female, Gene Expression Regulation, Hypothalamus, Image Processing, Computer-Assisted, Neurons, Pro-Opiomelanocortin, Proteins, Receptors, Cell Surface, RNA, Messenger, Signal Transduction, Rats, Sprague-Dawley, In Situ Hybridization, Leptin, Rats, Receptors, Leptin

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Proopiomelanocortin Neurons Are Direct Targets for Leptin in the Hypothalamus

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