Central Control of Glucose Homeostasis
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The Review of Diabetic Studies,2006,3,2,54-60.DOI:10.1900/RDS.2006.3.54Published:August 2006Type:EditorialAuthors:Antonella Puglianiello, and Stefano Cianfarani Author(s) affiliations:Antonella Puglianiello and Stefano Cianfarani "Rina Balducci" Center of Pediatric Endocrinology, Department of Public Health and Cell Biology, Tor Vergata University, 00133-Rome, Italy. Abstract:Type 2 diabetes is a complex disease mainly characterized by impaired insulin action and insulin secretion [1, 2]. A major breakthrough in the understanding of mechanisms leading to type 2 diabetes has recently come from studies on the central nervous system (CNS) dependent regulation of glucose and fat metabolism. The concept that the CNS has an essential role in glucose homeostasis and insulin action is not new. In 1849, Claude Bernard reported that pricking the floor of the fourth ventricle in rabbits produced hyperglycemia [3]. The past decade has greatly increased knowledge about the ability of the CNS to regulate food intake, body weight and glucose homeostasis. It is now clear that the CNS, and in particular the hypothalamus, plays a pivotal role in regulating glucose homeostasis independently of its effects on body weight. Therefore, some of the molecular defects underlying type 2 diabetes may reside in the CNS, supporting the concept that type 2 diabetes is, at least in part, a hypothalamic disorder. Keywords:NilView:PDF (288.88 KB)
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An increase in insulin signal in the hypothalamus elicits responses that reduce hepatic glucose production.
“For example, an increase in insulin signal in the hypothalamus elicits responses that reduce hepatic glucose production [31].”
From A mathematical model of brain glucose homeostasis (2009) · cites this paper as [31]
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A mathematical model of brain glucose homeostasis
Gaohua, L., & Kimura, H. (2009) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-6-26 · Cited by 29 · see citing works
- Authors
- Puglianiello, A., & Cianfarani, S.
- Affiliations
- University of Rome Tor Vergata (IT)
- ORCID
- Cianfarani, Stefano
- Venue
- The Review of Diabetic Studies
- Publisher
- Raiya Academic International LLC
- Published
- 2006
- Volume
- 3
- Issue
- 2
- Pages
- 54-54
- ISSN
- 1613-6071 (ISSN-L)
- 1613-0575
- PMC
- PMC1783580
- OpenAlex
- W198654174
- Cited by
- 14
- References
- 70
- Citations by year
- 2025: 1 · 2022: 1 · 2020: 2 · 2019: 2 · 2017: 1 · 2013: 1 · 2012: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- The Review of Diabetic Studies (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- glucose homeostasis, type 2 diabetes, central nervous system, hypothalamus, insulin action, insulin secretion, food intake regulation, body weight regulation, fat metabolism
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