Cited by 437Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

Thornton, Janice E., Cheung, Clement C., Clifton, Donald K., Steiner, Robert A.·1997·Endocrinology

DOI 10.1210/endo.138.11.5651

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Abstract

The hormone leptin acts on the brain to regulate feeding, metabolism, and reproduction; however, its cellular targets and molecular mechanisms of action remain to be fully elucidated. The melanocortins, which are derived from the precursor proopiomelanocortin (POMC), are also implicated in the physiological regulation of body weight. POMC-containing neurons express the leptin receptor, and thus it is conceivable that the POMC gene itself may be part of the signaling pathway involved in leptin's action on the brain. Using in situ hybridization and computerized image analysis, we tested the hypothesis that the POMC gene is a target for regulation by leptin by comparing cellular levels of POMC mRNA in the hypothalamus among groups of leptin-deficient (ob/ob) mice, leptin-treated ob/ob mice, and wild-type controls. POMC mRNA levels were significantly reduced throughout the arcuate nucleus in vehicle-treated ob/ob mice relative to wild-type controls, whereas POMC mRNA levels in leptin-treated ob/ob mice were indistinguishable from wild-type controls. These observations suggest that one or more products of POMC serve as an integrative link between leptin and the central mechanisms governing body weight regulation and reproduction.

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Authors: Thornton, J. E., Cheung, C. C., Clifton, D. K., & Steiner, R. A.
Affiliations: University of Washington (US)
Corresponding author: Clifton, Donald K.
ORCID: Steiner, Robert A.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1997-11-01
Volume: 138
Issue: 11
Pages: 5063-5066
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.138.11.5651
OpenAlex: W2064342369
Cited by: 437
References: 0
Citations by year: 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 6 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 7 · 2015: 12 · 2014: 9 · 2013: 12 · 2012: 9
FWCI: 12.23
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
ResearchWorks at the University of Washington (University of Washington) (submittedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 27142, P50HD012629, R01HD027142, P50-HD-12629)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, proopiomelanocortin, POMC mRNA, hypothalamus, arcuate nucleus, ob/ob mice, leptin receptor, melanocortin peptides, body weight regulation, reproduction, gene expression regulation
MeSH terms: Animals, Cell Count, Eating, Hypothalamus, Male, Mice, Mutant Strains, Neurons, Obesity, Pro-Opiomelanocortin, Proteins, RNA, Messenger, Leptin, Mice

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Regulation of Hypothalamic Proopiomelanocortin mRNA by Leptin in ob/ob Mice

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