Cited by 580Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

Rossi, M., Kim, M. S., Morgan, D. G. A., Small, C. J., Edwards, C. M. B., Sunter, D., Abusnana, S., Goldstone, A. P., Russell, S. H., Stanley, S. A., Smith, D. M., Yagaloff, K., Ghatei, M. A., Bloom, S. R.·1998·Endocrinology

DOI 10.1210/endo.139.10.6332

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Abstract

Agouti-related protein (Agrp) is present in rat and human hypothalamus and is structurally related to agouti protein. Overexpression of either of these proteins results in obesity. However the effect of exogenous Agrp and its in vivo interaction with alpha-melanocyte stimulating hormone (alphaMSH), the likely endogenous melanocortin 3 and 4 receptor (MC3-R and MC4-R) agonist, have not been demonstrated. We report that 1 nmol of Agrp(83-132), a C-terminal fragment of Agrp, when administered intracerebroventricularly (ICV) into rats, increased food intake over a 24-h period (23.0+/-1.4 g saline vs 32.9+/-2.3 g Agrp, p<0.05). The hyperphagia was similar to that seen when 1 nmol of the synthetic MC3-R and MC4-R antagonist SHU9119 was given i.c.v. (19.6+/-1.8 g saline vs 32.5+/-1.7 g SHU9119, p<0.001). Both Agrp(83-132) and SHU9119 blocked the reduction in 1-h food intake of i.c.v. alphaMSH at the beginning of the dark phase. This effect occurred independently of whether the antagonists were administered simultaneously, or nine hours prior, to the alphaMSH. We have also shown Agrp(83-132) is an antagonist at the MC3-R and MC4-R, with similar inhibition of cAMP activation to that previously reported for the full length peptide. In conclusion, Agrp(83-132) administered i.c.v. increases feeding with long lasting effects and is able to inhibit the action of alphaMSH. This interaction may be mediated by the MC3-R and/or MC4-R.

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Background
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Background
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Background
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Background
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Wirth, M. M., & Giraudo, S. Q. (2000) · Peptides · doi:10.1016/s0196-9781(00)00280-1 · Cited by 77
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Lawrence, C. B., Liu, Y.-L., Stock, M. J., & Luckman, S. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00402.2003 · Cited by 76
“Since higher doses of SHU9119 can initiate food intake at later time points (9, 40), we confirmed also that it did not reverse the effect of PrRP on cumulative food intake over an 8 h period.”
Background
Gliotransmission and Brain Glucose Sensing
Lanfray, D., Arthaud, S., Ouellet, J., Compère, V., do Rego, J. L., Leprince, J., Lefranc, B., Castel, H., Bouchard, C., Monge-Roffarello, B., et al. (2012) · Diabetes · doi:10.2337/db11-0785 · Cited by 81
“See http://creativecommons.org/licenses/by -nc-nd/3.0/ for details. diabetes.diabetesjournals.org DIABETES, VOL. 62, MARCH 2013 801 Moreover, the intracerebroventricular injection of ODN increases POMC mRNA levels and decreases NPY mRNA levels in the arcuate nucleus (25).”
BackgroundInfluential
Modification of feeding circuits in the evolution of social behavior
Fischer, E. K., & O’Connell, L. A. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.143859 · Cited by 74
“Peptide hormones important for feeding behavior Vertebrate peptide Invertebrate homolog Effect on feeding behavior Reference Agouti-related protein (AgRP) n/a Stimulant Rossi et al., 1998 α-Melanocyte stimulating hormone (α-MSH) n/a Suppressant Murphy et al., 1998 Brain-derived neurotrophic factor (BDNF) Neurotrophins…”
Background
Obesity as a Neuroendocrine Disease: Lessons to Be Learned from Proopiomelanocortin and Melanocortin Receptor Mutations in Mice and Men
Wardlaw, S. L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.4.7388 · Cited by 75
The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus
Perello, M., Stuart, R. C., & Nillni, E. A. (2006) · Endocrinology · doi:10.1210/en.2005-1533 · Cited by 74
Neurophysiology of hunger and satiety
Smith, P., & Ferguson, A. V. (2008) · Developmental Disabilities Research Reviews · doi:10.1002/ddrr.13 · Cited by 82
Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP
Zheng, H., Corkern, M. M., Crousillac, S. M., Patterson, L. M., Phifer, C. B., & Berthoud, H. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00019.2002 · Cited by 74
“In contrast, intracerebroventricular injection of AgRP induces robust food intake (54) that lasts for several days (29).”
Background
Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8
Blevins, J. E., Morton, G. J., Williams, D. L., Caldwell, D. W., Bastian, L. S., Wisse, B. E., Schwartz, M. W., & Baskin, D. G. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90544.2008 · Cited by 73
“Blockade of central melanocortin signaling by intracerebroventricular administration of either the endogenous melanocortin receptor antagonist agouti-related peptide (AGRP) or the synthetic MC3/MC4 antagonist SHU9119 produces hyperphagia and obesity (19, 35, 38) and attenuates the anorexic response to leptin (14, 43).”
Regulation of Energy Balance in Birds by the Neuroendocrine Hypothalamus
Boswell, T. (2005) · The Journal of Poultry Science · doi:10.2141/jpsa.42.161 · Cited by 74
THE NEUROENDOCRINOLOGY OF OBESITY
Lustig, R. H. (2001) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70211-5 · Cited by 73
Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release
Goazigo, A. R.-L., Bodineau, L., Mota, N. D., Jeandel, L., Chartrel, N., Knauf, C., Raad, C., Valet, P., & Llorens‐Cortés, C. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00090.2011 · Cited by 78
PRL-Releasing Peptide Inhibits Food Intake in Male Rats via the Dorsomedial Hypothalamic Nucleus and not the Paraventricular Hypothalamic Nucleus
Seal, L., Small, C. J., Dhillo, W. S., Stanley, S. A., Abbott, C. R., Ghatei, M. A., & Bloom, S. R. (2001) · Endocrinology · doi:10.1210/endo.142.10.8419 · Cited by 73
“Intracerebroventricular injection of MSH inhibits feeding (19), as does intranuclear injection of the long-acting MSH analog [Nle4,d-Phe7]MSH (NDP-MSH), whereas injection of AgRP-(83–132) increases feeding ( 20 ).”
BackgroundSelf-citation
Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin‐4 receptor knockout mouse
Haskell‐Luevano, C., Schaub, J. W., Andreasen, A., Haskell, K. R., Moore, M. C., Koerper, L. M., Rouzaud, F., Baker, H. V., Millard, W. J., Walter, G., et al. (2009) · The FASEB Journal · doi:10.1096/fj.08-109686 · Cited by 72
Constitutive Activity in Melanocortin-4 Receptor
Tao, Y. (2014) · Advances in pharmacology · doi:10.1016/b978-0-12-417197-8.00005-5 · Cited by 71
The Agouti-related protein and its role in energy homeostasis
Stütz, A. M., Morrison, C. D., & Argyropoulos, G. A. (2005) · Peptides · doi:10.1016/j.peptides.2004.12.024 · Cited by 75
Down-regulation of orexin gene expression by severe obesity in the rats: studies in Zucker fatty and Zucker diabetic fatty rats and effects of rosiglitazone
Cai, X., Lister, C. A., Buckingham, R. E., Pickavance, L. C., Wilding, J. P. H., Arch, J. R. S., Wilson, S., & Williams, G. H. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00041-3 · Cited by 72
Nutrition and the circadian timing system
Stenvers, D. J., Jonkers‐Schuitema, C. F., Fliers, E., Bisschop, P. H. L. T., & Kalsbeek, A. (2012) · Progress in brain research · doi:10.1016/b978-0-444-59427-3.00020-4 · Cited by 70
Mode of leptin action in chicken hypothalamus
Dridi, S., Swennen, Q., Decuypere, E. M. P., & Buyse, J. G. (2005) · Brain Research · doi:10.1016/j.brainres.2005.04.034 · Cited by 71
KO's and organisation of peptidergic feeding behavior mechanisms
Beck, B. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00003-3 · Cited by 73
The Hypothalamic Melanocortin System Stimulates the Hypothalamo-Pituitary-Adrenal Axis in vitro and in vivo in Male Rats
Dhillo, W. S., Small, C. J., Seal, L., Kim, M.-S., Stanley, S. A., Murphy, K. G., Ghatei, M. A., & Bloom, S. R. (2002) · Neuroendocrinology · doi:10.1159/000054712 · Cited by 71
“ICV administration of Agrp(83–132) produces a long-lasting increase in food intake and is able to reverse the anorectic action of α-MSH [”
BackgroundSelf-citation
Neuropeptides in Hypothalamic Neuronal Disorders
Swaab, D. F. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)40003-5 · Cited by 69
Melanocortin-4 Receptor (MC4R) Agonists for the Treatment of Obesity
Nargund, R. P., Strack, A. M., & Fong, T. M. (2006) · Journal of Medicinal Chemistry · doi:10.1021/jm058241a · Cited by 70
Tonic inhibition of food intake during inactive phase is reversed by the injection of the melanocortin receptor antagonist into the paraventricular nucleus of the hypothalamus and central amygdala of the rat
Kask, A., & Schiöth, H. B. (2000) · Brain Research · doi:10.1016/s0006-8993(00)03034-1 · Cited by 70
Agouti-Related Protein-Like Immunoreactivity: Characterization of Release from Hypothalamic Tissue and Presence in Serum
Li, J.-Y., Finniss, S., Yang, Y.-K., Zeng, Q., Qu, S.-Y., Barsh, G. S., Dickinson, C. J., & Gantz, I. (2000) · Endocrinology · doi:10.1210/endo.141.6.7462 · Cited by 74
Intraventricular melanin-concentrating hormone stimulates water intake independent of food intake
Clegg, D. J., Air, E. L., Benoit, S. C., Sakai, R. R., Seeley, R. J., & Woods, S. C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00399.2002 · Cited by 69
Targeting Intermediary Metabolism in the Hypothalamus as a Mechanism to Regulate Appetite
Lopaschuk, G. D., Ussher, J. R., & Jaswal, J. S. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002428 · Cited by 71
Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity
Gan, H., Cerbone, M., & Dattani, M. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad033 · Cited by 75
Central infusion of the melanocortin receptor antagonist agouti-related peptide (AgRP(83-132)) prevents cachexia-related symptoms induced by radiation and colon-26 tumors in mice
Joppa, M. A., Gogas, K. R., Foster, A. C., & Markison, S. (2007) · Peptides · doi:10.1016/j.peptides.2006.11.021 · Cited by 69
An overview of mongenic and syndromic obesities in humans
Chung, W. K. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.23372 · Cited by 76
“The autosomal dominant agouti promoter mutation A results in ubiquitous ectopic overexpression of agouti signaling protein (ASP) throughout the body, producing the characteristic yellow coat color when it antagonizes the binding of alpha melanocortin stimulating hormone (a MSH) at melancortin 1 receptors (MC1R) in the…”
Background
Centrally administered MTII affects feeding, drinking, temperature, and activity in the Sprague-Dawley rat
Murphy, B. A., Nunes, C. N., Ronan, J. J., Hanaway, M., Fairhurst, A., & Mellin, T. N. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.1.273 · Cited by 68
Prokineticin 2 Is a Hypothalamic Neuropeptide That Potently Inhibits Food Intake
Gardiner, J., Bataveljic, A., Patel, N. A., Bewick, G. A., Roy, D., Campbell, D., Greenwood, H. C., Murphy, K. G., Hameed, S., Jethwa, P. H., et al. (2009) · Diabetes · doi:10.2337/db09-1198 · Cited by 72
“The doses of -MSH and AgRP were chosen based on previous studies (35).”
Self-citation
Novel insight in distribution of nesfatin-1 and phospho-mTOR in the arcuate nucleus of the hypothalamus of rats
Inhoff, T., Stengel, A., Peter, L., Goebel, M., Taché, Y., Bannert, N., Wiedenmann, B., Klapp, B. F., Mönnikes, H., & Kobelt, P. (2009) · Peptides · doi:10.1016/j.peptides.2009.11.024 · Cited by 69
Melanocortin activity in the amygdala controls appetite for dietary fat
Boghossian, S., Park, M., & York, D. A. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00591.2009 · Cited by 66
Effects of Neuropeptides and Leptin on Nutrient Partitioning: Dysregulations in Obesity
Jeanrenaud, B., & Rohner‐Jeanrenaud, F. (2001) · Annual Review of Medicine · doi:10.1146/annurev.med.52.1.339 · Cited by 66

Authors: Rossi, M., Kim, M. S., Morgan, D. G. A., Small, C. J., Edwards, C. M. B., Sunter, D., Abusnana, S., Goldstone, A. P., Russell, S. H., Stanley, S. A., Smith, D. M., Yagaloff, K., Ghatei, M. A., & Bloom, S. R.
Affiliations: Hammersmith Hospital (GB)
ORCID: Abusnana, S.
Goldstone, A. P.
Stanley, S. A.
Smith, D. M.
Bloom, S. R.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1998-10
Volume: 139
Issue: 10
Pages: 4428-4431
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.139.10.6332
OpenAlex: W2171010063
Cited by: 576
References: 0
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 15 · 2014: 16 · 2013: 22 · 2012: 29
FWCI: 11.74
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: agouti-related protein, C-terminal fragment, alpha-melanocyte-stimulating hormone, melanocortin 3 receptor, melanocortin-4 receptor, dietary intake, hyperphagia, SHU9119, obesity, hypothalamus, cAMP signaling, intracerebroventricular administration
MeSH terms: alpha-MSH, Animals, Dose-Response Relationship, Drug, Eating, Injections, Intraventricular, Male, Peptide Fragments, Proteins, Rats, Wistar, Receptors, Corticotropin, Intercellular Signaling Peptides and Proteins, Receptor, Melanocortin, Type 3, Rats, Agouti Signaling Protein, Agouti-Related Protein

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A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

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