Cited by 580Regulation of Appetite and ObesityNeuropeptides and Animal PhysiologyHypothalamic control of reproductive hormones

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A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

Rossi, M., Kim, M. S., Morgan, D. G. A., Small, C. J., Edwards, C. M. B., Sunter, D., Abusnana, S., Goldstone, A. P., Russell, S. H., Stanley, S. A., Smith, D. M., Yagaloff, K., Ghatei, M. A., Bloom, S. R.·1998·Endocrinology

DOI 10.1210/endo.139.10.6332

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Abstract

Agouti-related protein (Agrp) is present in rat and human hypothalamus and is structurally related to agouti protein. Overexpression of either of these proteins results in obesity. However the effect of exogenous Agrp and its in vivo interaction with alpha-melanocyte stimulating hormone (alphaMSH), the likely endogenous melanocortin 3 and 4 receptor (MC3-R and MC4-R) agonist, have not been demonstrated. We report that 1 nmol of Agrp(83-132), a C-terminal fragment of Agrp, when administered intracerebroventricularly (ICV) into rats, increased food intake over a 24-h period (23.0+/-1.4 g saline vs 32.9+/-2.3 g Agrp, p<0.05). The hyperphagia was similar to that seen when 1 nmol of the synthetic MC3-R and MC4-R antagonist SHU9119 was given i.c.v. (19.6+/-1.8 g saline vs 32.5+/-1.7 g SHU9119, p<0.001). Both Agrp(83-132) and SHU9119 blocked the reduction in 1-h food intake of i.c.v. alphaMSH at the beginning of the dark phase. This effect occurred independently of whether the antagonists were administered simultaneously, or nine hours prior, to the alphaMSH. We have also shown Agrp(83-132) is an antagonist at the MC3-R and MC4-R, with similar inhibition of cAMP activation to that previously reported for the full length peptide. In conclusion, Agrp(83-132) administered i.c.v. increases feeding with long lasting effects and is able to inhibit the action of alphaMSH. This interaction may be mediated by the MC3-R and/or MC4-R.

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English, P., & Wilding, J. P. H. (2002) · Current Paediatrics · doi:10.1054/cupe.2001.0264 · Cited by 3
Hormonal regulation of the mouse adrenal melanocortinergic system
Soltani, Y., Doghman, M., Gout, J., Rebuffet, V., Vigier, M., Bekkouche, F. H., Naville, D., & Bégeot, M. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03345678 · Cited by 3
[Alterations in hypothalamus-adipose tissue axis in relation with the risk of coronary atherosclerosis].
Coniglio, R. I., Dahinten, E., Boeri, M. P., Lebrun, F., & Monsalve, A. M. (2004) · PubMed · Cited by 3
Current trends in targeting the hormonal regulation of appetite and energy balance to treat obesity
Valentino, M. A., Colón‐González, F., Lin, J. E., & Waldman, S. A. (2010) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.33 · Cited by 3
Hormonal mediation of energy homeostasis in obesity, diabetes and related disorders
Woods, S. C., & Seeley, R. J. (2005) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2005.08.004 · Cited by 3
Adiposity and the Gut - The Role of Gut Hormones
Amber, V., & Bloom, S. R. (2007) · Current Nutrition & Food Science · doi:10.2174/1573401310703010075 · Cited by 3
Self-citation
How appetite is controlled
Wren, A., & Bloom, S. R. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200204000-00004 · Cited by 3
Self-citation
Neuropeptides and the Control of Energy Homeostasis
Woods, S. C., Rushing, P. A., & Seeley, R. J. (2001) · KARGER eBooks · doi:10.1159/000061847 · Cited by 3
Neuroendocrine Regulation of Food Intake
Dagogo-Jack, S. E. (2005) · CRC Press eBooks · doi:10.1201/9781420038798.ch1 · Cited by 3
Hypothalamic regulation of sepsis-associated anorexia: cytokine and hormonal signalling through AgRP/POMC circuits
Zhu, W., Libert, C., & Vanderhaeghen, T. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00416-6 · Cited by 2
“Upon activation, the AgRP peptide is released and promotes food intake by antagonising the MC 3 and MC 4 receptors and thereby causes hyperphagia when centrally administered (Ollmann et al, 1997; Rossi et al, 1998) or genetically overexpressed in mice (Graham et al, 1997).”
Epigenetic Mechanisms of Obesity: Insights from Transgenic Animal Models
Na, E. S. (2025) · Life · doi:10.3390/life15040653 · Cited by 2
“Overexpression in transgenic mouse models leads to hyperphagia and obesity [72], while activation or optogenetic stimulation of ARC AgRP neurons elicits spontaneous food intake in ad libitum -fed mice [71,73,74].”
The high glycemic index diet was an independent predictor to explain changes in agouti-related protein in obese adolescents.
Netto, B. D. M., Masquio, D. C. L., Campos, R. M. D. S., Sanches, P. D. L., Corgosinho, F. C., Tock, L., Oyama, L. M., de Mello, M. T., Tufik, S., & Dâmaso, A. R. (2014) · PubMed · doi:10.3305/nh.2014.29.2.7087 · Cited by 3
Current Concepts and Future Directions in the Battle Against Obesity
Niravel, A., & Smolar, E. N. (2004) · Comprehensive Therapy · doi:10.1007/s12019-004-0014-2 · Cited by 2
Functional profiling of immediate early gene Egr1 in an anorexic mouse model
Huang, J. X., Jiang, W., & Yuan, D. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1656 · Cited by 2
Neuropeptide Regulation of Appetite and Reproduction
Small, C., & Sa, S. (2004) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 2
Self-citation
Rho-kinase mediates the anorexigenic action of melanocortin by suppressing AMPKPreprint
Kim, S. S., Hwang, W. M., Yang, W., Lee, H., Park, K. S., Dagon, Y., & Kim, Y. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/677880 · Cited by 2
“…hypothalamus (PVH), amygdala, DMH, and cortex are crucial for the regulation of feeding behavior, energy expenditure, glucose homeostasis and autonomic outflow (Krashes et al., 2016, Balthasar et al., 2005, Small et al., 2001, Shah et al., 2014, Rossi et al., 1998, Huszar et al., 1997).”
Background
Effects of the combination of intermittent fasting and physical exercise on autophagic and leptin pathway in the hypothalamus of obese mice
Oliveira, L. D. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-06022023-105659 · Cited by 2
Inactivating Melanocortin 4 Receptor Mutations and Human Obesity
Tao, Y. (2007) · Humana Press eBooks · doi:10.1007/978-1-60327-139-4_3 · Cited by 1
“AgRP increases feeding and can antagonize Inactivating MC4R Mutations and Human Obesity 47 the effect of � -MSH on food intake ( 10 ).”
Background
Neural Control of Feeding and Energy Homeostasis
Caron, É., & Ahima, R. S. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_5 · Cited by 1
The Role of Central Nervous System Glucagon-Like Peptide-1 in the Regulation of Energy Balance
Barrera, J. G. (2009) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Neuroregulation of Appetite
Reizes, O., Benoit, S. C., & Clegg, D. J. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_1 · Cited by 1
Advances in energy balance & metabolism circuitry
Grajales‐Reyes, J. G. (2025) · Advances in genetics · doi:10.1016/bs.adgen.2025.02.003 · Cited by 1
Hypothalamic control of energy homeostasis
Singhal, N. S., & Ahima, R. S. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541643.004 · Cited by 1
Integrated insights into the role of alpha-melanocyte stimulatory hormone in the control of food intake and glycaemia
Al‐Najim, W., le Roux, C. W., & Docherty, N. G. (2018) · Peptides · doi:10.1016/j.peptides.2017.12.003 · Cited by 1
“Central administration of AgRP in rodents stimulates food intake and reduces energy expenditure [33,34].”
Melanocortinas y su participación en el desarrollo de la obesidad
López-Alonso, V. E., Díaz‐Urbina, D., Escartín-Pérez, R. E., & Díaz, J. M. M. (2022) · Revista Mexicana de Trastornos Alimentarios/Mexican Journal of Eating Disorders · doi:10.22201/fesi.20071523e.2020.4.643 · Cited by 1
“…en modelos animales La α-MSH (agonista endógeno de los rMC3 y de los rMC4) tiene un efecto inhibitorio sobre la ingesta de alimento y el almacenamiento de energía, en contraste la AgRP, antagonista endógeno de los rMC3/ rMC4 promueve la ingesta de alimento (Abbott et al., 2000; Rossi et al., 1998).”
Background

Authors: Rossi, M., Kim, M. S., Morgan, D. G. A., Small, C. J., Edwards, C. M. B., Sunter, D., Abusnana, S., Goldstone, A. P., Russell, S. H., Stanley, S. A., Smith, D. M., Yagaloff, K., Ghatei, M. A., & Bloom, S. R.
Affiliations: Hammersmith Hospital (GB)
ORCID: Abusnana, S.
Goldstone, A. P.
Stanley, S. A.
Smith, D. M.
Bloom, S. R.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1998-10
Volume: 139
Issue: 10
Pages: 4428-4431
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.139.10.6332
OpenAlex: W2171010063
Cited by: 576
References: 0
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 16 · 2018: 8 · 2017: 13 · 2016: 16 · 2015: 15 · 2014: 16 · 2013: 22 · 2012: 29
FWCI: 11.74
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: agouti-related protein, C-terminal fragment, alpha-melanocyte-stimulating hormone, melanocortin 3 receptor, melanocortin-4 receptor, dietary intake, hyperphagia, SHU9119, obesity, hypothalamus, cAMP signaling, intracerebroventricular administration
MeSH terms: alpha-MSH, Animals, Dose-Response Relationship, Drug, Eating, Injections, Intraventricular, Male, Peptide Fragments, Proteins, Rats, Wistar, Receptors, Corticotropin, Intercellular Signaling Peptides and Proteins, Receptor, Melanocortin, Type 3, Rats, Agouti Signaling Protein, Agouti-Related Protein

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A C-Terminal Fragment of Agouti-Related Protein Increases Feeding and Antagonizes the Effect of Alpha-Melanocyte Stimulating Hormone in Vivo

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