The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539).
Abstract
Although obesity has become the most common metabolic disorder in the developed world and is highly associated with insulin resistance and noninsulin-dependent diabetes mellitus, the molecular mechanisms underlying these disorders are not clearly understood. Tumor necrosis factor-alpha (TNF-alpha) is overexpressed in obesity and is a candidate mediator of obesity-induced insulin resistance. Complete lack of TNF-alpha function through targeted mutations in TNF-alpha gene or both of its receptors results in significant improvement of insulin sensitivity in dietary, chemical, or genetic models of rodent obesity. In this study, we have analyzed the in vivo role of TNF signaling from p55 [TNF receptor (TNFR) 1] and p75 (TNFR 2) TNFR in the development of insulin resistance by generating genetically obese mice (ob/ob) lacking p55 or p75 TNFRs. In the ob/ob mice, the absence of p55 caused a significant improvement in insulin sensitivity. p75 deficiency alone did not affect insulin sensitivity but might potentiate the effects of p55 deficiency in animals lacking both TNFRs. These results indicate that TNF-alpha is a component of insulin resistance in the ob/ob model of murine obesity and p55 TNFR is the predominant receptor mediating its actions.
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Cited by
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Inflammatory Mechanisms in Obesity
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Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
Zatterale, F., Longo, M., Naderi, J., Raciti, G. A., Desiderio, A., Miele, C., & Beguinot, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2019.01607 · Cited by 1,180
Calorie restriction, SIRT1 and metabolism: understanding longevity
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Metadata
- Authors
- Uysal, K. T., Wiesbrock, S. M., & Hotamisligil, G. S.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1998-12-01
- Volume
- 139
- Issue
- 12
- Pages
- 4832-4838
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2120282627
- Cited by
- 247
- References
- 11
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539). https://app.cochat.ai/papers/10.1210/endo.139.12.6337
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- Uysal, K. T., Wiesbrock, S. M., & Hotamisligil, G. S. (1998). Functional Analysis of Tumor Necrosis Factor (TNF) Receptors in TNF-α-Mediated Insulin Resistance in Genetic Obesity**This work is supported in part by a grant from the NIH (DK-52539). Endocrinology. https://doi.org/10.1210/endo.139.12.6337
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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