Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis in Vitro1

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909

The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene

Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B. F., Broxmeyer, H. E., & Manolagas, S. C. (1992) · Science · doi:10.1126/science.1621100 · Cited by 1,440

SRα Promoter: an Efficient and Versatile Mammalian cDNA Expression System Composed of the Simian Virus 40 Early Promoter and the R-U5 Segment of Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat

Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M., & Arai, N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.1.466-472.1988 · Cited by 1,330

A novel domain within the 55 kd TNF receptor signals cell death

Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., & Mountz, J. D. (1994) · Science · doi:10.1126/science.7510905 · Cited by 1,108

Modulation of Osteoclast Differentiation

Suda, T., Takahashi, N., & Martin, T. J. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-1-66 · Cited by 1,004

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-123-5-2600 · Cited by 934

Alendronate May Protect Against Increased Periodontitis‐Related Bone Loss in Estrogen‐Deficient Rats

Duarte, P. M., Assis, D. R. D., Casati, M. Z., Sallum, A. W., Sallum, E. A., & Nociti, F. H. (2004) · Journal of Periodontology · doi:10.1902/jop.2004.75.9.1196 · Cited by 31

Relation of soluble RANKL and osteoprotegerin levels in blood and gingival crevicular fluid to the degree of root resorption after orthodontic tooth movement

Tyrovola, J. B., Perrea, D. N., Halazonetis, D. J., Dontas, I. A., Vlachos, I. S., & Makou, M. (2010) · Journal of Oral Science · doi:10.2334/josnusd.52.299 · Cited by 31

Computer-simulated bone architecture in a simple bone-remodeling model based on a reaction-diffusion system

Tezuka, K.-I., Wada, Y., Takahashi, A., & Kikuchi, M. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-004-0533-z · Cited by 31

Effects of alkylphenols on bone metabolism in vivo and in vitro

Hagiwara, H., Sugizaki, T., Tsukamoto, Y., Senoh, E., Goto, T., & Ishihara, Y. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.06.863 · Cited by 31

Increased bone resorption may play a crucial role in the occurrence of osteopenia in patients with type 2 diabetes: Possible involvement of accelerated polyol pathway in its pathogenesis

Takizawa, M., Suzuki, K., Matsubayashi, T., Kikuyama, M., Suzuki, H., Takahashi, K., Katsuta, H., Mitsuhashi, J., Nishida, S., Yamaguchi, S., et al. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.07.008 · Cited by 33

Protein kinase-A-dependent osteoprotegerin production on interleukin-1 stimulation in human gingival fibroblasts is distinct from periodontal ligament fibroblasts

Hormdee, D., Nagasawa, T., Kiji, M., Yashiro, R., Kobayashi, H., Koshy, G., Noguchi, K., Nitta, H., & Ishikawa, I. (2005) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2005.02937.x · Cited by 31

Locally administered T cells from mice immunized with lipopolysaccharide (LPS) accelerate LPS-induced bone resorption

Ozaki, Y., Ukai, T., Yamaguchi, M., Yokoyama, M., Haro, E. R. A., Yoshimoto, M., Kaneko, T., Yoshinaga, M., Nakamura, H., Shiraishi, C., et al. (2009) · Bone · doi:10.1016/j.bone.2009.01.375 · Cited by 31

Recombinant human thyroid stimulating hormone does not acutely change serum osteoprotegerin and soluble receptor activator of nuclear factor-?? ligand in patients under evaluation for differentiated thyroid carcinoma*

Giusti, M., Cecoli, F., Ghiara, C., Rubinacci, A., Villa, I., Cavallero, D., Mazzuoli, L., Mussap, M., Lanzi, R., & Minuto, F. M. (2007) · HORMONES · doi:10.14310/horm.2002.1111026 · Cited by 31

Changes in the Serum Growth Factors and Osteoprotegerin after Bone Marrow Transplantation: Impact on Bone and Mineral Metabolism

Baek, K. H., Lee, W., Oh, K. W., Kim, H. S., Han, J. H., Kang, M. I., Cha, B. Y., Lee, K. W., Son, H., Kang, S. K., et al. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031206 · Cited by 31

Effects of ageing on proliferative ability, and the expressions of secreted protein, acidic and rich in cysteine (SPARC) and osteoprotegerin (osteoclastogenesis inhibitory factor) in cultures of human periodontal ligament cells

Shiba, H., Nakanishi, K., Sakata, M., Fujita, T., Uchida, Y., & Kurihara, H. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00140-8 · Cited by 31

Emerging therapies for osteoporosis

Gowen, M., Emery, J. G., & Kumar, S. (2000) · Emerging Drugs · doi:10.1517/14728214.5.1.1 · Cited by 31

Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin

Kwilas, A. R., Ardiani, A., Gameiro, S. R., Richards, J., Hall, A. B., & Hodge, J. W. (2016) · Oncotarget · doi:10.18632/oncotarget.8274 · Cited by 30

Cytokine Expression in Feline Osteoclastic Resorptive Lesions

DeLaurier, A., Allen, S., Deflandre, C., Horton, M. A., & Price, J. S. (2002) · Journal of Comparative Pathology · doi:10.1053/jcpa.2002.0577 · Cited by 30

Brain and Bone: Central Regulation of Bone Mass

Haberland, M., Schilling, A. F., Rueger, J. M., & Amling, M. (2001) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-200112000-00016 · Cited by 29

Is RANKL a potential molecular target in osteoarthritis?

Muratovic, D., Atkins, G. J., & Findlay, D. M. (2023) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2023.10.010 · Cited by 30

Mouse Genetics Have Uncovered New Paradigms in Bone Biology

Günther, T., & Schinke, T. (2000) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(00)00256-3 · Cited by 31

Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cells

Mogi, M., & Kondo, A. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.084 · Cited by 29

Osteoclast and Osteoblast Activities on Carbonate Apatite Plates in Cell Cultures

Kanayama, K., Sriarj, W., Shimokawa, H., Ohya, K., Doi, Y., & Shibutani, T. (2010) · Journal of Biomaterials Applications · doi:10.1177/0885328210374672 · Cited by 29

Differentiation of osteoclast precursors on gellan gum-based spongy-like hydrogels for bone tissue engineering

Maia, F. R., Musson, D. S., Naot, D., da Silva, L. P., Bastos, A. R., Costa, J. B., Oliveira, J. M., Correlo, V. M., Reis, R. L., & Cornish, J. (2018) · Biomedical Materials · doi:10.1088/1748-605x/aaaf29 · Cited by 29

Osteoblastic heparan sulfate regulates osteoprotegerin function and bone mass

Nozawa, S., Inubushi, T., Irie, F., Takigami, I., Matsumoto, K., Shimizu, K., Akiyama, H., & Yamaguchi, Y. (2018) · JCI Insight · doi:10.1172/jci.insight.89624 · Cited by 28

Murine osteoclasts secrete serine protease HtrA1 capable of degrading osteoprotegerin in the bone microenvironment

Ochiai, N., Nakachi, Y., Yokoo, T., Ichihara, T., Eriksson, T., Yonemoto, Y., Kato, T., Ogata, H., Fujimoto, N., Kobayashi, Y., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0334-5 · Cited by 30

Polyethylene Particle–Induced Bone Resorption in α-Calcitonin Gene–Related Peptide–Deficient Mice

Wedemeyer, C., Neuerburg, C., Pfeiffer, A., Heckelei, A., Bylski, D., von Knoch, F., Schinke, T., Hilken, G., Gosheger, G., von Knoch, M., et al. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070408 · Cited by 29

B Cells Play an Important Role in Lipopolysaccharide-Induced Bone Resorption

Kozuka, Y., Ozaki, Y., Ukai, T., Kaneko, T., & Hara, Y. (2006) · Calcified Tissue International · doi:10.1007/s00223-005-0149-x · Cited by 27

A novel promoter regulates calcitonin receptor gene expression in human osteoclasts

Shen, Z., Crotti, T. N., Flannery, M. R., Matsuzaki, K., Goldring, S. R., & McHugh, K. P. (2007) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2007.08.005 · Cited by 27

Osteoprotegerin Levels in Primary Hyperparathyroidism: Effect of Parathyroidectomy and Association with Bone Metabolism

Stilgren, L. S., Heged�s, L., Beck‐Nielsen, H., & Abrahamsen, B. (2003) · Calcified Tissue International · doi:10.1007/s00223-002-2100-8 · Cited by 29

OPG, RANKL, and RANK in Cancer Metastasis: Expression and Regulation

Brown, J. M., Zhang, J., & Keller, E. T. (2004) · Cancer treatment and research · doi:10.1007/978-1-4419-9129-4_7 · Cited by 28

Cloning and characterization of the gene encoding mouse osteoclast differentiation factor

Kodaira, K., Kodaira, K., Mizuno, A., Yasuda, H., Shima, N., Murakami, A., Ueda, M., & Higashio, K. (1999) · Gene · doi:10.1016/s0378-1119(99)00025-6 · Cited by 29

Osteoimmunology and Bone Homeostasis: Relevance to Spondyloarthritis

Goldring, S. R. (2013) · Current Rheumatology Reports · doi:10.1007/s11926-013-0342-2 · Cited by 28

IL-3 Differentially Regulates Membrane and Soluble RANKL in Osteoblasts through Metalloproteases and the JAK2/STAT5 Pathway and Improves the RANKL/OPG Ratio in Adult Mice

Singh, K., Piprode, V., Mhaske, S. T., Barhanpurkar, A. P., & Wani, M. R. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1601528 · Cited by 28

TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?

Bernardi, S., Voltan, R., Rimondi, E., Melloni, E., Milani, D., Cervellati, C., Gemmati, D., Celeghini, C., Secchiero, P., Zauli, G., et al. (2019) · Clinical Science · doi:10.1042/cs20181116 · Cited by 29

Effects of low dietary phosphorus on tibia quality and metabolism in caged laying hens

Teng, X., Zhang, W., Xu, D., Liu, Z., Yang, N., Luo, D., Wang, H., Ge, M., & Zhang, R. (2020) · Preventive Veterinary Medicine · doi:10.1016/j.prevetmed.2020.105049 · Cited by 29

Control of bone development by P2X and P2Y receptors expressed in mesenchymal and hematopoietic cells.

Lenertz, L. Y., Baughman, C. J., Waldschmidt, N. V., Thaler, R., & van Wijnen, A. J. (2015) · Gene · doi:10.1016/j.gene.2015.06.031 · Cited by 28

Expression of Toll‐like receptors 2 and 4 and the OPG – RANKL – RANK system in inflammatory external root resorption and external cervical resorption

Lin, Y. P., Love, R. M., Friedlander, L. T., Shang, H.-S., & Pai, M.-H. (2013) · International Endodontic Journal · doi:10.1111/iej.12088 · Cited by 28

Loss of Protein Kinase C-δ Protects against LPS-Induced Osteolysis Owing to an Intrinsic Defect in Osteoclastic Bone Resorption

Khor, E. C., Abel, T. N., Tickner, J. C., Chim, S. M., Wang, C., Cheng, T., Ng, B., Ng, P. Y., Teguh, D. A., Kenny, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070815 · Cited by 30

Inhibition of RANK/RANKL signal transduction pathway: A promising approach for osteoporosis treatment

Bai, Y., Yang, F., Xuan, K., Bai, Y.-X., & Wu, B. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.03.021 · Cited by 29

Anorganic bovine bone and a silicate-based synthetic bone activate different microRNAs

Palmieri, A., Pezzetti, F., Zollino, I., Avantaggiato, A., Scapoli, L., Martinelli, M., Arlotti, M., Masiero, E., & Carinci, F. (2008) · Journal of Oral Science · doi:10.2334/josnusd.50.301 · Cited by 28

Cardiac hypertrophy is exacerbated in aged mice lacking the osteoprotegerin gene

Hao, Y., Tsuruda, T., Sekita‐Hatakeyama, Y., Kurogi, S., Kubo, K., Sakamoto, S., Nakamura, M., Udagawa, N., Sekimoto, T., Hatakeyama, K., et al. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw025 · Cited by 27

The Role of Hormones in the Regulation of Bone Turnover and Eggshell Calcification

Dacke, C. G., Sugiyama, T., & Gay, C. V. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-407160-5.00025-7 · Cited by 28

SPARC stimulates the synthesis of OPG/OCIF, MMP‐2 and DNA in human periodontal ligament cells

Fujita, T., Shiba, H., Sakata, M., Uchida, Y., Nakamura, S., & Kurihara, H. (2002) · Journal of Oral Pathology and Medicine · doi:10.1034/j.1600-0714.2002.00188.x · Cited by 28

Bone cement extracts modulate the osteoprotegerin/osteoprotegerin-ligand expression in MG63 osteoblast-like cells

Granchi, D. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00371-4 · Cited by 28

p44/42 MAPK activation is necessary for receptor activator of nuclear factor-κB ligand induction by high extracellular calcium

Kim, Y., Kim, J., Kim, S. N., Kim, G.-S., & Baek, J. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)00661-2 · Cited by 28

Bone biology

Fuchs, R. K., Thompson, W. R., & Warden, S. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-08-102451-5.00002-0 · Cited by 36

Molecular and cellular basis of bone resorption

Gruber, R. (2014) · Wiener Medizinische Wochenschrift · doi:10.1007/s10354-014-0310-0 · Cited by 27

Glycosaminoglycans inhibit the adherence and the spreading of osteoclasts and their precursors: Role in osteoclastogenesis and bone resorption

Baud’huin, M., Ruiz-Velasco, C., Jégo, G., Charrier, C., Gasiunas, N., Gallagher, J. T., Maillasson, M., Naggi, A., Padrines, M., Rédiní, F., et al. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.08.001 · Cited by 27

A comparative study on BMP-induced osteoclastogenesis and osteoblastogenesis in primary cultures of adult rat bone marrow cells

Paul, S., Lee, J. C., & Yeh, L. C. (2009) · Growth Factors · doi:10.1080/08977190802707324 · Cited by 27

Osteoprotegerin-Knockout Mice Developed Early Onset Root Resorption

Liu, Y. F., Du, H., Wang, Y., Liu, M., Deng, S., Fan, L., Zhang, L., Sun, Y., & Zhang, Q. (2016) · Journal of Endodontics · doi:10.1016/j.joen.2016.07.008 · Cited by 27

Charcot Neuroarthropathy: From the Laboratory to the Bedside

Pitocco, D., Scavone, G., Leo, M. A. S. D., Vitiello, R., Rizzi, A., Tartaglione, L., Costantini, F., Flex, A., Galli, M., Caputo, S., et al. (2019) · Current Diabetes Reviews · doi:10.2174/1573399815666190502121945 · Cited by 27

A Single‐Nucleotide Polymorphism in the Gene Encoding Osteoprotegerin, an Anti‐inflammatory Protein Produced in Response to Infection with DiarrheagenicEscherichia coli,Is Associated with an Increased Risk of Nonsecretory Bacterial Diarrhea in North American Travelers to Mexico

Jamal, M. A., DuPont, H. L., Jiang, Z., Flores, J., Carlin, L. G., Belkind‐Gerson, J., Martinez‐Sandoval, F., Guo, D., White, A. C., & Okhuysen, P. C. (2009) · The Journal of Infectious Diseases · doi:10.1086/596319 · Cited by 27

Regulation of secretion of osteoprotegerin in rat dental follicle cells

Wise, G. E., Ding, D., & Yao, S. (2004) · European Journal Of Oral Sciences · doi:10.1111/j.1600-0722.2004.00156.x · Cited by 27

Characterization of Immortalized Osteoclast Precursors Developed from Mice Transgenic for Both bcl-XL and Simian Virus 40 Large T Antigen

Hentunen, T. A., Jackson, S. H., Chung, H.-Y., Reddy, S. V., Lorenzo, J., Choi, S. J., & Roodman, G. D. (1999) · Endocrinology · doi:10.1210/endo.140.7.6867 · Cited by 27

Osteoclastogenesis Inhibitory Factor/Osteoprotegerin Reduced Bone Loss Induced by Mechanical Unloading

Ichinose, Y., Tanaka, H., Inoue, M., Mochizuki, S., Tsuda, E., & Seino, Y. (2004) · Calcified Tissue International · doi:10.1007/s00223-004-0028-x · Cited by 26

Differentially expressed genes and signalling pathways are involved in mouse osteoblast-like MC3T3-E1 cells exposed to 17-β estradiol

Shang, Z., Li, X., Sun, H. Q., Xiao, G.-N., Wang, C., & Gong, Q. (2014) · International Journal of Oral Science · doi:10.1038/ijos.2014.2 · Cited by 26

Acidosis Inhibits Mineralization in Human Osteoblasts

Takeuchi, S., Hirukawa, K., & Togari, A. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9746-2 · Cited by 26

Comparison of osteoclast precursors in peripheral blood mononuclear cells from rheumatoid arthritis and osteoporosis patients

Nose, M., Yamazaki, H., Hagino, H., Morio, Y., Hayashi, S., & Teshima, R. (2008) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-008-0011-0 · Cited by 26

Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin

Sugisaki, R., Miyamoto, Y., Yoshimura, K., Sasa, K., Kaneko, K. J., Tanaka, M., Itose, M., Inoue, S., Baba, K., Shirota, T., et al. (2019) · Bone · doi:10.1016/j.bone.2019.115216 · Cited by 26

Osteoprotegerin induces cytoskeletal reorganization and activates FAK, Src, and ERK signaling in endothelial cells

Kobayashi‐Sakamoto, M., Isogai, E., & Holen, I. (2010) · European Journal Of Haematology · doi:10.1111/j.1600-0609.2010.01446.x · Cited by 26

The PCa Tumor Microenvironment

Sottnik, J. L., Zhang, J., Macoska, J. A., & Keller, E. T. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0073-8 · Cited by 27

Age‐Related and Surgically Induced Estrogen Deficiencies May Differently Affect Bone Around Titanium Implants in Rats

Duarte, P. M., Gonçalves, P. F., Casati, M. Z., Sallum, E. A., & Nociti, F. H. (2005) · Journal of Periodontology · doi:10.1902/jop.2005.76.9.1496 · Cited by 26

Therapeutic effect of aqueous extract from Ecliptae herba on bone metabolism of ovariectomized rats

Zhang, Z., Bai, D., Liu, M.-J., Li, Y., Pan, J., Liu, H., Wang, W., Xiang, L., Xiao, G. G., & Ju, D. (2012) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e318265e7dd · Cited by 26

Expression, Purification, and Characterization of the Human Receptor Activator of NF-κB Ligand (RANKL) Extracellular Domain

Willard, D. H., Chen, W., Barrett, G. B., Blackburn, K., Bynum, J. M., Consler, T. G., Hoffman, C. R., Horne, E., Iannone, M. A., Kadwell, S. H., et al. (2000) · Protein Expression and Purification · doi:10.1006/prep.2000.1278 · Cited by 26

Markers of bone turnover in patients with epilepsy and their relationship to management of bone diseases induced by antiepileptic drugs

Hamed, S. A. (2015) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1123617 · Cited by 27

Therapeutic Targets of the TNF Superfamily

Grewal, I. S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-89520-8 · Cited by 26

Low Calcium Environment Effects Osteoprotegerin Ligand/Osteoclast Differentiation Factor

Takeyama, S., Yoshimura, Y., Shirai, Y., Deyama, Y., Hasegawa, T., Yawaka, Y., Kikuiri, T., Matsumoto, A., & Fukuda, H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3498 · Cited by 25

Phytate inhibits bovine pericardium calcification in vitro

Grases, F., Sanchís, P., Costa‐Bauzá, A., Bonnín, O., Isern, B., Perelló, J., & Prieto, R. (2007) · Cardiovascular Pathology · doi:10.1016/j.carpath.2007.08.005 · Cited by 26

Effect of pre-exercise and post-exercise creatine supplementation on bone mineral content and density in healthy aging adults

Candow, D. G., Forbes, S. C., & Vogt, E. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.01.025 · Cited by 25

Creatine monohydrate supplementation for older adults and clinical populations

Candow, D. G., Ostojić, S. M., Chilibeck, P. D., Longobardi, I., Gualano, B., Tarnopolsky, M. A., Wallimann, T., Moriarty, T. A., Kreider, R. B., Forbes, S. C., et al. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2534130 · Cited by 37

Effect of cyclic mechanical loading on osteoclast recruitment in periodontal tissue

Nozaki, K., Kaku, M., Yamashita, Y., Yamauchi, M., & Miura, H. (2009) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2008.01193.x · Cited by 25

Effects of lactoferrin on bone resorption of midpalatal suture during rapid expansion in rats

Cheng, Y., Sun, J., Zhou, Z., Pan, J., Zou, S., & Chen, J. (2018) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2017.09.020 · Cited by 25

Osteoprotective effects of flavonoids: Evidence from in vivo and in vitro studies (Review)

Cao, L., Wang, J., Zhang, Y., Tian, F., & Wang, C. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12716 · Cited by 26

The G60S connexin 43 mutation activates the osteoblast lineage and results in a resorption-stimulating bone matrix and abrogation of old-age–related bone loss

Zappitelli, T., Chen, F., Moreno, L., Zirngibl, R. A., Grynpas, M. D., Henderson, J. E., & Aubin, J. E. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1965 · Cited by 25

Uremic toxin and bone metabolism

Iwasaki, Y., Yamato, H., Nii‐Kono, T., Fujieda, A., Uchida, M., Hosokawa, A., Motojima, M., & Fukagawa, M. (2006) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-005-0667-7 · Cited by 25

Intima-media thickness of the carotid arteries is related to serum osteoprotegerin levels in healthy postmenopausal women

Erdogan, B., Aslan, E., Bağış, T., Gökçel, A., Erkanlı, S., Bavbek, M., & Altınörs, N. (2004) · Neurological Research · doi:10.1179/016164104225014157 · Cited by 25

Transcriptional control of osteoblast differentiation and function

Karsenty, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00007-5 · Cited by 25

Modulation of the Effects of Osteoprotegerin (OPG) Ligand in a Human Leukemic Cell Line by OPG and Calcitonin

Mancini, L., Moradi‐Bidhendi, N., Brandi, M. L., Perretti, M., & MacIntyre, I. M. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3953 · Cited by 25

Evidence of a role for RANKL in the development of myeloma bone disease

DELEENHEER, E. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2004.03.011 · Cited by 26

Osteoclastogenesis inhibitory factor/osteoprotegerin ameliorates the decrease in both bone mineral density and bone strength in immobilized rats.

Mochizuki, S.-I., Fujise, N., Higashio, K., & Tsuda, E. (2002) · Journal of Bone and Mineral Metabolism · doi:10.1007/s774-002-8441-x · Cited by 24

Effects of JSOG-6 on protection against bone loss in ovariectomized mice through regulation of osteoblast differentiation and osteoclast formation

Chung, H., Cho, L., Shin, J., Lee, J., Ha, I., Park, H. J., & Lee, S. K. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-184 · Cited by 24

Denosumab

Lipton, A., & Jacobs, I. A. (2011) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e328349731c · Cited by 25

A DNA microarray analysis of chemokine and receptor genes in the rat dental follicle—Role of secreted frizzled-related protein-1 in osteoclastogenesis

Liu, D., & Wise, G. E. (2007) · Bone · doi:10.1016/j.bone.2007.04.181 · Cited by 24

Influences of bone and mineral metabolism in epilepsy

Hamed, S. A. (2011) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2011.534455 · Cited by 24

Osteoprotegerin (OPG) and receptor activator of NF-kB ligand (RANK-L) serum levels in patients on chronic hemodialysis

Gonnelli, S., Montagnani, A., Caffarelli, C., Cadirni, A., Campagna, M. S., Franci, M. B., Lucani, B., Gaggiotti, E., & Nuti, R. (2005) · Journal of Endocrinological Investigation · doi:10.1007/bf03347242 · Cited by 24

Multifunctional Properties of RANKL/RANK in Cell Differentiation, Proliferation and Metastasis

Kukita, A., & Kukita, T. (2013) · Future Oncology · doi:10.2217/fon.13.115 · Cited by 24

Riboflavin and photoproducts in MC3T3-E1 differentiation

Chaves-Neto, A. H., Yano, C. L., Paredes‐Gamero, E. J., Machado, D., Justo, G. Z., Peppelenbosch, M. P., & Ferreira, C. V. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.07.026 · Cited by 24

Bone anatomy, physiology and adaptation to mechanical loading

Fuchs, R. K., Warden, S. J., & Turner, C. H. (2009) · Elsevier eBooks · doi:10.1533/9781845696610.1.25 · Cited by 32

Osteoprotegerin protects endothelial cells against apoptotic cell death induced byPorphyromonas gingivaliscysteine proteinases

Kobayashi‐Sakamoto, M., Hirose, K., Nishikata, M., Isogai, E., & Chiba, I. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00458.x · Cited by 24

Studies in Paget's disease and their relevance to oncology

Roodman, G. D. (2001) · Seminars in Oncology · doi:10.1016/s0093-7754(01)90227-1 · Cited by 24

Inflammatory cells and bone loss in rheumatoid arthritis

Haynes, D. R. (2007) · Arthritis Research & Therapy · doi:10.1186/ar2213 · Cited by 24

Effects of surface morphology and composition of titanium implants on osteogenesis and inflammatory responses: a review

Ji, Z., Wan, Y., Wang, H., Yu, M., Zhao, Z., Wang, T., Ma, G., Fan, S., & Liu, Z. (2023) · Biomedical Materials · doi:10.1088/1748-605x/acd976 · Cited by 23

Electroacupuncture at the governor vessel and bladder meridian acupoints improves postmenopausal osteoporosis through osteoprotegerin/RANKL/RANK and Wnt/β-catenin signaling pathways

Zheng, X., Wu, G., Nie, Y. G., & Lin, Y. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2553 · Cited by 23

Arctigenin suppresses receptor activator of nuclear factor κB ligand (RANKL)-mediated osteoclast differentiation in bone marrow-derived macrophages.

Kim, A., Kim, H., Lee, J., Choi, J.-H., Kim, S. N., Kim, D. K., Kim, J. H., Mun, S., Kim, J.-W., Jeon, H., et al. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.02.026 · Cited by 21

Osteoprotegerin is present on the membrane of osteoclasts isolated from mouse long bones

Woo, K. M., Choi, Y., Ko, S., Ko, J. S., Oh, K., & Kim, K.-K. (2002) · Experimental & Molecular Medicine · doi:10.1038/emm.2002.49 · Cited by 23

Casein hydrolysates enhance osteoblast proliferation and differentiation in mouse bone marrow culture

Behera, P., Kumar, R., Sandeep, I. V. R., Kapila, R., Dang, A., & Kapila, S. (2013) · Food Bioscience · doi:10.1016/j.fbio.2013.03.008 · Cited by 22

Angiotensin II Stimulation of Cardiac Hypertrophy and Functional Decompensation in Osteoprotegerin-Deficient Mice

Tsuruda, T., Sekita‐Hatakeyama, Y., Hao, Y., Sakamoto, S., Kurogi, S., Nakamura, M., Udagawa, N., Funamoto, T., Sekimoto, T., Hatakeyama, K., et al. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06689 · Cited by 23

Epigenetic control of mouse receptor activator of NF-κB ligand gene expression

Kitazawa, S., & Kitazawa, R. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00189-4 · Cited by 23

High osteoprotegerin serum levels in primary biliary cirrhosis are associated with disease severity but not with the mRNA gene expression in liver tissue

Guañabens, N., Enjuanes, A., Álvarez, L., Peris, P., Caballería, L., de Osaba, M. J. M., Cerdá, D., Monegal, A., Pons, F., & Parés, A. R. (2009) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-009-0042-1 · Cited by 23

Osteoclastogenesis inhibitory factor/osteoprotegerin in synovial fluid from patients with temporomandibular disorders

Kaneyama, K., Segami, N., Nishimura, M., Sato, J., Suzuki, T., & Fujimura, K. (2003) · International Journal of Oral and Maxillofacial Surgery · doi:10.1054/ijom.2002.0363 · Cited by 23

LTB4 Can Directly Stimulate Human Osteoclast Formation from PBMC Independent of RANKL

Jiang, J., Lv, H., Lin, J., Jiang, D., & Chen, Z. (2005) · Artificial Cells Blood Substitutes and Biotechnology · doi:10.1080/10731190500289784 · Cited by 23

Runx-2 is not essential for the vitamin D-regulated expression of RANKL and osteoprotegerin in osteoblastic cells

Notoya, M., Otsuka, E., Yamaguchi, A., & Hagiwara, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.101 · Cited by 23

GH replacement therapy increases plasma osteoprotegerin levels in GH-deficient adults

Lanzi, R., Losa, M., Villa, I., Gatti, E., Sirtori, M., Fiume, C. D., & Rubinacci, A. (2003) · European Journal of Endocrinology · doi:10.1530/eje.0.1480185 · Cited by 23

Parathyroid hormone decreases endothelial osteoprotegerin secretion: role of protein kinase A and C

Rashid, G., Plotkin, E., Klein, O., Green, J., Bernheim, J., & Benchetrit, S. (2008) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00622.2007 · Cited by 23

A novel molecular mechanism modulating osteoclast differentiation and function

Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Goto, M., Mochizuki, S.-I., Tsuda, E., Morinaga, T., Udagawa, N., et al. (1999) · Bone · doi:10.1016/s8756-3282(99)00121-0 · Cited by 264

Osteoclast Differentiation Factor is a Ligand for Osteoprotegerin / Osteoclastogenesis-Inhibitory Factor

Shima, N., Yasuda, H., Nakagawa, N., Yamaguchi, K., Tsuda, E., Morinaga, T., Suda, T., & Higashio, K. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46869-7_43 · Cited by 1

Recent Advance in Osteoclastogenesis Inhibitory Factor.

Zhi, H. (2000) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

16. Lack of antagonist activity of melanocyte-stimulating hormone (MSH) on the actions of IL-1 on human bone-derived osteoblast-like cells

Evans, D., Thavarajah, M., & Kanis, J. A. (1991) · Bone · doi:10.1016/8756-3282(91)90112-v

Transforming Growth Factor-β Stimulates the Production of Osteoprotegerin/Osteoclastogenesis Inhibitory Factor by Bone Marrow Stromal Cells

Takai, H., Kanematsu, M., Yano, K., Tsuda, E., Higashio, K., Ikeda, K., Watanabe, K., & Yamada, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27091 · Cited by 299