The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesis in Vitro1
Abstract
The morphogenesis and remodeling of bone depends on the integrated activity of osteoblasts that form bone and osteoclasts that resorb bone. We previously reported the isolation of a new cytokine termed osteoclastogenesis inhibitory factor, OCIF, which specifically inhibits osteoclast development. Here we report the cloning of a complementary DNA of human OCIF. OCIF is identical to osteoprotegerin (OPG), a soluble member of the tumor-necrosis factor receptor family that inhibits osteoclastogenesis. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number in normal rats. Osteoblasts or bone marrow-derived stromal cells support osteoclastogenesis through cell-to-cell interactions. A single class of high affinity binding sites for OPG/OCIF appears on a mouse stromal cell line, ST2, in response to 1,25-dihydroxyvitamin D3. An anti-OPG/OCIF antibody that blocks the binding abolishes the biological activity of OPG/OCIF. When the sites are blocked with OPG/OCIF, ST2 cells fail to support osteoclastogenesis. These results suggest that the sites are involved in cell-to-cell signaling between stromal cells and osteoclast progenitors and that OPG/OCIF inhibits osteoclastogenesis by interrupting the signaling through the sites.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“OPG is an atypical member of the TNF receptor family in that it is a secreted protein with no transmembrane domain and no direct signaling properties (4,6).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [6]
Citations
Cites
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736
The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909
Yoshida, H., Hayashi, S.-I., Kunisada, T., Ogawa, M., Nishikawa, S., Okamura, H., Sudo, T., Shultz, L. D., & Nishikawa, S.-I. (1990) · Nature · doi:10.1038/345442a0 · Cited by 1,789
Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6
Jilka, R. L., Hangoc, G., Girasole, G., Passeri, G., Williams, D. C., Abrams, J. S., Boyce, B. F., Broxmeyer, H. E., & Manolagas, S. C. (1992) · Science · doi:10.1126/science.1621100 · Cited by 1,440
Takebe, Y., Seiki, M., Fujisawa, J., Hoy, P., Yokota, K., Arai, K., Yoshida, M., & Arai, N. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.1.466-472.1988 · Cited by 1,330
A novel domain within the 55 kd TNF receptor signals cell death
Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290
Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule
Cheng, J., Zhou, T., Liu, C., Shapiro, J. P., Brauer, M. J., Kiefer, M. C., Barr, P. J., & Mountz, J. D. (1994) · Science · doi:10.1126/science.7510905 · Cited by 1,108
Modulation of Osteoclast Differentiation
Suda, T., Takahashi, N., & Martin, T. J. (1992) · Endocrine Reviews · doi:10.1210/edrv-13-1-66 · Cited by 1,004
OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION
Takahashi, N., Akatsu, T., Udagawa, N., Sasaki, T., Yamaguchi, A., Moseley, J. M., Martin, T. J., & Suda, T. (1988) · Endocrinology · doi:10.1210/endo-123-5-2600 · Cited by 934
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 999
A novel molecular mechanism modulating osteoclast differentiation and function
Yasuda, H., Shima, N., Nakagawa, N., Yamaguchi, K., Kinosaki, M., Goto, M., Mochizuki, S.-I., Tsuda, E., Morinaga, T., Udagawa, N., et al. (1999) · Bone · doi:10.1016/s8756-3282(99)00121-0 · Cited by 264
Self-citationClines, G. A., & Guise, T. A. (2005) · Endocrine Related Cancer · doi:10.1677/erc.1.00543 · Cited by 255
Pathogenesis of bone erosions in rheumatoid arthritis
Goldring, S. R., & Gravallese, E. M. (2000) · Current Opinion in Rheumatology · doi:10.1097/00002281-200005000-00006 · Cited by 243
Suda, T., Ueno, Y., Fujii, K., & Shinki, T. (2003) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10331 · Cited by 248
Tsukii, K., Shima, N., Mochizuki, S.-I., Yamaguchi, K., Kinosaki, M., Yano, K., Shibata, O., Udagawa, N., Yasuda, H., Suda, T., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8610 · Cited by 237
Self-citationDiscovery of the RANKL/RANK/OPG system
Yasuda, H. (2021) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01175-1 · Cited by 251
Self-citationOsteoprotegerin Serum Levels in Men: Correlation with Age, Estrogen, and Testosterone Status
Szulc, P., Hofbauer, L. C., Heufelder, A. E., Roth, S., & Delmas, P. D. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7657 · Cited by 250
Wright, L. M., Maloney, W. J., YU, X., Kindle, L., Collin‐Osdoby, P., & Osdoby, P. (2005) · Bone · doi:10.1016/j.bone.2005.01.021 · Cited by 232
TRANCE is a TNF family member that regulates dendritic cell and osteoclast function
Wong, B. R., Josien, R., & Choi, Y. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.6.715 · Cited by 230
Proinflammatory cytokine (TNFα/IL‐1α) induction of human osteoclast formation
Kudo, O., Fujikawa, Y., Itonaga, I., Sabokbar, A., Torisu, T., & Athanasou, N. (2002) · Journal of Pathology · doi:10.1002/path.1190 · Cited by 193
Genetic control of skeletal development
Wagner, E. F., & Karsenty, G. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00228-8 · Cited by 229
Cundy, T. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.18.2119 · Cited by 228
IL-1 plays an important role in the bone metabolism under physiological conditions
Lee, Y.-M., Fujikado, N., Manaka, H., Yasuda, H., & Iwakura, Y. (2010) · International Immunology · doi:10.1093/intimm/dxq431 · Cited by 226
Self-citationEswarakumar, V. P., Horowitz, M. C., Locklin, R. M., Morriss‐Kay, G. M., & Lonai, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405031101 · Cited by 224
Kovács, B., Vajda, E., & Nagy, E. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184653 · Cited by 224
Estrogen Inhibits Vascular Calcification via Vascular RANKL System
Osako, M. K., Hironori Nakagami, A., Koibuchi, N., Shimizu, H., Nakagami, F., Koriyama, H., Shimamura, M., Miyake, T., Rakugi, H., & Morishita, R. (2010) · Circulation Research · doi:10.1161/circresaha.110.216846 · Cited by 222
Pathogenesis of Age-Related Bone Loss in Humans
Khosla, S. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls163 · Cited by 222
Role of RANKL and RANK in bone loss and arthritis
Jones, D. H., Kong, Y.-Y., & Penninger, J. M. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.suppl_2.ii32 · Cited by 225
Itoh, K., Udagawa, N., Katagiri, T., Iemura, S., Ueno, N., Yasuda, H., Higashio, K., Quinn, J. M. W., Gillespie, M. T., Martin, T. J., et al. (2001) · Endocrinology · doi:10.1210/endo.142.8.8300 · Cited by 250
Self-citationOsteoimmunology: Crosstalk Between the Immune and Bone Systems
Nakashima, T., & Takayanagi, H. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9316-6 · Cited by 218
HOROWITZ, M., Xi, Y., WILSON, K., & Kacena, M. A. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00030-7 · Cited by 215
Liu, W. X., & Zhang, X. (2014) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3152 · Cited by 223
Rogers, A., & Eastell, R. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0794 · Cited by 215
Ikeda, T., Kasai, M., Utsuyama, M., & Hirokawa, K. (2001) · Endocrinology · doi:10.1210/endo.142.4.8070 · Cited by 215
Zhang, Q., Chen, B., Yan, F., Guo, J., Zhu, X., Ma, S., & Yang, W. R. (2014) · BioMed Research International · doi:10.1155/2014/284836 · Cited by 223
Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage
Hastürk, H., Kantarcı, A., & Dyke, T. E. V. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00118 · Cited by 215
Togari, A. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10121 · Cited by 211
Interaction between osteoblast and osteoclast: impact in bone disease.
Phan, T. C. A., Xu, J., & Zheng, M. (2004) · PubMed · doi:10.14670/hh-19.1325 · Cited by 213
Osteopontin Facilitates Angiogenesis, Accumulation of Osteoclasts, and Resorption in Ectopic Bone
Asou, Y., Rittling, S. R., Yoshitake, H., Tsuji, K., Shinomiya, K., Nifuji, A., Denhardt, D. T., & Noda, M. (2001) · Endocrinology · doi:10.1210/endo.142.3.8006 · Cited by 205
Kawaguchi, H., Manabe, N., Miyaura, C., Chikuda, H., Nakamura, K., & Kuro‐o, M. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5705 · Cited by 204
Bone Aging, Cellular Senescence, and Osteoporosis
Pignolo, R. J., Law, S. F., & Chandra, A. (2021) · JBMR Plus · doi:10.1002/jbm4.10488 · Cited by 217
Molecular mechanisms and clinical management of cancer bone metastasis
Wang, M., Xia, F., Wei, Y., & Wei, X. (2020) · Bone Research · doi:10.1038/s41413-020-00105-1 · Cited by 204
Bortezomib inhibits human osteoclastogenesis
von Metzler, I., Krebbel, H., Hecht, M., Manz, R., Fleissner, C., Mieth, M., Kaiser, M., Jakob, C., Sterz, J., Kleeberg, L., et al. (2007) · Leukemia · doi:10.1038/sj.leu.2404806 · Cited by 197
Prostate Carcinoma Skeletal Metastases: Cross-talk between Tumor and Bone
Keller, E. T., Zhang, J., Cooper, C. R., Smith, P. C., McCauley, L. K., Pienta, K. J., & Taichman, R. S. (2001) · Cancer and Metastasis Reviews · doi:10.1023/a:1015599831232 · Cited by 200
Cao, J., Wronski, T. J., Iwaniec, U. T., Phleger, L., Kurimoto, P., Boudignon, B. M., & Halloran, B. P. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050503 · Cited by 197
Murakami, T., Yamamoto, M., Yamamoto, M., Ono, K., Nishikawa, M., Nagata, N., Motoyoshi, K., & Akatsu, T. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9723 · Cited by 195
Saika, M., Inoue, D., Kido, S., & Matsumoto, T. (2001) · Endocrinology · doi:10.1210/endo.142.6.8220 · Cited by 194
Polymorphisms in the Osteoprotegerin Gene Are Associated With Osteoporotic Fractures
Langdahl, B. L., Carstens, M., Stenkjær, L. L., & Eriksen, E. F. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.7.1245 · Cited by 190
Khosla, S., Atkinson, E. J., Dunstan, C. R., & O’Fallon, W. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8397 · Cited by 191
Demographic variations in the rising incidence of esophageal adenocarcinoma in white males
Bollschweiler, E., Wolfgarten, E., Gutschow, C. A., & H�lscher, A. H. (2001) · Cancer · doi:10.1002/1097-0142(20010801)92:3 · Cited by 452
The proliferation and phenotypic expression of human osteoblasts on tantalum metal
Findlay, D. M., Welldon, K. J., Atkins, G. J., Howie, D. W., Zannettino, A. C. W., & Bobyn, D. J. (2003) · Biomaterials · doi:10.1016/j.biomaterials.2003.09.005 · Cited by 189
Osteoclasts are important for bone angiogenesis
Cackowski, F. C., Anderson, J. L., Patrene, K. D., Choksi, R. J., Shapiro, S. D., Windle, J. J., Blair, H. C., & Roodman, G. D. (2010) · Blood · doi:10.1182/blood-2009-08-237628 · Cited by 188
Morony, S., Capparelli, C., Lee, R., Shimamoto, G., Boone, T., Lacey, D. L., & Dunstan, C. R. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.9.1478 · Cited by 187
Serum levels of osteoprotegerin increase with age in a healthy adult population.
Kudlacek, S., Schneider, B., Woloszczuk, W., Pietschmann, P., & Willvonseder, R. (2003) · Bone · doi:10.1016/s8756-3282(03)00090-5 · Cited by 187
The RANK/RANKL/OPG triad in cancer-induced bone diseases
Dougall, W. C., & Chaisson, M. L. (2006) · Cancer and Metastasis Reviews · doi:10.1007/s10555-006-9021-3 · Cited by 189
Osteocyte regulation of bone mineral: a little give and take
Atkins, G. J., & Findlay, D. M. (2012) · Osteoporosis International · doi:10.1007/s00198-012-1915-z · Cited by 194
Crotti, T. N., Smith, M. D., Weedon, H., Ahern, M. J., Findlay, D. M., Kraan, M., Tak, P. P., & Haynes, D. R. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.12.1047 · Cited by 186
The osteoclastogenic molecules RANKL and RANK are associated with periprosthetic osteolysis
Haynes, D. R., Crotti, T. N., Potter, A. E., Loric, M., Atkins, G. J., Howie, D. W., & Findlay, D. M. (2001) · Journal of Bone and Joint Surgery - British Volume · doi:10.1302/0301-620x.83b6.10905 · Cited by 186
Changing RANKL/OPG mRNA expression in differentiating murine primary osteoblasts
Thomas, G. P., Baker, S., Eisman, J. A., & Gardiner, E. M. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700451 · Cited by 184
Evaluation of Pharmaceuticals With a Novel 50-Hour Animal Model of Bone Loss
Tomimori, Y., Mori, K., Koide, M., Nakamichi, Y., Ninomiya, T., Udagawa, N., & Yasuda, H. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090217 · Cited by 184
Self-citationRANKL/RANK/OPG system beyond bone remodeling: involvement in breast cancer and clinical perspectives
Infante, M., Fabi, A., Cognetti, F., Gorini, S., Caprio, M., & Fabbri, A. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-1001-2 · Cited by 180
Fujita, K.-I., & Janz, S. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-71 · Cited by 179
Mechanism of osteoclast mediated bone resorption—rationale for the design of new therapeutics
VAANANEN, K. (2005) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.12.018 · Cited by 176
Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice.
Cao, J., Venton, L., Sakata, T., & Halloran, B. P. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.2.270 · Cited by 173
Yamaguchi, M., & Fukasawa, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052388 · Cited by 175
Nagy, V., & Penninger, J. M. (2015) · Gerontology · doi:10.1159/000371845 · Cited by 175
RANKL, RANK, osteoprotegerin: key partners of osteoimmunology and vascular diseases
Baud’huin, M., Lamoureux, F., Duplomb, L., Rédiní, F., & Heymann, D. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7104-0 · Cited by 177
Kazama, J. J., Shigematsu, T., Yano, K., Tsuda, E., Miura, M., Iwasaki, Y., Kawaguchi, Y., Gejyo, F., Kurokawa, K., & Fukagawa, M. (2002) · American Journal of Kidney Diseases · doi:10.1053/ajkd.2002.31402 · Cited by 169
Self-citationKohli, S. S., & Kohli, V. S. (2011) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.83401 · Cited by 181
Hofbauer, L. C., & Heufelder, A. E. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.7.6702 · Cited by 178
Low-Dose Creatine Combined with Protein during Resistance Training in Older Men
CANDOW, D. G., LITTLE, J. P., CHILIBECK, P. D., ABEYSEKARA, S., ZELLO, G. A., KAZACHKOV, M., CORNISH, S. M., & YU, P. H. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318176b310 · Cited by 168
Osteotropic cancers: From primary tumor to bone
Buijs, J. T., & van der Pluijm, G. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.044 · Cited by 175
Recent advances in osteoclast biology and pathological bone resorption.
Blair, H. C., & Athanasou, N. A. (2004) · PubMed · doi:10.14670/hh-19.189 · Cited by 169
Disruption of BMP Signaling in Osteoblasts Through Type IA Receptor (BMPRIA) Increases Bone Mass
Kamiya, N., Ye, L., Kobayashi, T., Lucas, D. J., Mochida, Y., Yamauchi, M., Kronenberg, H. M., Feng, J. Q., & Mishina, Y. M. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080809 · Cited by 167
Zannettino, A. C. W., Holding, C. A., Diamond, P., Atkins, G. J., Kostakis, P., Farrugia, A., Gamble, J. R., To, L. B., Findlay, D. M., & Haynes, D. R. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20354 · Cited by 169
Bone metastatic LNCaP‐derivative C4‐2B prostate cancer cell line mineralizes in vitro
Lin, D., Tarnowski, C. P., Zhang, J., Dai, J., Rohn, E., Patel, A. H., Morris, M. D., & Keller, E. T. (2001) · The Prostate · doi:10.1002/pros.1065 · Cited by 163
Enomoto, H., Shiojiri, S., Hoshi, K., Furuichi, T., Fukuyama, R., Yoshida, C. A., Kanatani, N., Nakamura, R. M., Mizuno, A., Zanma, A., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302457200 · Cited by 163
Self-citationXu, J., Tan, J., Huang, L., Gao, X., Laird, R., Liu, D., Wysocki, S. J., & Zheng, M. (2000) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2000.15.11.2178 · Cited by 160
Pan, B.-Q., Farrugia, A. N., To, L. B., Findlay, D. M., Green, J., Lynch, K., & Zannettino, A. C. W. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2004.19.1.147 · Cited by 157
Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget’s disease of bone.
Menaa, C., Reddy, S. V., Kurihara, N., Maeda, H., Anderson, D., Cundy, T., Cornish, J., Singer, F. R., Bruder, J. M., & Roodman, G. D. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9133 · Cited by 154
Osteoprotegerin: Multiple partners for multiple functions
Baud’huin, M., Duplomb, L., Teletchea, S., Lamoureux, F., Ruiz-Velasco, C., Maillasson, M., Redini, F., Heymann, M.-F., & Heymann, D. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.06.001 · Cited by 153
Promoter structure of mouse RANKL/TRANCE/OPGL/ODF gene
Kitazawa, R., Kitazawa, S., & Maeda, S. (1999) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(99)00032-9 · Cited by 153
Kong, Y., Boyle, W. J., & Penninger, J. M. (1999) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1999.00815.x · Cited by 153
Pettit, A. R., Walsh, N. C., Manning, C., Goldring, S. R., & Gravallese, E. M. (2006) · Rheumatology · doi:10.1093/rheumatology/kel045 · Cited by 151
Mackie, P. S., Fisher, J. L., Zhou, H., & Choong, P. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2000.1679 · Cited by 149
PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways
Zhang, J., Fu, M., Myles, D., Zhu, X., Du, J., Cao, X., & Chen, Y. E. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02872-7 · Cited by 150
Candow, D. G., Forbes, S. C., Chilibeck, P. D., Cornish, S. M., Antonio, J., & Kreider, R. B. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8040488 · Cited by 149
Lerner, U. H. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500202 · Cited by 147
Osteoclast-Derived Coupling Factors in Bone Remodeling
Henriksen, K., Karsdal, M. A., & Martin, T. J. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9741-7 · Cited by 146
Mizuno, A., Kanno, T., HOSHI, M., Shibata, O., Yano, K., Fujise, N., Kinosaki, M., Yamaguchi, K., Tsuda, E., Murakami, A., et al. (2002) · Journal of Bone and Mineral Metabolism · doi:10.1007/s007740200049 · Cited by 148
Self-citationDifferentiation and functions of osteoclasts and odontoclasts in mineralized tissue resorption
Sasaki, T. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10370 · Cited by 149
Root resorption and the OPG/RANKL/RANK system: a mini review
Tyrovola, J. B., Spyropoulos, M. N., Makou, M., & Perrea, D. N. (2008) · Journal of Oral Science · doi:10.2334/josnusd.50.367 · Cited by 143
Wada, N., Maeda, H., Yoshimine, Y., & Akamine, A. (2004) · Bone · doi:10.1016/j.bone.2004.04.023 · Cited by 145
Kondo, H., Guo, J., & Bringhurst, F. R. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.9.1667 · Cited by 143
Mechanisms of Disease: roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis
Blair, J. M., Zhou, H., Seibel, M. J., & Dunstan, C. R. (2006) · Nature Clinical Practice Oncology · doi:10.1038/ncponc0381 · Cited by 142
Hanada, R., Hanada, T., Sigl, V., Schramek, D., & Penninger, J. M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0749-z · Cited by 147
Managing bone metastases and reducing skeletal related events in prostate cancer
Gartrell, B. A., & Fred Saad, C. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.70 · Cited by 141
Takeuchi, T., Tsuboi, T., Arai, M., & Togari, A. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00591-8 · Cited by 139
OsteoimmunologyPreprint
Okamoto, K., & Takayanagi, H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031245 · Cited by 146
The pathophysiology of cancer-induced bone pain: current understanding
Urch, C. (2004) · Palliative Medicine · doi:10.1191/0269216304pm887ra · Cited by 138
Kacena, M. A., Shivdasani, R. A., Wilson, K. M., Xi, Y., Troiano, N. W., Nazarian, A., Gundberg, C. M., Bouxsein, M., Lorenzo, J. A., & Horowitz, M. C. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.0301254 · Cited by 139
Aoki, K., Saito, H., Itzstein, C., Ishiguro, M., Shibata, T., Blanqué, R., Mian, A. H., Takahashi, M., Suzuki, Y., Yoshimatsu, M., et al. (2006) · Journal of Clinical Investigation · doi:10.1172/jci22513 · Cited by 136
Lu, H. ‐., Chen, Y., Chang, H., Li, C., & Kuo, M. Y. (2006) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2006.00883.x · Cited by 137
(2005) · PubMed · Cited by 135
Chen, L., Wei, X., Evans, B. A. J., Jiang, W. G., & Aeschlimann, D. P. (2008) · European Journal of Immunology · doi:10.1002/eji.200838192 · Cited by 135
OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice
Shimamura, M., Nakagami, H., Osako, M. K., Kurinami, H., Koriyama, H., Zhengda, P., Tomioka, H., Tenma, A., Wakayama, K., & Morishita, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1400544111 · Cited by 134
Osteoclast migration, differentiation and function: novel therapeutic targets for rheumatic diseases
Kikuta, J., & Ishii, M. (2012) · Rheumatology · doi:10.1093/rheumatology/kes259 · Cited by 139
Creatine supplementation in the aging population: effects on skeletal muscle, bone and brain
Gualano, B., Rawson, E. S., Candow, D. G., & Chilibeck, P. D. (2016) · Amino Acids · doi:10.1007/s00726-016-2239-7 · Cited by 133
Dempster, D. W., Lambing, C. L., Kostenuik, P. J., & Grauer, A. (2012) · Clinical Therapeutics · doi:10.1016/j.clinthera.2012.02.002 · Cited by 138
Effects of human aging on periodontal tissues
Huttner, E. A., Machado, D. C., de Oliveira, R. B., Antunes, A. G. F., & Hebling, E. (2009) · Special Care in Dentistry · doi:10.1111/j.1754-4505.2009.00082.x · Cited by 133
Metadata
- Authors
- Yasuda, H., Shima, N., Nakagawa, N., Mochizuki, S.-I., Yano, K., Fujise, N., Sato, Y., Goto, M., Yamaguchi, K., Kuriyama, M., Kanno, T., Murakami, A., Tsuda, E., Morinaga, T., & Higashio, K.
- Affiliations
- Megmilk Snow Brand (Japan) (JP)
- Corresponding author
- Higashio, Kanji
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 1998-03
- Volume
- 139
- Issue
- 3
- Pages
- 1329-1337
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2167886526
- Cited by
- 1,201
- References
- 33
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 21 · 2023: 15 · 2022: 21 · 2021: 21 · 2020: 29 · 2019: 36 · 2018: 22 · 2017: 38 · 2016: 22 · 2015: 28 · 2014: 36 · 2013: 54 · 2012: 35
- FWCI
- 24.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoprotegerin, osteoclastogenesis inhibition, TNF receptor superfamily, bone remodeling, bone mineral density, stromal cells, osteoblasts, cell-to-cell signaling, 1,25-dihydroxyvitamin D3, bone resorption, gene cloning
- MeSH terms
- Amino Acid Sequence, Animals, Cells, Cultured, Cloning, Molecular, Glycoproteins, Humans, Male, Molecular Sequence Data, Osteoclasts, Recombinant Proteins, Bone Density, Bone Remodeling, Rats, Sprague-Dawley, Receptors, Tumor Necrosis Factor, Receptors, Cytoplasmic and Nuclear, Mice, Rats, Osteoprotegerin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review