The DOI matches its OpenAlex record; 7 of the 7 references it cites were found in a registry or an index.
Differential Expression of Peroxisome Proliferator-Activated Receptor- , - , and - during Rat Embryonic Development
Abstract
The expression patterns of the three different peroxisome proliferator-activated receptor (PPAR) isotypes have been determined during rat embryonic development by in situ hybridization. The expression of PPARalpha starts late in development, with increasing levels in organs such as liver, kidney, intestine, and pancreas, in which it will also be present later in adulthood to regulate its specific target genes. PPARalpha is also transiently expressed in the embryonic epidermis and central nervous system. PPARgamma presents a very restricted pattern of expression, being strongly expressed in brown adipose tissue, in which differentiation it has been shown to participate. Like PPARalpha, it is also expressed transiently in the central nervous system. Interestingly, PPARalpha, -beta and -gamma are coexpressed at high levels in brown adipose tissue. Finally, the high and ubiquitous expression of PPARbeta suggests some fundamental role(s) that this receptor might play throughout development.
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Citations
Cites
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217
Self-citationKliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164
Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116
Thermogenic mechanisms in brown fat.
Nicholls, D. G., & Locke, R. M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.1 · Cited by 1,602 · cited 1×
“This heat dissipation is made possible by the expression of a specific BAT protein, UCP, which uncouples the fatty acid oxidation from the synthesis of ATP (35, 36).”
BackgroundThe PPARα–leukotriene B4 pathway to inflammation control
Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., & Wahli, W. (1996) · Nature · doi:10.1038/384039a0 · Cited by 1,345
Self-citationDevelopment of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · cited 1×
“Transgenic mice lacking BAT develop obesity (37), providing evidence for FIG.”
Background
Cited by
The mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659
Varga, T., Czimmerer, Z., & Nagy, L. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.02.014 · Cited by 933
Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., & Wahli, W. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2005.12.002 · Cited by 786
Self-citationWolfrum, C., Borrmann, C. M., Börchers, T., & Spener, F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.051619898 · Cited by 503
PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice
Tran, M., Tam, D., Bardia, A., Bhasin, M., Rowe, G. C., Kher, A., Zsengeller, Z. K., Akhavan-Sharif, M. R., Khankin, E. V., Saintgeniez, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58662 · Cited by 499
Metadata
- Authors
- Braissant, O., & Wahli, W.
- Venue
- Endocrinology
- Publisher
- Oxford University Press
- Published
- 1998-06-01
- Volume
- 139
- Issue
- 6
- Pages
- 2748-2754
- ISSN
- 0013-7227 (ISSN-L)
- OpenAlex
- W2184835492
- Cited by
- 454
- References
- 7
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Differential Expression of Peroxisome Proliferator-Activated Receptor- , - , and - during Rat Embryonic Development. https://app.cochat.ai/papers/10.1210/en.139.6.2748
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- Braissant, O., & Wahli, W. (1998). Differential Expression of Peroxisome Proliferator-Activated Receptor- , - , and - during Rat Embryonic Development. Endocrinology. https://doi.org/10.1210/en.139.6.2748
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
