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Cited by 111Sexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesNeuroendocrine regulation and behavior

Potential Role of Maternal Progesterone in the Sexual Differentiation of the Brain

Wagner, Christine K., Nakayama, Ann Y., De Vries, Geert J.·1998·Endocrinology
DOI 10.1210/endo.139.8.6223
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Abstract

In rats, fetal testosterone directs sexual differentiation of the brain. However, fetuses are also exposed to maternal progesterone. Here we report that progestin receptor immunoreactivity in the medial preoptic nucleus (MPN) of fetal and neonatal rats is high in males but virtually absent in females. The MPN is one of the most sexually dimorphic structures in the rat brain and mediates several sexually differentiated behaviors. This suggests that progesterone may play a previously overlooked role in the development of sex differences in the brain and behavior. Henceforth, a novel function of the mother in the sexual differentiation of the CNS must be considered.

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  • Males express more PRs than females within several hypothalamic regions on postnatal day 1 but not PN10.

    “express more PRs than females within several hypothalamic regions on postnatal day (PN)1 but not PN10 [8, 9].”

    From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [9]

    The Results (p. 2) report significantly more PR-immunoreactive cells in males than females on the day of birth, but establish that difference only for the medial preoptic nucleus. The paper lists other regions containing PR-immunoreactive cells without reporting the same sex difference in them, and it does not report a PN10 comparison. (LLM, conf=0.88)

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Cites

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Research works printed but not linked: 3

  1. [13]13. Altman, J Bayer, SA 1995 Atlas of Prenatal Rat Brain Development. CRC Press, Boca Raton 485.
  2. [14]14. Sachs, BD Meisel, RL 1994 The physiology of male sexual behavior. In: Knobil, E Neill, J (eds) The Physiology of Reproduction. Raven Press, New York, 3-75
  3. [15]15. Numan, M 1994 Maternal behavior. In: The Physiology of Reproduction. Knobil, E Neill, J (eds) The Physiology of Reproduction. Raven Press, New York, 223-283

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Authors
Wagner, C. K., Nakayama, A. Y., & De Vries, G. J.
Affiliations
University of Massachusetts Amherst (US)
Corresponding author
Wagner, Christine K.
ORCID
Wagner, Christine K.
Venue
Endocrinology
Publisher
The Endocrine Society
Published
1998-08
Volume
139
Issue
8
Pages
3658-3661
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.139.8.6223
OpenAlex
W2083242486
Cited by
111
References
0
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 8 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 5
FWCI
2.45
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders
  • National Institutes of Health (1r03mh057237-01)
  • National Institute of Mental Health (MH55562, MH57237, R01MH047538, MH47538)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
maternal progesterone, sexual differentiation of the brain, progestin receptor, medial preoptic nucleus, fetal testosterone, sex differences in brain, fetal brain development, neonatal rats
MeSH terms
Animals, Animals, Newborn, Brain, Female, Gestational Age, Immunohistochemistry, Male, Preoptic Area, Progesterone, Receptors, Progesterone, Sex Characteristics, Sex Differentiation, Rats, Sprague-Dawley, Rats

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