Cited by 146Steroid Chemistry and BiochemistryAdrenal Hormones and DisordersSexual Differentiation and Disorders

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Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in the rat Purkinje neuron during neonatal life

Ukena, Kazuyoshi, Kohchi, Chie, Tsutsui, Kazuyoshi·1999·Endocrinology

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Abstract

Recently, we demonstrated that cytochrome P450 side-chain cleavage enzyme (P450scc) occurs in the rat cerebellar Purkinje cell after differentiation and remains during neonatal development and into adulthood. 3Beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase (3betaHSD) is also an essential enzyme for progesterone biosynthesis not only in peripheral steroidogenic glands but also in the nervous system. In the present study, therefore, the expression of 3betaHSD in the rat cerebellum was investigated during neonatal development and in the adult. RT-PCR analysis showed that the expression of 3betaHSD messenger RNA (mRNA) in the cerebellum was higher at 7-14 days of age than at other times. Biochemical studies together with HPLC analysis revealed that cerebellar slices at 10 days of age converted pregnenolone to progesterone, suggesting enzymatic activity of 3betaHSD. This conversion was significantly reduced by trilostane, a specific inhibitor of 3betaHSD. A specific RIA indicated that progesterone concentrations in the cerebellum were higher at 3 and 10 days of age than at 60 days of age. The progesterone level in the cerebellum was significantly higher than that in plasma at 10 days of age. In contrast, the concentrations in both cerebellum and plasma at 3 and 60 days of age were similar. In the present study, the site of 3betaHSD mRNA expression in the cerebellum was further examined in neonatal and adult rats using in situ hybridization. The cerebellar expression of 3betaHSD mRNA was obscure at 3 days of age, whereas intense expression occurred in Purkinje cells and external granule cells throughout the cerebellum at 10 days of age. 3BetaHSD mRNA was also expressed in Purkinje cells and granule cells at 60 days of age, but a restricted expression was observed along the cerebellar meninges. These results suggest that the steroidogenic enzyme 3betaHSD as well as P450scc are expressed at least in the cerebellar Purkinje cell. The expression of 3betaHSD, however, may increase for a limited period around 10 days of age, unlike P450scc.

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Authors: Ukena, K., Kohchi, C., & Tsutsui, K.
Affiliations: Hiroshima University (JP)
Corresponding author: Tsutsui, Kazuyoshi
ORCID: Ukena, Kazuyoshi
Tsutsui, Kazuyoshi
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 1999-02-01
Volume: 140
Issue: 2
Pages: 805-813
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.140.2.6516
OpenAlex: W2046524470
Semantic Scholar: 3e1088688415429d5478a3e54657be8a7c93ab31
Cited by: 141
References: 61
Citations by year: 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 3 · 2016: 8 · 2015: 1 · 2014: 6 · 2013: 3 · 2012: 4
FWCI: 2.88
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: University of Central Lancashire
Japan Society for the Promotion of Science
Topics: Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase, Purkinje cells, neonatal development, progesterone biosynthesis, pregnenolone, trilostane, mRNA expression
MeSH terms: Aging, Animals, Animals, Newborn, Cerebellum, Male, Progesterone, Purkinje Cells, Radioimmunoassay, Rats, Inbred F344, RNA, Messenger, 17-Hydroxysteroid Dehydrogenases, In Situ Hybridization, Rats

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Expression and activity of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in the rat Purkinje neuron during neonatal life

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