The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Maternal Undernutrition during Late Gestation Induces Fetal Overexposure to Glucocorticoids and Intrauterine Growth Retardation, and Disturbs the Hypothalamo-Pituitary Adrenal Axis in the Newborn Rat1
Abstract
As fetal overexposure to glucocorticoids has been postulated to induce intrauterine growth retardation (IUGR) in humans, we investigated the effects of maternal 50% food restriction (FR50) in rats during the last week of gestation on the hypothalamo-pituitary adrenal (HPA) axis activity in both mothers and their fetuses. In mothers, FR50 increased both the plasma corticosterone (B) level from embryonic days 19-21 and the relative adrenal weight at term. FR50 decreased at term both the maternal plasma corticosteroid-binding globulin level and placental 11beta-hydroxysteroid dehydrogenase type 2 expression. In newborns, maternal FR50 reduced body and adrenal weights, glucocorticoid and mineralocorticoid receptor expressions in the hippocampus, corticoliberin expression in the hypothalamic paraventricular nucleus, and plasma ACTH. In FR50 newborns, the plasma B level was increased at birth and decreased 2 h later. When maternal circulating B was maintained at the basal level by adrenalectomy and B supply, FR50 induced IUGR in pups and decreased placental 11beta- hydroxysteroid dehydrogenase type 2 expression at term, but did not disturb the offspring's HPA axis. These results suggest that maternal undernutrition during late gestation induces both IUGR and an overexposure of fetuses to maternal B, which disturb the development of the HPA axis.
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Cited by
Developmental Origins of the Metabolic Syndrome: Prediction, Plasticity, and Programming
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11β-hydroxysteroid dehydrogenases: Intracellular gate-keepers of tissue glucocorticoid action
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Prenatal glucocorticoids and long-term programming
Seckl (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.151u049 · Cited by 825
Prenatal stress, glucocorticoids and the programming of adult disease
Cottrell, E. C. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.019.2009 · Cited by 640
The developmental origins of adult disease (Barker) hypothesis
DE BOO, H. A., & HARDING, J. E. (2006) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/j.1479-828x.2006.00506.x · Cited by 630
Metadata
- Authors
- Lesage, J., Blondeau, B., Grino, M., Bréant, B., & Dupouy, J. P.
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2001-05
- Volume
- 142
- Issue
- 5
- Pages
- 1692-1702
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2041277193
- Cited by
- 379
- References
- 47
- FWCI
- 14.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lesage, J., Blondeau, B., Grino, M., Bréant, B., & Dupouy, J. P. (2001). Maternal Undernutrition during Late Gestation Induces Fetal Overexposure to Glucocorticoids and Intrauterine Growth Retardation, and Disturbs the Hypothalamo-Pituitary Adrenal Axis in the Newborn Rat1. Endocrinology. https://doi.org/10.1210/endo.142.5.8139
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