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Cited by 94Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentThyroid and Parathyroid Surgery

Expression and regulation of type II iodothyronine deiodinase in human thyroid gland

Murakami, Masami, Araki, Osamu, Hosoi, Yasuhiro, Kamiya, Yuji, Morimura, Tadashi, Ogiwara, Takayuki, Mizuma, Haruo, Mori, Masatomo·2001·Endocrinology
DOI 10.1210/endo.142.7.8280
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Abstract

We have studied the expression of type II iodothyronine deiodinase (DII) in human thyroid tumors and cultured human thyroid cells to elucidate the mechanisms involved in the regulation of DII expression in human thyroid gland. Three cases with hyperfunctioning thyroid adenoma, including a case that showed an activating mutation of G(s)alpha with a constitutive activation of cAMP production in cultured cells, and six cases with papillary thyroid carcinoma were analyzed in the present study. Free T(3) was increased, whereas free T(4) was within the normal range in all patients with hyperfunctioning thyroid adenoma. Thyroid tumor tissue and surrounding nontumor tissue were obtained at the time of surgery, and DII expression was compared between tumor tissue and nontumor tissue in each case. Northern analysis demonstrated the presence of DII messenger RNA (mRNA) approximately 7.5 kb in size in all of the tumor and nontumor tissues. DII mRNA and DII activity in hyperfunctioning thyroid adenoma were significantly increased compared with those in nontumor tissue in each case. In contrast, DII mRNA and DII activity in papillary thyroid carcinoma were decreased compared with those in nontumor tissue in each case. DII mRNA and DII activity in cultured human thyroid cells were significantly stimulated by TSH in a dose-dependent manner. The promoter activity of the human DII gene including the complete cAMP response element, transfected to cultured human thyroid cells, was stimulated by…

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  • TSHR-mediated upregulation of DIO2 contributes significantly to the relative increase in intrathyroidal T4-to-T3 conversion and thus T3 production and higher circulating T3/T4 ratio in patients with Graves' disease and toxic adenomas.

    “TSHR-mediated upregulation of DIO2 contributes significantly to the relative increase in intrathyroidal T4-to-T3 conversion and thus T3 production and higher circulating T3/T4 ratio in patients with Graves’ disease and toxic adenomas (182, 183).”

    From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [183]

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Authors
Murakami, M., Araki, O., Hosoi, Y., Kamiya, Y., Morimura, T., Ogiwara, T., Mizuma, H., & Mori, M.
Affiliations
Gunma University (JP)
Corresponding author
Murakami, Masami
ORCID
Venue
Endocrinology
Publisher
The Endocrine Society
Published
2001-07-01
Volume
142
Issue
7
Pages
2961-2967
ISSN
  • 0013-7227 (ISSN-L)
  • 1945-7170
DOI
10.1210/endo.142.7.8280
OpenAlex
W1965494580
Cited by
94
References
1
Citations by year
2026: 1 · 2025: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 2 · 2015: 3 · 2013: 4 · 2012: 4
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
American Thyroid Association
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
type 2 deiodinase, thyroid gland, papillary thyroid carcinoma, TSH regulation, cAMP response element, Gs protein, TSH receptor, transcriptional regulation, free triiodothyronine, Graves' disease
MeSH terms
Adenoma, Cyclic AMP, Adult, Aged, Aged, 80 and over, Carcinoma, Papillary, Cells, Cultured, Female, Humans, Iodide Peroxidase, Isoenzymes, Middle Aged, Molecular Sequence Data, Promoter Regions, Genetic, RNA, Messenger, Thyroid Gland, Thyroid Hormones, Thyroid Neoplasms, Thyrotropin, Response Elements

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