Cited by 395Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesAdipokines, Inflammation, and Metabolic Diseases

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Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

Grill, Harvey J., Schwartz, Michael W., Kaplan, Joel M., Foxhall, James S., Breininger, John, Baskin, Denis G.·2002·Endocrinology

DOI 10.1210/endo.143.1.8589

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Abstract

Three experiments were performed to investigate the hypothesis that leptin action within the caudal brain stem (CBS) contributes to its intake inhibitory effects. The first experiment evaluated the anatomical distribution of leptin receptor mRNA in rat CBS using a sensitive fluorescence in situ hybridization method with a riboprobe specific for the long form of the leptin receptor (Ob-Rb). An Ob-Rb mRNA hybridization signal was detected in neurons of several CBS nuclei involved in the control of food intake, including the dorsal vagal complex and parabrachial nucleus. A strong hybridization signal was also obtained from neuronal cell bodies of a number of other structures including the hypoglossal, trigeminal, lateral reticular, and cochlear nuclei; locus ceruleus; and inferior olive. The anatomical profile revealed by fluorescence in situ hybridization was in good agreement with immunocytochemical analysis with an antibody specific to Ob-Rb. In a second experiment, exploring the relevance of CBS Ob-Rb to feeding behavior, rats were given a fourth intracerebroventricular (i.c.v.) injection of leptin (0.1, 0.83, or 5.0μ g; n = 9–11/group) or vehicle 30 min before lights-out on three consecutive days The two higher doses reduced food intake significantly at 2, 4, and 24 h after injection and caused significant reductions of body weight. The dose-response profiles for fourth i.c.v. administration were indistinguishable from those obtained from separate groups of rats that received leptin via a lateral i.c.v. cannula. In the last experiment, a ventricle-subthreshold dose of leptin (0.1 μg) microinjected unilaterally into the dorsal vagal complex suppressed food intake at 2, 4, and 24 h. The results indicate that the CBS contains neurons that are potentially direct targets for the action of leptin in the control of energy homeostasis.

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Leptin in Dairy Cows: Metabolic Adaptation, Reproductive Function, and Health Applications
Martínez-Barbitta, M., Biagini, A., Costanzi, E., Guelfi, G., Maranesi, M., García‐Díez, J., Saraiva, C. M. T., Karama, M., El-Ashram, S. A., Al-Olayan, E. M., et al. (2026) · Life · doi:10.3390/life16060987
“Leptin, by signalling adequate energy reserves, is believed to counterbalance this inhibition and favour the resumption or maintenance of pulsatile GnRH and LH secretion, particularly in nutritionally challenged animals [114].”

Authors: Grill, H. J., Schwartz, M. W., Kaplan, J. M., Foxhall, J. S., Breininger, J., & Baskin, D. G.
Affiliations: University of Pennsylvania (US)
University of Washington (US)
Corresponding author: Grill, Harvey J.
ORCID: Grill, Harvey J.
Schwartz, Michael W.
Baskin, Denis G.
Venue: Endocrinology
Publisher: The Endocrine Society
Published: 2002-01-01
Volume: 143
Issue: 1
Pages: 239-246
ISSN: 0013-7227 (ISSN-L)
1945-7170
DOI: 10.1210/endo.143.1.8589
OpenAlex: W1976978438
Cited by: 395
References: 51
Citations by year: 2026: 2 · 2025: 4 · 2024: 8 · 2023: 6 · 2022: 6 · 2021: 8 · 2020: 12 · 2019: 8 · 2018: 14 · 2017: 8 · 2016: 11 · 2015: 11 · 2014: 20 · 2013: 22 · 2012: 28
FWCI: 7.67
Type: journal article
Language: en
Open access: closed
Locations: Endocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
University of Pennsylvania
University of Washington (DK17047)
National Institutes of Health (2r01dk012829-36, DK21397)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 12829, R01DK042284, R01DK052989, DK-42284, DK-52989, DK-17047, DK 21397, P30DK017047)
National Institute of Neurological Disorders and Stroke (NS-32272)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Keywords: leptin, caudal brainstem, food intake regulation, dorsal vagal complex, parabrachial nucleus, energy homeostasis, weight loss, hypothalamic-pituitary-thyroid axis
MeSH terms: Animals, Brain Stem, Carrier Proteins, Eating, Injections, Intraventricular, Male, Receptors, Cell Surface, Tissue Distribution, Vagus Nerve, Rats, Wistar, Protein Isoforms, Fourth Ventricle, Lateral Ventricles, Leptin, Rats, Receptors, Leptin

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Evidence That the Caudal Brainstem Is a Target for the Inhibitory Effect of Leptin on Food Intake

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