Are the effects of T3 on resting metabolic rate in euthyroid rats entirely caused by T3 itself?
Abstract
Because we previously reported that T3 and 3,5-diiodo-L-thyronine (3,5-T2) both increase resting metabolic rate (RMR), 3,5-T2 could be another thyroidal regulator of energy metabolism. This effect of 3,5-T2 is evident in rats made hypothyroid by propylthiouracil and iopanoic acid, not in normal euthyroid (N) rats. Possibly, under euthyroid conditions, active 3,5-T2 may need to be formed intracellularly from a precursor such as T3. We tested this hypothesis by giving a single injection of T3 to N rats and comparing the time course of the variations in RMR with those of the changes in the serum and hepatic levels of 3,5-T2. Acute injection had an evident effect on RMR, 25 h earlier, in N rats than in rats made hypothyroid by propylthiouracil and iopanoic acid, maximal values (+40%) being reached in the former at 24-26 h. In N rats, the simultaneous injection of actinomycin D with the T3 inhibited the late part of the effect (after 24 h) more strongly than the early part (14-24 h). In serum and liver, 3,5-T2 levels were increased significantly at 12-24 h after T3 injection into N rats, a time at which RMR was rising rapidly to peak. These results seem to indicate that when T3 is injected into N animals, not all the effects on RMR are attributable to T3 itself, the early effect presumably being largely because of its in vivo deiodination to 3,5-T2. Because the effects of T3 and 3,5-T2 are additive, in N rats, the two iodothyronines probably cooperate in vivo to determine the tota…
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Reported serum concentrations for 3,3′-T2 covered a very narrow concentration range between 36 and 68 pM.
“Reported serum concentrations covered a very narrow concentration range between 36 and 68 pM for 3,3′-T2 (see Table 1) (23–29, 32–34).”
From 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action (2020) · cites this paper as [28]
No information had been published on 3,5-T2 concentrations reached in the circulation or in target tissues like liver in those studies.
“Unfortunately, no information had been published on 3,5-T2 concentrations reached in the circulation or in those target tissues like liver, where beneficial effects such as antisteatotic activity and increased lipid metabolism were reported (15, 17, 28, 89, 90).”
From 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action (2020) · cites this paper as [28]
3,5-T2 increases the resting metabolic rate and oxygen consumption in rats.
“In general, 3,5-diiodothyronine (3,5-T2) increases the resting metabolic rate and oxygen consumption, exerting short-term beneficial metabolic effects on rats subjected to a high-fat diet.”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Moreno et al. 2002
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- Authors
- Moreno, M., Lombardi, A., Beneduce, L., Silvestri, E., Pinna, G., Goglia, F., & Lanni, A.
- Affiliations
- Dipartimento di Scienze Biologiche ed Ambientali (M.M., E.S., F.G.), Università degli Studi del Sannio, 82100 Benevento, Italy
- University of Naples Federico II (IT)
- University of Sannio (IT)
- Freie Universität Berlin (DE)
- University of Campania "Luigi Vanvitelli" (IT)
- Corresponding author
- Lanni, Antonia
- Venue
- Endocrinology
- Publisher
- The Endocrine Society
- Published
- 2002-02-01
- Volume
- 143
- Issue
- 2
- Pages
- 504-510
- ISSN
- 0013-7227 (ISSN-L)
- 1945-7170
- OpenAlex
- W2159855344
- Cited by
- 87
- References
- 0
- Citations by year
- 2023: 8 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 5 · 2012: 3
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- triiodothyronine, 3,5-diiodo-L-thyronine, resting metabolic rate, energy metabolism, thyroid hormone deiodination, actinomycin D, propylthiouracil, iopanoic acid, hypothyroidism, serum thyroid hormones
- MeSH terms
- Animals, Basal Metabolism, Dactinomycin, Diiodothyronines, Enzyme Inhibitors, Hypothyroidism, Iodide Peroxidase, Iopanoic Acid, Liver, Male, Propylthiouracil, Protein Synthesis Inhibitors, Radioimmunoassay, Antithyroid Agents, Thyroid Gland, Triiodothyronine, Rats, Wistar, Rats
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