The DOI matches its Crossref record; 359 of the 359 references it cites were found in a registry or an index.
Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome
Open accessAbstract
More than 1 out of 10 women worldwide are diagnosed with polycystic ovary syndrome (PCOS), the leading cause of female reproductive and metabolic dysfunction. Despite its high prevalence, PCOS and its accompanying morbidities are likely underdiagnosed, averaging > 2 years and 3 physicians before women are diagnosed. Although it has been intensively researched, the underlying cause(s) of PCOS have yet to be defined. In order to understand PCOS pathophysiology, its developmental origins, and how to predict and prevent PCOS onset, there is an urgent need for safe and effective markers and treatments. In this review, we detail which animal models are more suitable for contributing to our understanding of the etiology and pathophysiology of PCOS. We summarize and highlight advantages and limitations of hormonal or genetic manipulation of animal models, as well as of naturally occurring PCOS-like females.
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Cites
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Cited by
Joham, A. E., Norman, R. J., Stener-Victorin, E., Legro, R. S., Franks, S., Moran, L. J., Boyle, J., & Teede, H. J. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00163-2 · Cited by 838
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Background
Metadata
- Authors
- Stener-Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2020-04-20
- Volume
- 41
- Issue
- 4
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W3016682625
- Cited by
- 348
- References
- 359
- FWCI
- 32.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- Funders
- Swedish Medical Research Council (2018-02435)
- Novo Nordisk Foundation (NNF19OC0056647)
- Stockholm County Council and Karolinska Institutet
- National Institutes of Health (HD041098, HD044232, P50HD071836, HD044405, HD028934, OD011106, DK121559)
- European Research Council (ERC-2016-CoG, 725149/REPRODAMH)
- National Health and Medical Research Council (APP1022648, APP1158540)
- Health Research Council of New Zealand (18-671)
- Royal Society Marsden Fund (17-64)
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- The paper
- Stener-Victorin, E., Padmanabhan, V., Walters, K. A., Campbell, R. E., Benrick, A., Giacobini, P., Dumesic, D. A., & Abbott, D. H. (2020). Animal Models to Understand the Etiology and Pathophysiology of Polycystic Ovary Syndrome. Endocrine Reviews. https://doi.org/10.1210/endrev/bnaa010
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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