The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Selenium, the Thyroid, and the Endocrine System
Abstract
Recent identification of new selenocysteine-containing proteins has revealed relationships between the two trace elements selenium (Se) and iodine and the hormone network. Several selenoproteins participate in the protection of thyrocytes from damage by H(2)O(2) produced for thyroid hormone biosynthesis. Iodothyronine deiodinases are selenoproteins contributing to systemic or local thyroid hormone homeostasis. The Se content in endocrine tissues (thyroid, adrenals, pituitary, testes, ovary) is higher than in many other organs. Nutritional Se depletion results in retention, whereas Se repletion is followed by a rapid accumulation of Se in endocrine tissues, reproductive organs, and the brain. Selenoproteins such as thioredoxin reductases constitute the link between the Se metabolism and the regulation of transcription by redox sensitive ligand-modulated nuclear hormone receptors. Hormones and growth factors regulate the expression of selenoproteins and, conversely, Se supply modulates hormone actions. Selenoproteins are involved in bone metabolism as well as functions of the endocrine pancreas and adrenal glands. Furthermore, spermatogenesis depends on adequate Se supply, whereas Se excess may impair ovarian function. Comparative analysis of the genomes of several life forms reveals that higher mammals contain a limited number of identical genes encoding newly detected selenocysteine-containing proteins.
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Cites
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Cited by
Selenium in human health and disease
Fairweather-Tait, S. J., Bao, Y., Broadley, M. R., Collings, R., Ford, D., Hesketh, J. E., & Hurst, R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3275 · Cited by 1,330
Deiodinases: implications of the local control of thyroid hormone action
Bianco, A. C., & Kim, B. W. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29812 · Cited by 845
Regulation of Selenium Metabolism and Transport
Burk, R. F., & Hill, K. E. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034250 · Cited by 658
Selenium in reproductive health
Mistry, H. D., Broughton Pipkin, F., Redman, C. W. G., & Poston, L. (2012) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2011.07.034 · Cited by 329
Stress Biomarkers in Biological Fluids and Their Point-of-Use Detection
Steckl, A. J., & Ray, P. (2018) · ACS Sensors · doi:10.1021/acssensors.8b00726 · Cited by 319
Metadata
- Authors
- Köhrle, J., Jakob, F., Contempré, B., & Dumont, J. E.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2005-09-20
- Volume
- 26
- Issue
- 7
- Pages
- 944-984
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2099736697
- Cited by
- 529
- References
- 33
- FWCI
- 20.44
- Type
- journal article
- Language
- en
- Open access
- closed
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