The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response
Abstract
Serine proteinases such as thrombin, mast cell tryptase, trypsin, or cathepsin G, for example, are highly active mediators with diverse biological activities. So far, proteinases have been considered to act primarily as degradative enzymes in the extracellular space. However, their biological actions in tissues and cells suggest important roles as a part of the body’s hormonal communication system during inflammation and immune response. These effects can be attributed to the activation of a new subfamily of G protein-coupled receptors, termed proteinase-activated receptors (PARs). Four members of the PAR family have been cloned so far. Thus, certain proteinases act as signaling molecules that specifically regulate cells by activating PARs. After stimulation, PARs couple to various G proteins and activate signal transduction pathways resulting in the rapid transcription of genes that are involved in inflammation. For example, PARs are widely expressed by cells involved in immune responses and inflammation, regulate endothelial-leukocyte interactions, and modulate the secretion of inflammatory mediators or neuropeptides. Together, the PAR family necessitates a paradigm shift in thinking about hormone action, to include proteinases as key modulators of biological function. Novel compounds that can modulate PAR function may be potent candidates for the treatment of inflammatory or immune diseases.
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Cites
The protease-activated receptor 2 regulates pigmentation via keratinocyte-melanocyte interactions
Seiberg, M., Paine, C., Sharlow, E., Andrade-Gordon, P., Costanzo, M., Eisinger, M., & Shapiro, S. S. (2000) · Experimental Cell Research · doi:10.1006/excr.1999.4692 · Cited by 238
Reed, D. E., Barajas‐Lopez, C., Cottrell, G., Velazquez‐Rocha, S., Dery, O., Grady, E. F., Bunnett, N. W., & Vanner, S. J. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2002.032011 · Cited by 192
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The protease-activated receptor-2 upregulates keratinocyte phagocytosis
Sharlow, E. R., Paine, C. S., Babiarz, L., Eisinger, M., Shapiro, S., & Seiberg, M. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.17.3093 · Cited by 150
Chin, A. C., Vergnolle, N., MacNaughton, W. K., Wallace, J. L., Hollenberg, M. D., & Buret, A. G. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831452100 · Cited by 149
Self-citationExpression of Protease-Activated Receptor 2 in Ulcerative Colitis
Kim, J.-A., Choi, S.-C., Yun, K.-J., Kim, D.-K., Han, M.-K., Seo, G.-S., Yeom, J.-J., Kim, T.-H., Nah, Y.-H., & Lee, Y.-M. (2003) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200307000-00002 · Cited by 96
Peripheral PAR-2 triggers thermal hyperalgesia and nociceptive responses in rats
Kawabata, A., Kawao, N., Kuroda, R., Tanaka, A., Itoh, H., & Nishikawa, H. (2001) · Neuroreport · doi:10.1097/00001756-200103260-00020 · Cited by 94
Scott, G., Leopardi, S., Parker, L., Babiarz, L., Seiberg, M., & Han, R. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12427.x · Cited by 87
Cited by
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
The testis in immune privilege
Fijak, M., & Meinhardt, A. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00438.x · Cited by 483
Differential release of mast cell mediators and the pathogenesis of inflammation
Theoharides, T. C., Kempuraj, D., Tagen, M., Conti, P., & Kalogeromitros, D. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00519.x · Cited by 425
Frontiers in pruritus research: scratching the brain for more effective itch therapy
Paus, R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28553 · Cited by 373
Heuberger, D. M., & Schuepbach, R. A. (2019) · Thrombosis Journal · doi:10.1186/s12959-019-0194-8 · Cited by 371
Metadata
- Authors
- Steinhoff, M., Buddenkotte, J., Shpacovitch, V., Rattenholl, A., Moormann, C., Vergnolle, N., Luger, T. A., & Hollenberg, M. D.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2004-10-12
- Volume
- 26
- Issue
- 1
- Pages
- 1-43
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2159231976
- Cited by
- 501
- References
- 8
- FWCI
- 17.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Steinhoff, M., Buddenkotte, J., Shpacovitch, V., Rattenholl, A., Moormann, C., Vergnolle, N., Luger, T. A., & Hollenberg, M. D. (2005). Proteinase-Activated Receptors: Transducers of Proteinase-Mediated Signaling in Inflammation and Immune Response. Endocrine Reviews. https://doi.org/10.1210/er.2003-0025
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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