Cited by 232Estrogen and related hormone effectsReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

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Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles

Vasudevan, Nandini, Pfaff, Donald W.·2007·Endocrine Reviews

DOI 10.1210/er.2005-0021

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Abstract

Hormonal ligands for the nuclear receptor superfamily have at least two interacting mechanisms of action: 1) classical transcriptional regulation of target genes (genomic mechanisms); and 2) nongenomic actions that are initiated at the cell membrane, which could impact transcription.Although transcriptional mechanisms are increasingly well understood, membrane-initiated actions of these ligands are incompletely understood.Historically, this has led to a considerable divergence of thought in the molecular endocrine field.We have attempted to uncover principles of hormone action that are relevant to membrane-initiated actions of estrogens.There is evidence that the membrane-limited actions of hormones, particularly estrogens, involve the rapid activation of kinases and the release of calcium.Membrane actions of estrogens, which activate these rapid signaling cascades, can also potentiate nuclear transcription.These signaling cascades may occur in parallel or in series but subsequently converge at the level of modification of transcriptionally relevant molecules such as nuclear receptors and/or coactivators.In addition, other hormones or neurotransmitters may also activate cascades to crosstalk with estrogen receptor-mediated transcription.The idea of synergistic coupling between membrane-initiated and genomic actions of hormones fundamentally revises the paradigms of cell signaling in neuroendocrinology.(Endocrine Reviews 28: 1-19, 2007) I. Introduction II.Estrogens Signal via Both Genomic and Nongenomic Modes A. The genomic mode of estrogen action B. Membrane-initiated (nongenomic) actions of estrogens: the use of membrane-limited conjugates as an experimental probe in neural cells C. Membrane-initiated (nongenomic) actions of estrogens in neural cells III.Membrane-Initiated Hormone Actions Potentiate Their Transcriptional Actions A. Coupling of the membrane-initiated actions of estrogen to transcription: the consequence for reproductive behavior B. Coupling of membrane-initiated actions of estrogens to transcription in nonreproductive functions C. The coupling of membrane-initiated actions to transcription is studied in vitro by using a two-pulse transcriptional paradigm in cell culture IV.The Signal Transduction Cascades Initiated by Estrogens at the Membrane May Occur in Parallel or in Series A. Membrane-initiated actions of estrogens may also occur in parallel or in series in the MCF-7 breast carcinoma cell line V. Convergence of the Membrane-Initiated Actions of Hormones to Transcription Involves Protein-Protein Interactions, Protein Translocation, and Protein Phosphorylation A. Coupling to transcription via stabilization or dimerization of molecules relevant to transcription B. Coupling to transcription via the physical movement of molecules into the nucleus C. Coupling to transcription via phosphorylation of molecules relevant to transcription VI.Initiation of Membrane-Initiated Actions at the Membrane Involves Both Classical "Nuclear Receptors" and Other Proteins A. The membrane estrogen receptor could be a novel protein in some cell types B. The membrane estrogen receptor is the classical ER in other cell types C. Do different cell types have different receptors?VII.Summary and Future

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Items 201–247 of 247

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DeFranco, D. B., Ramakrishnan, C., & Tang, Y. (1998) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00177-5 · Cited by 61
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Lu, Q. R., Ebling, H. M., Mittler, J., Baur, W. E., & Karas, R. H. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02432-8 · Cited by 55
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Malyala, A., Pattee, P., Nagalla, S. R., Kelly, M. J., & Rønnekleiv, O. K. (2004) · Neurochemical Research · doi:10.1023/b:nere.0000023606.13670.1d · Cited by 47
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Wollmann, W., Goodman, M. L., Bhat‐Nakshatri, P., Kishimoto, H., Goulet, R. J., Mehrotra, S., Morimiya, A., Badve, S., & Nakshatri, H. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi031 · Cited by 45
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Morales, A., Díaz, M. L., Ropero, A. B., Nadal, Á., & Alonso, R. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02997.x · Cited by 44
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Pfaff, D. W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14213 · Cited by 42
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Allouche, S., Polastron, J., Hasbi, A., Homburger, V., & Jauzac, P. (1999) · Biochemical Journal · doi:10.1042/bj3420071 · Cited by 42
Involvement of γ protein kinase C in estrogen‐induced neuroprotection against focal brain ischemia through G protein‐coupled estrogen receptor
Hayashi, S., Ueyama, T., Kajimoto, T., Yagi, K., Kohmura, E., & Saito, N. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03080.x · Cited by 42
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Servi, B. D., Hermani, A., Medunjanin, S., & Mayer, D. (2005) · Oncogene · doi:10.1038/sj.onc.1208676 · Cited by 40
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Ciana, P., Ghisletti, S., Mussi, P., Eberini, I., Vegeto, E., & Maggi, A. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301525200 · Cited by 39
Thyroid hormone can increase estrogen-mediated transcription from a consensus estrogen response element in neuroblastoma cells.
Zhao, X., Lorenc, H. K., Stephenson, H. T., Wang, Y. J., Witherspoon, D. P., Katzenellenbogen, B., Pfaff, D., & Vasudevan, N. (2005) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0501042102 · Cited by 39
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SK-ER3 Neuroblastoma Cells as a Model for the Study of Estrogen Influence on Neural Cells
Agrati, P., Garnier, M. J., Patrone, C., Pollio, G., Santagati, S., Vegeto, E., & Maggi, A. C. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(97)00237-2 · Cited by 37
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Sex and estrogenic effects on coexpression of mRNAs in single ventromedial hypothalamic neurons
Devidze, N., Mong, J. A., Jasnow, A. M., Kow, L., & Pfaff, D. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507144102 · Cited by 32
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Sun, Z., Huang, Y., Zhu, Y.-C., & Yao, T. (2005) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2005.00538.x · Cited by 31
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Mobbs, C. V., Rothfeld, J. M., Saluja, R., & Pfaff, D. W. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90572-8 · Cited by 28
Self-citation
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Differential desensitization of human δ-opioid receptors by peptide and alkaloid agonists
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Self-citation
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Oestradiol-BSA conjugates for receptor histochemistry: problems of stability and interactions with cytosol
Binder, M. (1984) · The Histochemical Journal · doi:10.1007/bf01003854 · Cited by 18
Neural, hormonal and genetic mechanisms for the activation of brain and behavior
Mong, J. A., Easton, A. E., Kow, L., & Pfaff, D. W. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.109 · Cited by 18
Self-citation
Interactions of Insulin-Like Growth Factor-I and Estrogen in the Brain
Méndez, P., Cardona‐Gómez, G. P., & García‐Segura, L. M. (2005) · Advances in experimental medicine and biology · doi:10.1007/0-387-26274-1_12 · Cited by 15
Estrogen affects the expression of Ca2+/calmodulin-dependent protein kinase IV in amygdala
Zhou, J. R., Cohen, R. S., & Pandey, S. C. (2001) · Neuroreport · doi:10.1097/00001756-200109170-00046 · Cited by 15
Molecular mechanisms of crosstalk between thyroid hormones and estrogens
Vasudevan, N., & Pfaff, D. (2005) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/01.med.0000178273.09365.22 · Cited by 15
Self-citation
Rapid modulatory effect of estradiol on acetylcholine‐induced Ca2+signal is mediated through cyclic‐GMP cascade in LHRH‐releasing GT1‐7 cells
Morales, A., Díaz, M. L., Guelmes, P., Marín, R., & Alonso, R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04432.x · Cited by 14
Neuropsychiatric Implications of Thyroid Hormone and Benzodiazepine Interactions
Kragie, L. (1993) · Endocrine Research · doi:10.1080/07435809309035405 · Cited by 11
Thyroid hormone and mood modulation: New insights from functional brain imaging techniques
Bauer, M., & Whybrow, P. C. (2003) · Current Psychiatry Reports · doi:10.1007/s11920-003-0033-1 · Cited by 8

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4 of the 251 references couldn’t be matched to a known paper.

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Pfaff, 1998, Hormonal and environmental control of lordosis behavior: neural and molecular mechanisms., Eur J Neurosci, 10, 330

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Nelson, R. J., & Trainor, B. C. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2174 · Cited by 1,046
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Miller, V. M., & DUCKLES, S. P. (2008) · Pharmacological Reviews · doi:10.1124/pr.107.08002 · Cited by 608
Sex differences in the physiology of eating
Asarian, L., & Geary, N. (2013) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00446.2012 · Cited by 513
Extranuclear Steroid Receptors: Nature and Actions
Hammes, S. R., & Levin, E. R. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0022 · Cited by 475
Uncovering the mechanisms of estrogen effects on hippocampal function
Spencer-Segal, J. L., Waters, E. M., Romeo, R. D., Wood, G. E., Milner, T. A., & McEwen, B. S. (2007) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2007.08.006 · Cited by 430

See all 232

Authors: Vasudevan, N., & Pfaff, D. W.
Affiliations: Pennsylvania State University (US)
Rockefeller University (US)
Corresponding author: Vasudevan, Nandini
ORCID: Vasudevan, Nandini
Pfaff, Donald W.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2007-02-01
Volume: 28
Issue: 1
Pages: 1-19
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2005-0021
OpenAlex: W2153676809
Cited by: 231
References: 251
Citations by year: 2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 15
FWCI: 3.21
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
CentAUR (University of Reading) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: estrogen receptor, nuclear receptor signaling, kinase activation, calcium release, signaling crosstalk, neuroendocrinology, signal transduction
MeSH terms: Animals, Biological Transport, Cell Membrane, Estrogens, Humans, Models, Biological, Nervous System Physiological Phenomena, Neuroendocrinology, Protein Binding, Protein Processing, Post-Translational, Receptors, Estrogen, Transcription, Genetic, Signal Transduction

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Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles

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