CoChat
Sign Up
Cited by 232Estrogen and related hormone effectsReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 247 of the 251 references it cites were found in a registry or an index.

Membrane-Initiated Actions of Estrogens in Neuroendocrinology: Emerging Principles

Vasudevan, Nandini, Pfaff, Donald W.·2007·Endocrine Reviews
DOI 10.1210/er.2005-0021
Open this paper in CoChat — free account

Abstract

Hormonal ligands for the nuclear receptor superfamily have at least two interacting mechanisms of action: 1) classical transcriptional regulation of target genes (genomic mechanisms); and 2) nongenomic actions that are initiated at the cell membrane, which could impact transcription.Although transcriptional mechanisms are increasingly well understood, membrane-initiated actions of these ligands are incompletely understood.Historically, this has led to a considerable divergence of thought in the molecular endocrine field.We have attempted to uncover principles of hormone action that are relevant to membrane-initiated actions of estrogens.There is evidence that the membrane-limited actions of hormones, particularly estrogens, involve the rapid activation of kinases and the release of calcium.Membrane actions of estrogens, which activate these rapid signaling cascades, can also potentiate nuclear transcription.These signaling cascades may occur in parallel or in series but subsequently converge at the level of modification of transcriptionally relevant molecules such as nuclear receptors and/or coactivators.In addition, other hormones or neurotransmitters may also activate cascades to crosstalk with estrogen receptor-mediated transcription.The idea of synergistic coupling between membrane-initiated and genomic actions of hormones fundamentally revises the paradigms of cell signaling in neuroendocrinology.(Endocrine Reviews 28: 1-19, 2007) I. Introduction II.Estrogens Signal via Both Genomic and Nongenomic Modes A. The genomic mode of estrogen action B. Membrane-initiated (nongenomic) actions of estrogens: the use of membrane-limited conjugates as an experimental probe in neural cells C. Membrane-initiated (nongenomic) actions of estrogens in neural cells III.Membrane-Initiated Hormone Actions Potentiate Their Transcriptional Actions A. Coupling of the membrane-initiated actions of estrogen to transcription: the consequence for reproductive behavior B. Coupling of membrane-initiated actions of estrogens to transcription in nonreproductive functions C. The coupling of membrane-initiated actions to transcription is studied in vitro by using a two-pulse transcriptional paradigm in cell culture IV.The Signal Transduction Cascades Initiated by Estrogens at the Membrane May Occur in Parallel or in Series A. Membrane-initiated actions of estrogens may also occur in parallel or in series in the MCF-7 breast carcinoma cell line V. Convergence of the Membrane-Initiated Actions of Hormones to Transcription Involves Protein-Protein Interactions, Protein Translocation, and Protein Phosphorylation A. Coupling to transcription via stabilization or dimerization of molecules relevant to transcription B. Coupling to transcription via the physical movement of molecules into the nucleus C. Coupling to transcription via phosphorylation of molecules relevant to transcription VI.Initiation of Membrane-Initiated Actions at the Membrane Involves Both Classical "Nuclear Receptors" and Other Proteins A. The membrane estrogen receptor could be a novel protein in some cell types B. The membrane estrogen receptor is the classical ER in other cell types C. Do different cell types have different receptors?VII.Summary and Future

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1210/er.2005-0021

Cites

247 of 247 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

1 retracted

Flagged first, then by citations

4 of the 251 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

  1. Pfaff, 1998, Hormonal and environmental control of lordosis behavior: neural and molecular mechanisms., Eur J Neurosci, 10, 330

Cited by

Sorted by citations

See all 232

Related

See all

Metadata

Authors
Vasudevan, N., & Pfaff, D. W.
Affiliations
  • Pennsylvania State University (US)
  • Rockefeller University (US)
Corresponding author
Vasudevan, Nandini
ORCID
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2007-02-01
Volume
28
Issue
1
Pages
1-19
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2005-0021
OpenAlex
W2153676809
Cited by
231
References
251
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 8 · 2017: 11 · 2016: 12 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 15
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • CentAUR (University of Reading) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
estrogen receptor, nuclear receptor signaling, kinase activation, calcium release, signaling crosstalk, neuroendocrinology, signal transduction
MeSH terms
Animals, Biological Transport, Cell Membrane, Estrogens, Humans, Models, Biological, Nervous System Physiological Phenomena, Neuroendocrinology, Protein Binding, Protein Processing, Post-Translational, Receptors, Estrogen, Transcription, Genetic, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review