The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains
Open accessAbstract
Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for blood glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia to induce hepatic glucose output. The control of glucagon secretion is multifactorial and involves direct effects of nutrients on α-cell stimulus-secretion coupling as well as paracrine regulation by insulin and zinc and other factors secreted from neighboring β- and δ-cells within the islet of Langerhans. Glucagon secretion is also regulated by circulating hormones and the autonomic nervous system. In this review, we describe the components of the α-cell stimulus secretion coupling and how nutrient metabolism in the α-cell leads to changes in glucagon secretion. The islet cell composition and organization are described in different species and serve as a basis for understanding how the numerous paracrine, hormonal, and nervous signals fine-tune glucagon secretion under different physiological conditions. We also highlight the pathophysiology of the α-cell and how hyperglucagonemia represents an important component of the metabolic abnormalities associated with diabetes mellitus. Therapeutic inhibition of glucagon action in patients with type 2 diabetes remains an exciting prospect.
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Cites
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Cited by
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743
miR-375 maintains normal pancreatic α- and β-cell mass
Poy, M. N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M., & Stoffel, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810550106 · Cited by 740
Glucagonocentric restructuring of diabetes: A pathophysiologic and therapeutic makeover
Unger, R. H., & Cherrington, A. D. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60016 · Cited by 670
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
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Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition
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Metadata
- Authors
- Gromada, J., Franklin, I., & Wollheim, C. B.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2007-02-01
- Volume
- 28
- Issue
- 1
- Pages
- 84-116
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2154785285
- Cited by
- 581
- References
- 57
- FWCI
- 40.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Gromada, J., Franklin, I., & Wollheim, C. B. (2007). α-Cells of the Endocrine Pancreas: 35 Years of Research but the Enigma Remains. Endocrine Reviews. https://doi.org/10.1210/er.2006-0007
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
