The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition
Open accessAbstract
The pancreatic islet displays diverse patterns of endocrine cell arrangement. The prototypic islet, with insulin-secreting beta-cells forming the core surrounded by other endocrine cells in the periphery, is largely based on studies of normal rodent islets. Recent reports on large animals, including humans, show a difference in islet architecture, in which the endocrine cells are randomly distributed throughout the islet. This particular species difference has raised concerns regarding the interpretation of data based on rodent studies to humans. On the other hand, further variations have been reported in marsupials and some nonhuman primates, which possess an inverted ratio of beta-cells to other endocrine cells. This review discusses the striking plasticity of islet architecture and cellular composition among various species including changes in response to metabolic states within a single species. We propose that this plasticity reflects evolutionary acquired adaptation induced by altered physiological conditions, rather than inherent disparities between species.
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Cites
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Islet architecture: A comparative study
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Cited by
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
Sandoval, D. A., & D'Alessio, D. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00013.2014 · Cited by 498
Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441
Single-Cell Transcriptomics of the Human Endocrine Pancreas
Wang, Y. J., Schug, J., Won, K.-J., Liu, C., Naji, A., Avrahami, D., Golson, M. L., & Kaestner, K. H. (2016) · Diabetes · doi:10.2337/db16-0405 · Cited by 432
Lipotoxicity disrupts incretin-regulated human β cell connectivity
Hodson, D. J., Mitchell, R. K., Bellomo, E. A., Sun, G., Vinet, L., Meda, P., Li, D., Li, W.-H., Bugliani, M., Marchetti, P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68459 · Cited by 210
Brereton, M. F., Vergari, E., Zhang, Q., & Clark, A. (2015) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415583535 · Cited by 206
Metadata
- Authors
- Steiner, D. J., Kim, A., Miller, K., & Hara, M.
- Venue
- Islets
- Publisher
- Informa UK Limited
- Published
- 2010-05
- Volume
- 2
- Issue
- 3
- Pages
- 135-145
- ISSN
- 1938-2014 (ISSN-L)
- 1938-2022
- OpenAlex
- W2014131324
- Cited by
- 494
- References
- 56
- FWCI
- 11.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Steiner, D. J., Kim, A., Miller, K., & Hara, M. (2010). Pancreatic islet plasticity: Interspecies comparison of islet architecture and composition. Islets. https://doi.org/10.4161/isl.2.3.11815
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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