The DOI matches its Crossref record; 152 of the 152 references it cites were found in a registry or an index.
Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy Resistance
Open accessAbstract
Breast cancer evolution and tumor progression are governed by the complex interactions between steroid receptor [estrogen receptor (ER) and progesterone receptor] and growth factor receptor signaling. In recent years, the field of cancer therapy has witnessed the emergence of multiple strategies targeting these specific cancer pathways and key molecules (ER and growth factor receptors) to arrest tumor growth and achieve tumor eradication; treatment success, however, has varied and both de novo (up front) and acquired resistance have proven a challenge. Recent studies of ER biology have revealed new insights into ER action in breast cancer and have highlighted the role of an intimate crosstalk between the ER and HER family signaling pathways as a fundamental contributor to the development of resistance to endocrine therapies against the ER pathway. The aim of this review article is to summarize the current knowledge on mechanisms of resistance of breast cancer cells to endocrine therapies due to the crosstalk between the ER and the HER growth factor receptor signaling pathways and to explore new available therapeutic strategies that could prolong duration of response and circumvent endocrine resistant tumor growth.
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2 retracted
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Cited by
Saura, C., Oliveira, M., Feng, Y.-H., Dai, M.-S., Chen, S.-W., Hurvitz, S. A., Kim, S.-B., Moy, B., Delaloge, S., Gradishar, W., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00147 · Cited by 604
Metadata
- Authors
- Arpino, G., Wiechmann, L., Osborne, C. K., & Schiff, R.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2008-01-23
- Volume
- 29
- Issue
- 2
- Pages
- 217-233
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2022102157
- Cited by
- 549
- References
- 152
- FWCI
- 25.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Arpino, G., Wiechmann, L., Osborne, C. K., & Schiff, R. (2008). Crosstalk between the Estrogen Receptor and the HER Tyrosine Kinase Receptor Family: Molecular Mechanism and Clinical Implications for Endocrine Therapy Resistance. Endocrine Reviews. https://doi.org/10.1210/er.2006-0045
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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