The DOI matches its Crossref record; 363 of the 375 references it cites were found in a registry or an index.
Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex
Abstract
Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual maturation at puberty, and the maintenance of male reproductive function and behavior in adulthood. In addition, androgens affect a wide variety of nonreproductive tissues. Moreover, aberrant androgen action plays a critical role in multiple pathologies, including prostate cancer and androgen insensitivity syndromes. The formation of a productive AR transcriptional complex requires the functional and structural interaction of the AR with its coregulators. In the last decade, an overwhelming and ever increasing number of proteins have been proposed to possess AR coactivating or corepressing characteristics. Intriguingly, a vast diversity of functions has been ascribed to these proteins, indicating that a multitude of cellular functions and signals converge on the AR to regulate its function. The current review aims to provide an overview of the AR coregulator proteins identified to date and to propose a classification of these AR coregulator proteins according to the function(s) ascribed to them. Taken together, this approach will increase our understanding of the cellular pathways that converge on the AR to ensure an appropriate transcriptional response to androgens.
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“Androgen receptors can be modulated by specific proteins called coregulators [70–72] or mediated via the activation of membrane-bound protein receptors to initiate intracellular signalling pathways [73], which can occur even in the presence of low levels of androgens [74].”
From Integrating Transwomen and Female Athletes with Differences of Sex Development (DSD) into Elite Competition: The FIMS 2021 Consensus Statement (2021) · cites this paper as [71]
Citations
Cites
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12 of the 375 references couldn’t be matched to a known paper.
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- Litvinov, 2003, Is the Achilles’ heel for prostate cancer therapy a gain of function in androgen receptor signaling?, J Clin Endocrinol Metab, 88, 2972, 10.1210/jc.2002-022038 · DOI
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The Molecular Taxonomy of Primary Prostate Cancer
Abeshouse, A. A., Ahn, J., Akbani, R., Ally, A., Amin, S. B., Andry, C., Annala, M., Aprikian, A. G., Armenia, J., Arora, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.025 · Cited by 3,126
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Almeida, M., Laurent, M. R., Dubois, V., Claessens, F., O'Brien, C. A., Bouillon, R., Vanderschueren, D., & Manolagas, S. C. (2017) · Physiological Reviews · doi:10.1152/physrev.00033.2015 · Cited by 860
Androgen Receptor Structure, Function and Biology: From Bench to Bedside.
(2016) · Europe PMC (PubMed Central) · Cited by 623
Joseph, J. D., Lu, N., Qian, J., Sensintaffar, J., Shao, G., Brigham, D., Moon, M., Maneval, E. C., Chen, I., Darimont, B. D., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0226 · Cited by 599
Metadata
- Authors
- Heemers, H. V., & Tindall, D. J.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Tindall, Donald J.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2007-10-16
- Volume
- 28
- Issue
- 7
- Pages
- 778-808
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2164092182
- Cited by
- 753
- References
- 375
- Citations by year
- 2026: 12 · 2025: 26 · 2024: 30 · 2023: 29 · 2022: 40 · 2021: 48 · 2020: 26 · 2019: 37 · 2018: 37 · 2017: 38 · 2016: 54 · 2015: 49 · 2014: 42 · 2013: 70 · 2012: 52
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA121277, CA125747, R01CA125747, CA 91956, CA121277, P50CA091956, CA 15083, P30CA015083)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065236, DK65236)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Keywords
- androgen receptor, coregulators, transcriptional coactivator, corepressors, transcriptional complex, androgen signaling, male reproductive development, prostate cancer, androgen insensitivity syndrome
- MeSH terms
- Androgens, Gene Expression Regulation, Humans, Male, Receptors, Androgen, Transcription Factors
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