Cited by 753Prostate Cancer Treatment and ResearchEstrogen and related hormone effectsSperm and Testicular Function

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Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex

Heemers, Hannelore V., Tindall, Donald J.·2007·Endocrine Reviews

DOI 10.1210/er.2007-0019

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Abstract

Androgens, acting through the androgen receptor (AR), are responsible for the development of the male phenotype during embryogenesis, the achievement of sexual maturation at puberty, and the maintenance of male reproductive function and behavior in adulthood. In addition, androgens affect a wide variety of nonreproductive tissues. Moreover, aberrant androgen action plays a critical role in multiple pathologies, including prostate cancer and androgen insensitivity syndromes. The formation of a productive AR transcriptional complex requires the functional and structural interaction of the AR with its coregulators. In the last decade, an overwhelming and ever increasing number of proteins have been proposed to possess AR coactivating or corepressing characteristics. Intriguingly, a vast diversity of functions has been ascribed to these proteins, indicating that a multitude of cellular functions and signals converge on the AR to regulate its function. The current review aims to provide an overview of the AR coregulator proteins identified to date and to propose a classification of these AR coregulator proteins according to the function(s) ascribed to them. Taken together, this approach will increase our understanding of the cellular pathways that converge on the AR to ensure an appropriate transcriptional response to androgens.

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Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily
Oñate, S. A., Tsai, S. Y., Tsai, M., & O’Malley, B. W. (1995) · Science · doi:10.1126/science.270.5240.1354 · Cited by 2,398
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Androgen Receptor Defects: Historical, Clinical, and Molecular Perspectives*
Quigley, C. A., Bellis, A. D., Marschke, K. B., Awady, M. K. E., Wilson, E. M., & French, F. S. (1995) · Endocrine Reviews · doi:10.1210/edrv-16-3-271 · Cited by 1,459
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Regulation of Transcription by a Protein Methyltransferase
Chen, D., Ma, H., Hong, H., Koh, S. S., Huang, S., Schurter, B. T., Aswad, D. W., & Stallcup, M. R. (1999) · Science · doi:10.1126/science.284.5423.2174 · Cited by 1,214
Steroid 5α-reductase: two genes/two enzymes
Russell, D. W., & Wilson, J. D. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000325 · Cited by 1,105

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van de Wijngaart, D. J., Dubbink, H. J., van Royen, M. E., Trapman, J., & Jenster, G. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.08.007 · Cited by 122
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Moses, M. A., Kim, Y. S., Rivera-Márquez, G. M., Oshima, N., Watson, M. J., Beebe, K. E., Wells, C., Lee, S., Zuehlke, A. D., Shao, H., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-3728 · Cited by 119
Endogenous androgen receptor proteomic profiling reveals genomic subcomplex involved in prostate tumorigenesis
Stelloo, S., Nevedomskaya, E., Kim, Y., Hoekman, L., Bleijerveld, O. B., Mirza, T., Wessels, L. F. A., van Weerden, W. M., Altelaar, A. F. M., Bergman, A. M., et al. (2018) · Oncogene · doi:10.1038/onc.2017.330 · Cited by 118
Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation
Assimon, V. A., Southworth, D. R., & Gestwicki, J. E. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00801 · Cited by 112
Androgen regulation of gene expression.
(2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)07005-3 · Cited by 117
Self-citation
Molecular Alterations during Progression of Prostate Cancer to Androgen Independence
Saraon, P., Jarvi, K. A., & Diamandis, E. P. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.165977 · Cited by 115
SUMO-Specific Protease 1 (SENP1) Reverses the Hormone-Augmented SUMOylation of Androgen Receptor and Modulates Gene Responses in Prostate Cancer Cells
Kaikkonen, S., Jääskeläinen, T. J., Karvonen, U., Rytinki, M. M., Makkonen, H., Gioeli, D. G., Paschal, B. M., & Palvimo, J. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2008-0219 · Cited by 114
Increased Expression of Androgen Receptor Coregulator MAGE-11 in Prostate Cancer by DNA Hypomethylation and Cyclic AMP
Karpf, A. R., Bai, S., James, S. R., Mohler, J. L., & Wilson, E. M. (2009) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0400 · Cited by 117
Anti-androgenic mechanisms of Bisphenol A involve androgen receptor signaling pathway
Wang, H., Ding, Z., Shi, Q.-M., Ge, X., Wang, H.-X., Li, M.-X., Chen, G., Wang, Q., Ju, Q., Zhang, J., et al. (2017) · Toxicology · doi:10.1016/j.tox.2017.06.007 · Cited by 113
CBP/p300: Critical Co-Activators for Nuclear Steroid Hormone Receptors and Emerging Therapeutic Targets in Prostate and Breast Cancers
Waddell, A. R., Huang, H., & Liao, D. (2021) · Cancers · doi:10.3390/cancers13122872 · Cited by 110
A Combination of H2A.Z and H4 Acetylation Recruits Brd2 to Chromatin during Transcriptional Activation
Draker, R., Ng, M. K., Sarcinella, E., Ignatchenko, V., Kislinger, T., & Cheung, P. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003047 · Cited by 118
The mineralocorticoid receptor and its coregulators
Yang, J., & Young, M. J. (2009) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0031 · Cited by 120
Association of Androgen Receptor CAG Repeat Polymorphism and Polycystic Ovary Syndrome
Shah, N. A., Antoine, H. J., Pall, M., Taylor, K. D., Azziz, R., & Goodarzi, M. O. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0038 · Cited by 108
The hallmarks of castration-resistant prostate cancers
Katsogiannou, M., Ziouziou, H., Karaki, S., Andrieu, C., de Villeneuve, M. H., & Rocchi, P. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.05.003 · Cited by 118
Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor
Zhou, X., Suino-Powell, K. M., Li, J., He, Y., MacKeigan, J. P., Melcher, K., Yong, E., & Xu, H. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085779 · Cited by 105
Progression of prostate cancer: Multiple pathways to androgen independence
Devlin, H.-L., & Mudryj, M. M. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.06.007 · Cited by 102
Prognostic significance of androgen receptor expression in invasive breast cancer: transcriptomic and protein expression analysis
Aleskandarany, M. A., Abduljabbar, R. F., Ashankyty, I., Elmouna, A., Jerjees, D. A., Ali, S., Buluwela, L., Diez, M., Caldas, C., Green, A. R., et al. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3934-5 · Cited by 101
Hormonal regulation of CYP1A expression
Monostory, K., Pascussi, J., Kob́ori, L., & Dvořák, Z. (2009) · Drug Metabolism Reviews · doi:10.1080/03602530903112284 · Cited by 102
Androgen receptor genomic regulation.
Jin, H., Kim, J., & Yu, J. (2013) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2223-4683.2013.09.01 · Cited by 103
The Androgen Receptor and VEGF: Mechanisms of Androgen-Regulated Angiogenesis in Prostate Cancer
Eisermann, K., & Fraizer, G. C. (2017) · Cancers · doi:10.3390/cancers9040032 · Cited by 97
Abiraterone acetate in the treatment of prostate cancer
Thakur, A., Roy, A., Ghosh, A., Chhabra, M., & Banerjee, S. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.067 · Cited by 97
Androgen Receptor (AR) Pathophysiological Roles in Androgen Related Diseases in Skin, Metabolism Syndrome, Bone/Muscle and Neuron/Immune Systems: Lessons Learned from Mice Lacking AR in Specific Cells
Chang, C., Yeh, S., Lee, S. O., & Chang, T. (2013) · Nuclear Receptor Signaling · doi:10.1621/nrs.11001 · Cited by 92
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
Valdés‐Mora, F., Gould, C. M., Colino‐Sanguino, Y., Qu, W., Song, J. Z., Taylor, K. M., Buske, F. A., Statham, A. L., Nair, S. S., Armstrong, N. J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01393-8 · Cited by 92
Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer
Yang, Y., Jia, D., Kim, H., Elmageed, Z. Y. A., Datta, A., Davis, R., Srivastav, S., Moroz, K., Crawford, B. E., Moparty, K., et al. (2015) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-1606 · Cited by 89

Authors: Heemers, H. V., & Tindall, D. J.
Affiliations: Mayo Clinic (US)
Corresponding author: Tindall, Donald J.
ORCID: Heemers, Hannelore V.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 2007-10-16
Volume: 28
Issue: 7
Pages: 778-808
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/er.2007-0019
OpenAlex: W2164092182
Cited by: 753
References: 375
Citations by year: 2026: 12 · 2025: 26 · 2024: 30 · 2023: 29 · 2022: 40 · 2021: 48 · 2020: 26 · 2019: 37 · 2018: 37 · 2017: 38 · 2016: 54 · 2015: 49 · 2014: 42 · 2013: 70 · 2012: 52
FWCI: 5.79
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA121277, CA125747, R01CA125747, CA 91956, CA121277, P50CA091956, CA 15083, P30CA015083)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065236, DK65236)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Prostate Cancer Treatment and Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: androgen receptor, coregulators, transcriptional coactivator, corepressors, transcriptional complex, androgen signaling, male reproductive development, prostate cancer, androgen insensitivity syndrome
MeSH terms: Androgens, Gene Expression Regulation, Humans, Male, Receptors, Androgen, Transcription Factors

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Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex

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