The DOI matches its Crossref record; 272 of the 273 references it cites were found in a registry or an index.
Fibroblast Growth Factor 21—Metabolic Role in Mice and Men
Open accessAbstract
Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very robust data documenting this factor's favorable effects on glucose and lipid metabolism in mice.For more than ten years now, intense in vivo and ex vivo experimentation addressed the physiological functions of FGF21 in humans as well as its pathophysiological role and pharmacological effects in human metabolic disease.This work produced a comprehensive collection of data revealing overlaps in FGF21 expression and function but also significant differences between mice and humans that have to be considered before translation from bench to bedside can be successful.This review summarizes what is known about FGF21 in mice and humans with a special focus on this factor's role in glucose and lipid metabolism and in metabolic diseases, such as obesity and type 2 diabetes mellitus.We highlight the discrepancies between mice and humans and try to decipher their underlying reasons.(Endocrine Reviews 38: 468 -488, 2017) W ith a prevalence of ~% in adults, type diabetes mellitus (TD) is the most prominent metabolic disease worldwide (World Health Organization fact sheet on diabetes at http://www.who. int/mediacentre/factsheets/fs/en).The hallmark of the disease, that is, hyperglycemia, results from insulin resistance of liver, skeletal muscle, adipose tissue, and brain and a concomitant failure of pancreatic b-cells to compensate for this resistance by increased insulin secretion ().Current therapeutic options aim at reducing insulin resistance (metformin, thiazolidinediones), enhancing insulin secretion (sulfonylureas, meglitinides, dipeptidyl peptidase IV inhibitors, incretin mimetics), or excreting glucose via the urine (sodium/glucose cotransporter inhibitors), but a progressive loss of b-cell function and mass is often observed ().Eventually, the ultima ratio to normalize blood glucose is the replacement of endogenous insulin by injection of human recombinant insulin or insulin analogs.New insights into the molecular pathomechanisms behind insulin resistance and b-cell failure point toward a crucial role for a well-balanced humoral crosstalk between metabolically relevant tissues (e.g., adipose, muscle, liver).Highly relevant players and promising targets for novel therapeutic strategies in this crosstalk were recently identified, among them fibroblast growth factor (FGF) (-).FGF is an endocrine factor secreted by liver acting as a metabolic regulator.Interest in the metabolic effects of FGF was aroused by the emergence of FGF as hit in an in vitro assay testing secreted proteins of unknown function for stimulation of glucose uptake in murine T-L adipocytes in an insulin-independent manner ().Based mainly on preclinical studies in mice showing improvements in glucose and lipid metabolism, FGF emerged as an interesting new candidate for TD treatment,
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“FGF21 mainly binds to FGFR1 (FGFR1b and FGFR1c) and to a lower extent to FGFR4.33”
From Fibroblast growth factor 21 controls mitophagy and muscle mass (2019) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human
Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok, J., Warren, H. S., Cuenca, A. G., Mindrinos, M. N., Baker, H. V., Xu, W., Richards, D. R., McDonald-Smith, G. P., Gao, H., Hennessy, L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222878110 · Cited by 3,005
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
Badman, M. K., Pissios, P., Kennedy, A. R., Koukos, G., Flier, J. S., & Maratos-Flier, E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.002 · Cited by 1,495
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis
Fisher, F. M., Kleiner, S., Douris, N., Fox, E. C., Mepani, R. J., Verdeguer, F., Wu, J., Kharitonenkov, A., Flier, J. S., Maratos-Flier, E., et al. (2012) · Genes & Development · doi:10.1101/gad.177857.111 · Cited by 1,478
Pathogenesis of type 2 diabetes mellitus
DeFronzo, R. A. (2004) · Medical Clinics of North America · doi:10.1016/j.mcna.2004.04.013 · Cited by 1,342
Receptor Specificity of the Fibroblast Growth Factor Family
Zhang, X., Ibrahimi, O. A., Olsen, S. K., Umemori, H., Mohammadi, M., & Ornitz, D. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601252200 · Cited by 1,164
Cited by
Sorted by citations
Items 101–200 of 268
Hepatic p38 Activation Modulates Systemic Metabolism Through FGF21-Mediated Interorgan Communication
Liu, W., Sun, C., Yan, Y., Cao, H., Niu, Z., Shen, S., Liu, S., Wu, Y., Yan, L., Hui, L., et al. (2021) · Diabetes · doi:10.2337/db21-0240 · Cited by 24
Exercise and Metabolic Health: The Emerging Roles of Novel Exerkines
Yazgan, B., Türkel, İ., Özerkliğ, B., ATAKAN, M. M., Aktitiz, S., & Koşar, Ş. N. (2022) · Current Protein and Peptide Science · doi:10.2174/1389203723666220629163524 · Cited by 25
Cho, J. M., Yang, E. H., Quan, W., Nam, E. H., & Cheon, H. G. (2020) · Scientific Reports · doi:10.1038/s41598-020-77978-z · Cited by 24
Estrogen-Wnt signaling cascade regulates expression of hepatic fibroblast growth factor 21
Badakhshi, Y., Shao, W., Liu, D., Tian, L., Pang, J., Gu, J., Hu, J., & Jin, T. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00638.2020 · Cited by 23
Lee, D., Tomita, Y., Jeong, H., Miwa, Y., Tsubota, K., Negishi, K., & Kurihara, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179408 · Cited by 24
Chang, J. S., & Namkung, J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18052242 · Cited by 22
Geißler, C., Krause, C., Neumann, A., Britsemmer, J. H., Taege, N., Grohs, M., Kaehler, M., Cascorbi, I., Lewis, A. G., Seeley, R. J., et al. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108907 · Cited by 22
Panaro, B. L., Coppage, A. L., Beaudry, J. L., Varin, E. M., Kaur, K., Lai, J. H.-S., Wu, W., Liu, Y., Bachovchin, W. W., & Drucker, D. J. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.011 · Cited by 22
Kosugi, R., Nakatani, E., Okamoto, K., Aoshima, S., Arai, H., & Inoue, T. (2019) · Endocrine Journal · doi:10.1507/endocrj.ej19-0013 · Cited by 21
Metabolic Factors Determining the Susceptibility to Weight Gain: Current Evidence
Hollstein, T., & Piaggi, P. (2020) · Current Obesity Reports · doi:10.1007/s13679-020-00371-4 · Cited by 24
Tas, E., Bai, S., Ou, X., Mercer, K. E., Lin, H., Mansfield, K., Buchmann, R. F., Diaz, E. C., Oden, J. D., Børsheim, E., et al. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00654 · Cited by 20
Current understanding and controversies on the clinical implications of fibroblast growth factor 21
Badakhshi, Y., & Jin, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1864278 · Cited by 20
The endocrine role of hepatokines: implications for human health and disease
Iglesias, P. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1663353 · Cited by 23
Wang, J., Zhong, M.-Y., Liu, Y., Yu, J.-Y., Wang, Y., Zhang, X., & Sun, H. (2024) · Acta Pharmacologica Sinica · doi:10.1038/s41401-024-01417-2 · Cited by 19
Linares, G. R., Leng, Y., Maric, D., & Chuang, D. (2020) · Cell Biology International · doi:10.1002/cbin.11409 · Cited by 19
Telgenkamp, I., Kusters, Y. H. A. M., Schalkwijk, C. G., Houben, A. J. H. M., Kooi, M. E., Lindeboom, L., Bons, J. A. P., Schaper, N. C., Joris, P. J., Plat, J., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02378 · Cited by 18
Fibroblast growth factor 21: update on genetics and molecular biology
Barros, D. R., & Hegele, R. A. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000960 · Cited by 18
Yang, N., Zhang, Y., Huang, Y., Yan, J., Qian, Z., Li, H., Luo, P., Yang, Z. L., Luo, M., Wei, X., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166558 · Cited by 18
Fibroblast growth factors 19 and 21 in acute liver damage
Shan, Z., Álvarez‐Sola, G., Uriarte, I., Arechederra, M., Fernández‐Barrena, M. G., Berasain, C., Ju, C., & Avila, M. A. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.05.26 · Cited by 19
Mutsnaini, L., Kim, C.-S., Kim, J., Joe, Y., Chung, H., Choi, H., Roh, E., Kim, M., & Yu, R. (2019) · Inflammation Research · doi:10.1007/s00011-019-01222-2 · Cited by 18
Lee, D., Tomita, Y., Miwa, Y., Jeong, H., Mori, K., Tsubota, K., & Kurihara, T. (2021) · Pharmaceuticals · doi:10.3390/ph14030223 · Cited by 18
Li, X., Shen, H., Zhou, T., Cao, X., Chen, Y., Liang, Y., Lu, T., He, J., Dou, Z., Liu, C., et al. (2021) · Respiratory Research · doi:10.1186/s12931-021-01778-w · Cited by 18
Johansson, K. S., Sonne, D. P., Knop, F. K., & Christensen, M. (2020) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2020.1791078 · Cited by 17
Regulation of diurnal energy balance by mitokines
Klaus, S., Gil, C. I., & Ost, M. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03748-9 · Cited by 19
Postprandial dynamics and response of fibroblast growth factor 21 in older adults
Herpich, C., Haß, U., Kochlik, B., Franz, K., Laeger, T., Klaus, S., Bosy‐Westphal, A., & Norman, K. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.04.037 · Cited by 17
Moro, J., Chaumontet, C., Even, P. C., Blais, A., Piedcoq, J., Gaudichon, C., Tomé, D., & Azzout‐Marniche, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-91274-4 · Cited by 17
Fibroblast growth factor 21 in dairy cows: current knowledge and potential relevance
Eder, K., Geßner, D. K., & Ringseis, R. (2021) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-021-00621-y · Cited by 18
The crosstalk between fibroblast growth factor 21 (FGF21) system and substance use
Wang, T., Tyler, R. E., Ilaka, O., Cooper, D., Farokhnia, M., & Leggio, L. (2024) · iScience · doi:10.1016/j.isci.2024.110389 · Cited by 18
Xiao, F., Zeng, J., Huang, P., Yan, B., Zeng, X., Liu, C., Shi, X., Wang, L., Song, H., Lin, M., et al. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00800 · Cited by 16
Trusz, G. J. (2024) · Differentiation · doi:10.1016/j.diff.2024.100793 · Cited by 15
Mäkelä, A. M., Hohtola, E., Miinalainen, I., Autio, J. A., Schmitz, W., Niemi, K. J., Hiltunen, J. K., & Autio, K. J. (2019) · Scientific Reports · doi:10.1038/s41598-019-48562-x · Cited by 15
Arlien-Søborg, M. C., Grøndahl, C., Bæk, A., Dal, J., Madsen, M. A., Høgild, M. L., Pedersen, S. B., Bjerre, M., & Jørgensen, J. O. L. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz033 · Cited by 15
Wang, Z., Yuan, M., Xu, C., Zhang, Y., Ying, C., & Xiao, X. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.630287 · Cited by 16
Buell‐Acosta, J. D., Garcés, M. F., Baños, A. J. P., Ángel‐Müller, E., Páez, M. C., Eslava-Schmalbach, J. H., Escobar-Córdoba, F., Caminos-Cepeda, S. A., Lacunza, E., Castano, J. P., et al. (2022) · Cells · doi:10.3390/cells11142251 · Cited by 15
Molecular and cellular regulation of thermogenic fat
Wang, C., Wang, X., & Hu, W. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215772 · Cited by 14
FGF21 Signaling Exerts Antifibrotic Properties during Pulmonary Fibrosis
Ghanem, M., Archer, G., Justet, A., Jaillet, M., Vasarmidi, E., Mordant, P., Castier, Y., Mal, H., Cazes, A., Poté, N., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202311-2021oc · Cited by 16
Usui, N., Yoshida, M., Takayanagi, Y., Nasanbuyan, N., Inutsuka, A., Kurosu, H., Mizukami, H., Mori, Y., Kuro‐o, M., & Onaka, T. (2021) · Journal of Neuroendocrinology · doi:10.1111/jne.13026 · Cited by 13
Wang, J., Meng, X., Jialun, Y., Tang, Y., Zeng, F., Wang, Y., Chen, Z., Chen, D., Zou, R., & Liu, W. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04350-w · Cited by 15
Schnapp, G., Hoevels, Y., Bakker, R. A., Schreiner, P., Klein, T., & Nar, H. (2020) · ChemMedChem · doi:10.1002/cmdc.202000591 · Cited by 13
Stone, S., Wegner, D., Wambach, J., Cole, F. S., Urano, F., & Ornitz, D. M. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa138 · Cited by 12
Wada, Y., Izumi, H., Shimizu, T., & Takeda, Y. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz223 · Cited by 13
Płatek, T., Polus, A., Góralska, J., Raźny, U., Dziewońska, A., Micek, A., Dembinska-Kiec, A., Solnica, B., & Malczewska-Malec, M. (2021) · Genes · doi:10.3390/genes12020307 · Cited by 12
Liu, X., Graham, Z., Harlow, L., Pan, J., Azulai, D., Bauman, W. A., Yarrow, J. F., & Cardozo, C. P. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.668984 · Cited by 12
Meroni, M., Dongiovanni, P., Tiano, F., Piciotti, R., Alisi, A., & Panera, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117608 · Cited by 13
Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice
Homer-Bouthiette, C., Xiao, L., & Hurley, M. M. (2021) · Scientific Reports · doi:10.1038/s41598-021-90565-0 · Cited by 13
Increased plasma apoM levels impair triglyceride turnover in mice
Hajny, S., Borup, A., Elsøe, S., & Christoffersen, C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.158969 · Cited by 13
Alemán, G., Castro, A. L., Vigil‐Martínez, A., Torre-Villalvazo, I., Díaz‐Villaseñor, A., Noriega, L. G., Vera, I., Ordáz, G., Torres, N., & Tovar, A. R. (2019) · Genes & Nutrition · doi:10.1186/s12263-019-0642-x · Cited by 12
Wu, Y., Shi, T., Wang, J., & He, R. (2020) · Obesity · doi:10.1002/oby.23058 · Cited by 12
Xiao, M., Tang, Y., Wang, S., Wang, J., Wang, J., Guo, Y., Zhang, J., & Gu, J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.598008 · Cited by 12
FGF21: A Sharp Weapon in the Process of Exercise to Improve NAFLD
Wang, Z., Sun, T., Yu, J., Li, S., Gong, L., & Zhang, Y. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2812351 · Cited by 12
Ghanem, M., Archer, G., Crestani, B., & Mailleux, A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108669 · Cited by 12
Gómez-Sámano, M. Á., Vargas-Abonce, V. P., Martínez‐Sánchez, F. D., Palacios-Báez, L., Vera-Zertuche, J. M., Navarro-Flores, M. F., Morales-García, M., Fonseca-Correa, J. I., Zuarth-Vázquez, J. M., Vega‐Vega, O., et al. (2021) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188211001160 · Cited by 11
Qian, Z., Zhang, Y., Yang, N., Nie, H., Yang, Z. L., Luo, P., Wei, X., Guan, Y., Huang, Y., Yan, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.984828 · Cited by 11
Cheng, M.-H., Zheng, W., Zhang, Q., Liu, Z., Chen, J.-F., Atta, M., & Qin, H. (2023) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109278 · Cited by 10
Li, Y., Zhong, W., & Tang, X. (2021) · Stem Cells International · doi:10.1155/2021/9929128 · Cited by 12
Metformin Improves the Prerequisites for FGF21 Signaling in Patients With Type 2 Diabetes
Pedersen, A. K. N., Gormsen, L. C., Nielsen, S., Jessen, N., & Bjerre, M. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad583 · Cited by 10
Negroiu, C. E., Tudorașcu, I., Beznă, M. C., Ungureanu, A., Honţaru, S. O., & Dănoiu, S. (2024) · Romanian Journal of Morphology and Embryology · doi:10.47162/rjme.65.2.02 · Cited by 11
Current Treatment Regimens and Promising Molecular Therapies for Chronic Hepatobiliary Diseases
Durazzo, M., Ferro, A., Navarro‐Tableros, V., Gaido, A., Fornengo, P., Altruda, F., Romagnoli, R., Moestrup, S. K., Calvo, P. L., & Fagoonee, S. (2025) · Biomolecules · doi:10.3390/biom15010121 · Cited by 11
Filimidou, I., Orfanidou, M., Goulas, A., Γιουλεμέ, Ό., & Pοlyzos, S. A. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00643-x · Cited by 10
Fibroblast Growth Factor 21 Predicts and Promotes Vascular Calcification in Haemodialysis Patients
Jiang, L., Yin, Q., Yang, M., Li, M., Pan, M., Han, Y., Zhao, Z., Zhi, W., Zhu, L., Wei, Q., et al. (2021) · Kidney Diseases · doi:10.1159/000512750 · Cited by 10
Geßner, D. K., Sandrock, L. M., Most, E., Koch, C., Ringseis, R., & Eder, K. (2022) · Animals · doi:10.3390/ani13010131 · Cited by 10
Vázquez, P., Hernández‐Sánchez, C., Escalona-Garrido, C., Pereira, L., Contreras, C., López, M., Balsinde, J., de Pablo, F., & Valverde, Á. M. (2018) · Journal of Lipid Research · doi:10.1194/jlr.m085209 · Cited by 10
Alsaleem, M. A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Abdel‐Fattah, M. M., Alrouji, M., Al‐Harchan, N. A., Alruwaili, M., Papadakis, M., Alexiou, A. T., & Batiha, G. E. (2025) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70378 · Cited by 9
Physical Exercise-Induced FGF-21 to Fight Obesity: An Update Review
Vecchiatto, B., de Castro, T. L., Muller, C. R., Azevedo‐Martins, A. K., & Evangelista, F. S. (2022) · Obesities · doi:10.3390/obesities2040031 · Cited by 9
Lee, D., Nakai, A., Miwa, Y., Negishi, K., Tomita, Y., & Kurihara, T. (2023) · PeerJ · doi:10.7717/peerj.14611 · Cited by 9
Relationship of HIV Status and Fatigue, Cardiorespiratory Fitness, Myokines, and Physical Activity
Webel, A. R., Jenkins, T. L., Longenecker, C. T., Vest, M., Davey, C. H., Currie, J., Darrah, R. J., Litman, P., Oliveira, V. H. F., & Josephson, R. (2019) · Journal of the Association of Nurses in AIDS Care · doi:10.1097/jnc.0000000000000022 · Cited by 10
Aleem, M., Maqsood, H., Younus, S., Zafar, A. F., Talpur, A. S., & Shakeel, H. A. (2021) · Cureus · doi:10.7759/cureus.17723 · Cited by 9
Ren, F., Huang, J., Dai, T., & Gan, F. (2021) · Annals of Palliative Medicine · doi:10.21037/apm-21-525 · Cited by 8
Molecular epigenetics in the transition of white to brown fat
Chaturvedi, S., Chaturvedi, P., Gupta, P. C., Awasthi, S. K., & Kalani, A. (2025) · Pathology - Research and Practice · doi:10.1016/j.prp.2025.156073 · Cited by 8
Mana, M. F., Parisi, M. C. R., Corrêa‐Giannella, M. L., Neto, A. M., Yamanaka, A., Cunha‐Silva, M., Cavaleiro, A. M., dos Santos, C. R., Pavan, C. R., Sevá‐Pereira, T., et al. (2022) · Molecules · doi:10.3390/molecules27103193 · Cited by 8
Zhu, L., Li, M., Zha, Q., Yang, M., Yu, J., Pan, M., Yin, Q., Jiang, L., Xia, M., Liu, B., et al. (2021) · BMC Nephrology · doi:10.1186/s12882-021-02393-z · Cited by 8
Fibroblast growth factor 21: A role in cardiometabolic disorders and cardiovascular risk prediction?
Katsiki, N., & Mantzoros, C. S. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.005 · Cited by 8
Taniguchi, H., Shimizu, K., Wada, S., Nirengi, S., Kataoka, H., & Higashi, A. (2020) · Journal of PHYSIOLOGICAL ANTHROPOLOGY · doi:10.1186/s40101-020-00226-w · Cited by 8
Liu, J., & Dalamaga, Μ. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100153 · Cited by 8
An update on current type 2 diabetes mellitus (T2DM) druggable targets and drugs targeting them
Uniyal, P., Panwar, S., Bhatt, A., Marianesan, A. B., Kumar, R., Singh, T. G., Tyagi, Y., Bushi, G., Gaidhane, A. M., & Kumar, B. (2025) · Molecular Diversity · doi:10.1007/s11030-025-11149-y · Cited by 11
Zhang, H., Xiong, P., Zheng, T., Hu, Y., Guo, P., Shen, T., & Zhou, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094170 · Cited by 7
Molnár, Á., Szentpéteri, A., Lőrincz, H., Seres, I., Harangi, M., Balogh, Z., Kempler, P., Paragh, G., & Sztanek, F. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305160 · Cited by 7
Localization of FGF21 Protein and Lipid Metabolism-Related Genes in Camels
Gao, Y., Zhao, S., Zhang, W., Tang, H., Yan, M., Yong, F., Bai, X., Wu, X., Zhang, Y., & Zhang, Q. (2023) · Life · doi:10.3390/life13020432 · Cited by 7
Roles of FGF21 and irisin in obesity-related diabetes and pancreatic diseases
Xie, T., & Leung, P. S. (2020) · Journal of Pancreatology · doi:10.1097/jp9.0000000000000039 · Cited by 7
Märtens, H. (2020) · Journal of Agricultural Science · doi:10.5539/jas.v12n3p1 · Cited by 7
Taniguchi, H., Nirengi, S., Ishihara, K., & Sakane, N. (2022) · PLoS ONE · doi:10.1371/journal.pone.0263774 · Cited by 7
Chiu, L.-T., Wang, C., Lin, Y., & Hsu, B. (2022) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2022.05.007 · Cited by 7
Fibroblast growth factor 21 ameliorates cholestatic liver injury via a hepatic FGFR4-JNK pathway
Zhou, C., Pan, X., Huang, L., Wu, T., Zhao, T., Qi, J., Wu, J., Mukondiwa, A. V., Tang, Y., Luo, Y., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166870 · Cited by 7
Magno, A. L., Herat, L. Y., Kiuchi, M. G., Schlaich, M. P., Ward, N. C., & Matthews, V. B. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092764 · Cited by 7
Carroll, H. A., Chen, Y., Templeman, I., James, L. J., Betts, J. A., & Trim, W. V. (2020) · PLoS ONE · doi:10.1371/journal.pone.0235557 · Cited by 6
Li, Y., Lin, M., Lin, P., Xia, N., Li, X., Lin, L., & Yang, Y. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.731698 · Cited by 7
GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD
Jiang, H., & Zang, L. (2024) · Current Pharmaceutical Design · doi:10.2174/0113816128283153231226103218 · Cited by 6
Gehring, J., Azzout‐Marniche, D., Chaumontet, C., Piedcoq, J., Gaudichon, C., & Even, P. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00246.2021 · Cited by 7
Yan, A., Zhao, Y., Zhang, L., Liang, X., Zhang, X., Liang, F., Nian, S., Li, X., Sun, Z., Li, K., et al. (2022) · Open Life Sciences · doi:10.1515/biol-2022-0095 · Cited by 5
The liver-bone axis: an emerging player in disease pathogenesis and therapeutic intervention
Han, S., Wei, Y., Yu, G., Jia, W., Liao, W., He, Y., Cheng, K., Zhao, J., Xiang, S., Zhang, W., et al. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3207-5 · Cited by 5
Role of FGF21 and Leptin for the Diagnosis of Metabolic Health in Children with and without Obesity
Domouzoglou, E. M., Vlahos, A. P., Papafaklis, M. I., Cholevas, V., Chaliasos, N., Siomou, E. C., Michalis, L. K., Tsatsoulis, A. A., & Naka, K. Κ. (2023) · Journal of Personalized Medicine · doi:10.3390/jpm13121680 · Cited by 5
Abudigin, W. I., Bajaber, A. S., & Subash‐Babu, P. (2024) · BMC Nutrition · doi:10.1186/s40795-024-00881-7 · Cited by 5
Impact of Acutely Increased Endogenous- and Exogenous Ketone Bodies on FGF21 Levels in Humans
Lauritzen, E. S., Svart, M. V., Voss, T. S., Møller, N., & Bjerre, M. (2020) · Endocrine Research · doi:10.1080/07435800.2020.1831015 · Cited by 5
UPRmt-regulated mitokines: novel strategies for myocardial injury repair
Gao, W., Liu, J., Zhang, W., Liu, B., & Shen, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1652353 · Cited by 4
Hjort, L., Albrechtsen, N. J. W., Minja, D. T. R., Rasmussen, C. B., Møller, S. L., Lusingu, J., Theander, T. G., Bygbjerg, I. C., Schmiegelow, C., & Grunnet, L. G. (2023) · Journal of the Endocrine Society · doi:10.1210/jendso/bvad120 · Cited by 3
Potential role of Akt in the regulation of fibroblast growth factor 21 by berberine
Hirai, T., Wang, W., Murono, N., Iwasa, K., & Inoue, M. (2023) · Journal of Natural Medicines · doi:10.1007/s11418-023-01755-1 · Cited by 4
Bourdon, G., Chevaleyre, C., Estienne, A., Péchoux, C., Bourgeais, J., Hérault, O., Ba, M., Ramé, C., Dupont, J., Ducluzeau, P., et al. (2024) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2024.112350 · Cited by 2
Zhao, Y., Zhang, L., Liang, X., Zhang, X., Chang, J.-R., Shi, M., Liu, H., Zhou, Y. M., Sun, Z., & Zhao, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105490 · Cited by 4
Shestopalov, A., Ganenko, L. A., Grigoryeva, T. V., Laikov, A. V., Vasilyev, I., Kolesnikova, I. M., Naboka, Y., Volkova, N., & Roumiantsev, S. A. (2023) · Bulletin of Russian State Medical University · doi:10.24075/brsmu.2023.004 · Cited by 4
Vineetha, K. R., Santha, K., Inmozhi, R., Periyasamy, S., Kanakasabai, G., & Baskaran, K. (2020) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20205302 · Cited by 4
Metadata
- Authors
- Staiger, H., Keuper, M., Berti, L., Hrabě de Angelis, M., & Häring, H.-U.
- Affiliations
- Helmholtz Munich (DE)
- Institute of Experimental Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany
- Corresponding author
- Staiger, Harald
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2017-07-28
- Volume
- 38
- Issue
- 5
- Pages
- 468-488
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W2741980484
- Cited by
- 270
- References
- 273
- Citations by year
- 2026: 12 · 2025: 23 · 2024: 25 · 2023: 27 · 2022: 36 · 2021: 64 · 2020: 33 · 2019: 33 · 2018: 16 · 2017: 1
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Endocrine Reviews (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion, other-oa)
- Site cant be reached (submittedVersion, other-oa)
- PuSH - Publication Server of Helmholtz Zentrum München (submittedVersion)
- Funders
- Eberhard Karls Universität Tübingen
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › GDF15 and Related Biomarkers
- Keywords
- FGF21, hepatokines, glucose metabolism, lipid metabolism, type 2 diabetes, obesity, insulin resistance, beta-cell dysfunction, metabolic disorders, translational research, therapeutic target, adipose tissue, liver, skeletal muscle, gut microbiota, gut-liver axis, gut-brain axis
- MeSH terms
- Adipose Tissue, Animals, Bone and Bones, Brain, Diabetes Mellitus, Type 2, Fatty Liver, Fibroblast Growth Factors, Glucose, Humans, Metabolic Diseases, Nutritional Physiological Phenomena, Obesity, Signal Transduction, Exercise, Lipid Metabolism, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
