The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Prevalence and Predictors of Coronary Artery Calcification in Women with Polycystic Ovary Syndrome
Abstract
Polycystic ovary syndrome (PCOS), a common endocrine disorder of reproductive-aged women, is associated with multiple risk factors for coronary heart disease (CHD), such as diabetes mellitus, dyslipidemia, visceral obesity, and hypertension. However, premature coronary atherosclerosis has not been demonstrated in PCOS women. Electron beam computed tomography (EBCT) noninvasively measures coronary artery calcium (CAC), a marker for coronary atherosclerosis. We measured CAC by EBCT in 30- to 45-yr-old premenopausal PCOS women and compared the results to CAC in 1) recruited normal ovulatory volunteers matched for age and weight to the PCOS cohort, and 2) community-dwelling women of similar age in an extant coronary calcium database. Healthy, community-dwelling, ovulatory controls (n = 71) were matched by age and body mass index (BMI) to PCOS women (n = 36). Women with diabetes or known CHD were excluded. Subjects underwent EBCT scanning, oral glucose tolerance testing, and CHD risk factor assessment. PCOS women had significantly higher levels of serum total and low density lipoprotein cholesterol and testosterone levels than matched controls. PCOS and control women were obese and had a greater mean BMI than community-dwelling women (33 kg/m(2) for PCOS vs. 31 kg/m(2) for control; P < 0.001). CAC was more prevalent in PCOS women (39%) than in matched controls (21%; odds ratio, 2.4; P = 0.05) or community-dwelling women (9.9%; odds ratio, 5.9; P < 0.001). BMI, waist circumference, and total and low density lipoprotein cholesterol levels predicted CAC prevalence after adjustment for BMI. CAC is more prevalent in PCOS women than in obese or nonobese women of similar age. PCOS women are at increased risk for atherosclerosis and should be targeted for primary prevention of CHD.
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Cites
Prediction of coronary heart disease using risk factor categories
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CLINICAL ASSESSMENT OF BODY HAIR GROWTH IN WOMEN
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Self-citationPrevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome.
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“Sixty percent of women with PCOS in the United States are obese (4), with a central body fat distribution pattern described as visceral obesity.”
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Cited by
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Metadata
- Authors
- Christian, R. C., Dumesic, D. A., Behrenbeck, T., Oberg, A. L., Sheedy, P. F., & Fitzpatrick, L. A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2003-06
- Volume
- 88
- Issue
- 6
- Pages
- 2562-2568
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1999757775
- Cited by
- 400
- References
- 31
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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