Cited by 1,976Ovarian function and disordersEndometriosis Research and TreatmentGenetic and Kidney Cyst Diseases

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

Open access
Fauser, Bart C.J.M., Tarlatzis, Basil C., Rebar, Robert W., Legro, Richard S., Balen, Adam H., Lobo, Roger, Carmina, Enrico, Chang, Jeffrey +11 more·2012·Fertility and Sterility

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRM sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008), respectively. The present third PCOS consensus report summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk. Additional, comprehensive background information is provided separately in an extended online publication.

Integrity signals

Registry

Crossref · 10.1016/j.fertnstert.2011.09.024

Cites

326 of 326 references verified0 citation errors · 0 not checkable

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  • Metabolic and endocrine derangements of PCOS contribute to making women with PCOS more prone to develop metabolic syndrome, type 2 diabetes mellitus, and infertility.

    “Metabolic and endocrine derangements of PCOS both contribute to making women with PCOS more prone to develop metabolic syndrome, type 2 diabetes mellitus, and infertility [9,10,11].”
  • With one published exception, current definitions of polycystic ovary syndrome in adolescent or adult women do not include insulin resistance or hyperinsulinemia as a diagnostic criterion.

    “With the exception of one published recommendation, none of the current definitions of PCOS in adolescent or adult women include insulin resistance/hyperinsulinemia as a diagnostic criterion [1, 10-12, 18, 19, 112]”
  • Hyperinsulinemia is believed to worsen hyperandrogenism and the reproductive and metabolic manifestations of polycystic ovary syndrome in adolescents.

    “Hyperinsulinemia is believed to exacerbate the hyperandrogenism and the reproductive and metabolic manifestations of PCOS in adolescents.”
  • Insulin resistance and hyperinsulinemia are intrinsic to polycystic ovary syndrome in adults and adolescents, whether lean or obese.

    “Insulin resistance and hyperinsulinemia are intrinsic to PCOS in adults and adolescents, lean or obese.”

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Authors
Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., Boivin, J., Petraglia, F., Wijeyeratne, C. N., Norman, R. J., Dunaif, A., Franks, S., Wild, R. A., Dumesic, D., & Barnhart, K.
Affiliations
  • University Medical Center Utrecht (NL)
  • University of Alabama at Birmingham (US)
  • Pennsylvania State University (US)
  • Leeds Teaching Hospitals NHS Trust (GB)
  • Columbia University (US)
  • University of Palermo (IT)
  • University of California San Diego (US)
  • Erasmus MC (NL)
  • Cardiff University (GB)
  • University of Siena (IT)
  • University of Colombo (LK)
  • The University of Adelaide (AU)
  • Northwestern University (US)
  • Imperial College London (GB)
  • University of California, Los Angeles (US)
  • University of Pennsylvania (US)
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
2012-01
Volume
97
Issue
1
Pages
28-38.e25
ISSN
0015-0282 (ISSN-L)
OpenAlex
W2114250987
Cited by
1,976
References
326
Citations by year
2026: 44 · 2025: 93 · 2024: 114 · 2023: 146 · 2022: 152 · 2021: 143 · 2020: 116 · 2019: 139 · 2018: 358 · 2017: 160 · 2016: 110 · 2015: 127 · 2014: 133 · 2013: 93 · 2012: 44
FWCI
97.18
Type
journal article
Language
en
Open access
Locations
  • Fertility and Sterility (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
  • Florence Research (University of Florence) (submittedVersion)
  • Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
  • Use Siena air (University of Siena) (submittedVersion)
Funders
National Heart, Lung, and Blood Institute
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
Keywords
polycystic ovary syndrome, women's health, PCOS diagnosis, adolescent PCOS, hirsutism, acne, contraception, menstrual irregularity, quality of life, ethnicity, pregnancy complications, cardiovascular health, cancer risk
MeSH terms
Cardiovascular Diseases, Female, Humans, Infertility, Female, Metabolic Diseases, Neoplasms, Polycystic Ovary Syndrome, Pregnancy, Pregnancy Complications, Risk Factors, Consensus

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