Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Open accessAbstract
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in females, with a high prevalence. The etiology of this heterogeneous condition remains obscure, and its phenotype expression varies. Two widely cited previous ESHRE/ASRM sponsored PCOS consensus workshops focused on diagnosis (published in 2004) and infertility management (published in 2008), respectively. The present third PCOS consensus report summarizes current knowledge and identifies knowledge gaps regarding various women's health aspects of PCOS. Relevant topics addressed-all dealt with in a systematic fashion-include adolescence, hirsutism and acne, contraception, menstrual cycle abnormalities, quality of life, ethnicity, pregnancy complications, long-term metabolic and cardiovascular health, and finally cancer risk. Additional, comprehensive background information is provided separately in an extended online publication.
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Metabolic and endocrine derangements of PCOS contribute to making women with PCOS more prone to develop metabolic syndrome, type 2 diabetes mellitus, and infertility.
“Metabolic and endocrine derangements of PCOS both contribute to making women with PCOS more prone to develop metabolic syndrome, type 2 diabetes mellitus, and infertility [9,10,11].”
From Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS) (2019) · cites this paper as [10]
With one published exception, current definitions of polycystic ovary syndrome in adolescent or adult women do not include insulin resistance or hyperinsulinemia as a diagnostic criterion.
“With the exception of one published recommendation, none of the current definitions of PCOS in adolescent or adult women include insulin resistance/hyperinsulinemia as a diagnostic criterion [1, 10-12, 18, 19, 112]”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [1]
Hyperinsulinemia is believed to worsen hyperandrogenism and the reproductive and metabolic manifestations of polycystic ovary syndrome in adolescents.
“Hyperinsulinemia is believed to exacerbate the hyperandrogenism and the reproductive and metabolic manifestations of PCOS in adolescents.”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [1]
Insulin resistance and hyperinsulinemia are intrinsic to polycystic ovary syndrome in adults and adolescents, whether lean or obese.
“Insulin resistance and hyperinsulinemia are intrinsic to PCOS in adults and adolescents, lean or obese.”
From The Diagnosis of Polycystic Ovary Syndrome during Adolescence (2015) · cites this paper as [1]
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“Background Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by dysfunction of gonadal axis and systemic nerve endocrine metabolic network [1], with a prevalence of up to 10% in women of reproductive age [2,3].”
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An Update on Contraception in Polycystic Ovary Syndrome
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“Several metabolic abnormalities (such as obesity and increased prevalence of risk factors for cardiovascular disease and diabetes) are closely associated with PCOS, and lifelong medical care is required to manage PCOS symptoms and mitigate long-term health complications [6].”
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Aerobic exercise improves cardiac autonomic modulation in women with polycystic ovary syndrome
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Psychological experiences of adolescent girls with polycystic ovary syndrome: A qualitative study
Noroozi, M., Ekramzadeh, M., Hajivandi, L., & Mostafavi, F. (2020) · Iranian Journal of Nursing and Midwifery Research · doi:10.4103/ijnmr.ijnmr_276_19 · Cited by 25 · see citing works
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Neuronal androgen receptor: molecular gateway to polycystic ovary syndrome
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- Authors
- Fauser, B. C. J. M., Tarlatzis, B. C., Rebar, R. W., Legro, R. S., Balen, A. H., Lobo, R., Carmina, E., Chang, J., Yildiz, B. O., Laven, J. S. E., Boivin, J., Petraglia, F., Wijeyeratne, C. N., Norman, R. J., Dunaif, A., Franks, S., Wild, R. A., Dumesic, D., & Barnhart, K.
- Affiliations
- University Medical Center Utrecht (NL)
- University of Alabama at Birmingham (US)
- Pennsylvania State University (US)
- Leeds Teaching Hospitals NHS Trust (GB)
- Columbia University (US)
- University of Palermo (IT)
- University of California San Diego (US)
- Erasmus MC (NL)
- Cardiff University (GB)
- University of Siena (IT)
- University of Colombo (LK)
- The University of Adelaide (AU)
- Northwestern University (US)
- Imperial College London (GB)
- University of California, Los Angeles (US)
- University of Pennsylvania (US)
- ORCID
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 97
- Issue
- 1
- Pages
- 28-38.e25
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2114250987
- Cited by
- 1,976
- References
- 326
- Citations by year
- 2026: 44 · 2025: 93 · 2024: 114 · 2023: 146 · 2022: 152 · 2021: 143 · 2020: 116 · 2019: 139 · 2018: 358 · 2017: 160 · 2016: 110 · 2015: 127 · 2014: 133 · 2013: 93 · 2012: 44
- FWCI
- 97.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Florence Research (University of Florence) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Use Siena air (University of Siena) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- polycystic ovary syndrome, women's health, PCOS diagnosis, adolescent PCOS, hirsutism, acne, contraception, menstrual irregularity, quality of life, ethnicity, pregnancy complications, cardiovascular health, cancer risk
- MeSH terms
- Cardiovascular Diseases, Female, Humans, Infertility, Female, Metabolic Diseases, Neoplasms, Polycystic Ovary Syndrome, Pregnancy, Pregnancy Complications, Risk Factors, Consensus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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