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Cited by 83Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsHypertrophic osteoarthropathy and related conditions

Acromegalic Axial Arthropathy: A Clinical Case-Control Study

Scarpa, Raffaele, De Brasi, Davide, Pivonello, Rosario, Marzullo, Paolo, Manguso, Francesco, Sodano, Antonio, Oriente, Pasquale, Lombardi, Gaetano +1 more·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031283
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Abstract

Arthropathy is the major cause of morbidity in acromegaly. To feature the spinal involvement, 54 patients with active acromegaly (27 men, 27 women; age range, 21-69 yr) and 54 sex-, age-, and body mass index-matched healthy controls were enrolled in this observational analytical prospective case-control study. A questionnaire to describe onset, duration, and severity of articular symptoms; rheumatological examination, including vertebral and chest mobility, Schober test, thorax expansion, and axial radiological study; and IGF-I, GH, insulin, and glucose level measurement (baseline and after an oral glucose tolerance test) was used to investigate the prevalence of arthropathy and correlate these findings with hormonal parameters. Axial arthropathy was found in 28 patients (52%) and 12 controls (22%; chi(2) = 8.9; P = 0.003). In detail, spinal mobility was reduced in 30 patients (56%) and 10 controls (18%; chi(2) = 14.3; P < 0.0001), thoracic cage was involved in six patients (11%), alterations of spinal profile were observed in 37 patients (68%) and 15 controls (28%; chi(2) = 16.3; P < 0.0001), and increased L2 vertebra diameters were observed in 34 patients (63%) and none of the controls (chi(2) = 46.7; P < 0.0001). Narrowing and widening of L2-L3 disk space were found in 20 (37%) and seven (13%) patients, respectively. Features of diffuse idiopathic skeletal hyperostosis (DISH) were found in 11 patients (20%) and none of the controls (chi(2) = 10.1; P < 0.001). Disease durat…

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  • In patients with acromegaly, changes in bone size and density and arthropathy are common problems.

    “In patients with acromegaly changes in bone size and density and arthropathy are common problems [31–33].”

    From Pituitary Disorders and Osteoporosis (2015) · cites this paper as [32]

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Authors
Scarpa, R., De Brasi, D., Pivonello, R., Marzullo, P., Manguso, F., Sodano, A., Oriente, P., Lombardi, G., & Colao, A.
Affiliations
  • Federico II University Hospital (IT)
  • University of Naples Federico II (IT)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-02
Volume
89
Issue
2
Pages
598-603
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031283
OpenAlex
W2128596172
Cited by
83
References
29
Citations by year
2026: 2 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 10 · 2012: 4
FWCI
2.75
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Rheumatology › Hypertrophic osteoarthropathy and related conditions
Keywords
acromegaly, spinal involvement, diffuse idiopathic skeletal hyperostosis, spinal mobility, thoracic cage, L2 vertebra, intervertebral disc space, insulin-like growth factor I, growth hormone excess, disease duration, glucose tolerance, radiographic findings, articular symptoms, lumbar spine mobility, vertebral body height
MeSH terms
Acromegaly, Adult, Aged, Hyperostosis, Diffuse Idiopathic Skeletal, Female, Humans, Male, Middle Aged, Prospective Studies, Radiography, Severity of Illness Index, Spinal Diseases, Spine, Prevalence, Case-Control Studies

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