The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Relationship between Serum Resistin Concentrations and Insulin Resistance in Nonobese, Obese, and Obese Diabetic Subjects
Abstract
Early reports suggested that resistin is associated with obesity and insulin resistance in rodents. However, subsequent studies have not supported these findings. To our knowledge, the present study is the first assessment in human subjects of serum resistin and insulin sensitivity by the insulin clamp technique. Thirty-eight nonobese subjects [age, 23 ± 4 yr; body mass index (BMI), 25.4 ± 4.3 kg/m2], 12 obese subjects (age, 54 ± 8 yr; BMI, 33.0 ± 2.5 kg/m2), and 22 obese subjects with type 2 diabetes (age, 59 ± 7 yr; BMI, 34.0 ± 2.4 kg/m2) were studied. Serum resistin concentrations were not different among nonobese (4.1 ± 1.7 ng/ml), obese (4.2 ± 1.6 ng/ml), and obese diabetic subjects (3.7 ± 1.2 ng/ml), and were not significantly correlated to glucose disposal rate during a hyperinsulinemic glucose clamp across groups. Serum resistin was, however, inversely related to insulin sensitivity in nonobese subjects only (r = −0.35; P = 0.05), although this association was lost after adjusting for percent body fat. Serum resistin was not related to percent fat, BMI, or fat cell size. A strong correlation was observed between serum resistin and resistin mRNA expression from abdominal sc adipose tissue in a separate group of obese subjects (r = 0.62; P < 0.01; n = 56). Although the exact function of resistin is unknown, we demonstrated only a weak relationship between resistin and insulin sensitivity in nonobese subjects, indicating that resistin is unlikely to be a major link between obesity and insulin resistance in humans.
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The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
Weyer, C., Foley, J. E., Bogardus, C., Tataranni, P. A., & Pratley, R. E. (2000) · Diabetologia · doi:10.1007/s001250051560 · Cited by 799
The Look AHEAD Research Group (2003) · Controlled Clinical Trials · doi:10.1016/s0197-2456(03)00064-3 · Cited by 767
Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A., Henzel, W., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., et al. (2000) · The EMBO Journal · doi:10.1093/emboj/19.15.4046 · Cited by 661
Jacob, S., Machann, J., Rett, K., Brechtel, K., Volk, A., Renn, W., Maerker, E., Matthaei, S., Schick, F., Claussen, C. D., et al. (1999) · Diabetes · doi:10.2337/diabetes.48.5.1113 · Cited by 643
Smith, S. R., Lovejoy, J. C., Greenway, F., Ryan, D., deJonge, L., de la Bretonne, J., Volafova, J., & Bray, G. A. (2001) · Metabolism · doi:10.1053/meta.2001.21693 · Cited by 596
Self-citationA Cysteine-rich Adipose Tissue-specific Secretory Factor Inhibits Adipocyte Differentiation
Kim, K.-H., Lee, K., Moon, Y. S., & Sul, H. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100028200 · Cited by 583
Havel, P. J. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00008 · Cited by 575
Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., & O’Rahilly, S. (2001) · Diabetes · doi:10.2337/diabetes.50.10.2199 · Cited by 572
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Adipokines in inflammation and metabolic disease
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Rasouli, N., & Kern, P. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1613 · Cited by 743
Larson-Meyer, D. E., Heilbronn, L. K., Redman, L. M., Newcomer, B. R., Frisard, M. I., Anton, S., Smith, S. R., Alfonso, A., Ravussin, E., & the Pennington CALERIE Team (2006) · Diabetes Care · doi:10.2337/dc05-2565 · Cited by 504
Self-citationThe role of resistin as a regulator of inflammation: Implications for various human pathologies
Filková, M., Haluzík, M., Gay, S., & Šenolt, L. (2009) · Clinical Immunology · doi:10.1016/j.clim.2009.07.013 · Cited by 451
Insulin resistance in chronic kidney disease: a systematic review
Spoto, B., Pisano, A., & Zoccali, C. (2016) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00340.2016 · Cited by 450
Metadata
- Authors
- Heilbronn, L. K., Rood, J., Janderova, L., Albu, J. B., Kelley, D. E., Ravussin, E., & Smith, S. R.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-04-01
- Volume
- 89
- Issue
- 4
- Pages
- 1844-1848
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1988800094
- Cited by
- 307
- References
- 26
- FWCI
- 18.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Heilbronn, L. K., Rood, J., Janderova, L., Albu, J. B., Kelley, D. E., Ravussin, E., & Smith, S. R. (2004). Relationship between Serum Resistin Concentrations and Insulin Resistance in Nonobese, Obese, and Obese Diabetic Subjects. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2003-031410
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