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Cited by 593Hormonal and reproductive studiesAdrenal Hormones and DisordersMenopause: Health Impacts and Treatments

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Prevalence and Incidence of Androgen Deficiency in Middle-Aged and Older Men: Estimates from the Massachusetts Male Aging Study

Araujo, Andre B., O’Donnell, Amy B., Brambilla, Donald J., Simpson, William B., Longcope, Christopher, Matsumoto, Alvin M., McKinlay, John B.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2003-031719
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Abstract

Little is known about the descriptive epidemiology of androgen deficiency. In this study, we sought to address this issue by providing estimates of the crude and age-specific prevalence and incidence rates of androgen deficiency in a randomly sampled population-based cohort of middle-aged and older men. Data on androgen deficiency (defined using both signs/symptoms plus total and calculated free testosterone) were available for n = 1691 (baseline) and n = 1087 (follow-up) men from the Massachusetts Male Aging Study. Crude and age-specific prevalence and incidence rates were calculated. Based on these estimates, projections for the number of cases of androgen deficiency in the 40- to 69-yr-old U.S. male population were computed. Estimates of the crude prevalence of androgen deficiency at baseline and follow-up were 6.0 and 12.3%, respectively. Prevalence increased significantly with age. From baseline age-specific prevalence data, it is estimated that there are approximately 2.4 million 40- to 69-yr-old U.S. males with androgen deficiency. The crude incidence rate of androgen deficiency was 12.3 per 1,000 person-years, and the rate increased significantly (P < 0.0001) with age. Based on these incidence data, we can expect approximately 481,000 new cases of androgen deficiency per year in U.S. men 40-69 yr old.

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  1. Margolin, 1988, Test for trend in proportions, In: Klotz S, Johnson NL, eds. Encyclopedia of statistical sciences. New York: John Wiley & Sons, Inc.;, 334

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Metadata

Authors
Araujo, A. B., O’Donnell, A. B., Brambilla, D. J., Simpson, W. B., Longcope, C., Matsumoto, A. M., & McKinlay, J. B.
Affiliations
  • New England Research Institutes (A.B.A., A.B.O., D.J.B., W.B.S., J.B.M.), Watertown, Massachusetts 02472
  • New England Research Institutes (US)
  • University of Massachusetts Chan Medical School (US)
  • University of Washington (US)
Corresponding author
McKinlay, John B.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-12-01
Volume
89
Issue
12
Pages
5920-5926
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2003-031719
OpenAlex
W2051191691
Cited by
591
References
22
Citations by year
2026: 9 · 2025: 21 · 2024: 19 · 2023: 13 · 2022: 31 · 2021: 19 · 2020: 23 · 2019: 20 · 2018: 24 · 2017: 35 · 2016: 34 · 2015: 40 · 2014: 33 · 2013: 35 · 2012: 39
FWCI
14.67
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (7p01ag004673-05)
  • National Institute on Aging (AG 04673)
  • National Cancer Institute (R01-CA770403)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 51345, R01DK044995, DK44995, R01DK051345)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords
androgen deficiency, hypogonadism, prevalence, incidence, middle-aged men, older men, free testosterone, age-specific prevalence, case projections, Massachusetts Male Aging Study
MeSH terms
Adult, Aged, Aging, Androgens, Follow-Up Studies, Humans, Male, Massachusetts, Metabolic Diseases, Middle Aged, Testosterone, Cohort Studies, Incidence, Prevalence

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