Proteinuric Nephropathy in Acquired and Congenital Generalized Lipodystrophy: Baseline Characteristics and Course during Recombinant Leptin Therapy

Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency

Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998 · see citing works

Recombinant Leptin for Weight Loss in Obese and Lean Adults: A Randomized, Controlled, Dose-Escalation Trial

Heymsfield, S. B., Greenberg, A. S., Fujioka, K., Dixon, R. M., Kushner, R., Hunt, T., Lubina, J. A., Patane, J., Self, B., Hunt, P., et al. (1999) · JAMA · doi:10.1001/jama.282.16.1568 · Cited by 1,422 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,359 · see citing works

Leptin-Replacement Therapy for Lipodystrophy

Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247 · see citing works

Update on the 1987 Task Force Report on High Blood Pressure in Children and Adlescents : A Work Group Report from the National High Blood Pressure Education Program

Lung (1996) · PEDIATRICS · Cited by 867 · see citing works

Identification of the gene altered in Berardinelli–Seip congenital lipodystrophy on chromosome 11q13

Magré, J., Délepine, M., Khallouf, E., Gedde‐Dahl, T., Maldergem, L. V., Sobel, E. M., Papp, J. C., Meier, M., Mégarbané, A., BSCL Working Group, et al. (2001) · Nature Genetics · doi:10.1038/ng585 · Cited by 755 · see citing works

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

Petersen (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215001 · Cited by 622 · see citing works

AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34

Agarwal, A. K., Oral, E. A., de Almeida, S., Akkoç, N., Taylor, S. I., Bowcock, A. M., Barnes, R. I., & Garg, A. (2002) · Nature Genetics · doi:10.1038/ng880 · Cited by 522 · see citing works

Radioimmunoassay of leptin in human plasma

Ma, Z., Gingerich, R. L., Santiago, J. V., Klein, S., Smith, C. H., & Landt, M. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.6.942 · Cited by 493 · see citing works

Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells: Potential role in glomerulosclerosis

Wolf, G., Hamann, A., Han, D. C., Helmchen, U. M., Thaiss, F., Ziyadeh, F. N., & Stahl, R. A. K. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00626.x · Cited by 391 · see citing works

Update on the 1987 Task Force Report on High Blood Pressure in Children and Adolescents: a working group report from the National High Blood Pressure Education Program. National High Blood Pressure Education Program Working Group on Hypertension Control in Children and Adolescents.

(1996) · PubMed · Cited by 377 · see citing works

Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses

Sanna, V., Giacomo, A. D., Cava, A. L., Lechler, R. I., Fontana, S., Zappacosta, S., & Matarese, G. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16721 · Cited by 360 · see citing works

Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses

Sanna, V., Giacomo, A. D., Cava, A. L., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316721 · Cited by 317 · see citing works

THE SYNDROMES OF TOTAL LIPODYSTROPHY AND OF PARTIAL LIPODYSTROPHY

Senior, B., & Gellis, S. S. (1964) · PEDIATRICS · doi:10.1542/peds.33.4.593 · Cited by 296 · see citing works

LIPODYSTROPHY AND HEPATOMEGALY WITH DIABETES, LIPÆMIA, AND OTHER METABOLIC DISTURBANCES

Lawrence, R. D. (1946) · The Lancet · doi:10.1016/s0140-6736(46)90528-4 · Cited by 287 · see citing works

Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice.

Clouthier, D. E., Comerford, S. A., & Hammer, R. E. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119815 · Cited by 282 · see citing works

The Complement Abnormalities of Lipodystrophy

Sissons, J. G. P., West, R. J., Fallows, J., Williams, D. G., Boucher, B. J., Amos, N., & Peters, D. K. (1976) · New England Journal of Medicine · doi:10.1056/nejm197602262940902 · Cited by 269 · see citing works

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215693 · Cited by 183 · see citing works

MESANGIOCAPILLARY NEPHRITIS, PARTIAL LIPODYSTROPHY, AND HYPOCOMPLEMENTÆMIA

Peters, D. K., CHARLESWORTH, J. A., Sissons, J. G. P., Williams, D. G., Boulton‐Jones, J. M., Evans, D. J., KOURILSKY, O., & Morel-Marogér, L. (1973) · The Lancet · doi:10.1016/s0140-6736(73)92351-9 · Cited by 156 · see citing works

Effect of Leptin Replacement on Pituitary Hormone Regulation in Patients with Severe Lipodystrophy

Oral, E. A., Ruiz, E., Andewelt, A., Sebring, N., Wagner, A. J., Depaoli, A. M., & Gorden, P. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.7.8591 · Cited by 129 · see citing works

Effect of Leptin Replacement on Intrahepatic and Intramyocellular Lipid Content in Patients With Generalized Lipodystrophy

Simha, V., Szczepaniak, L. S., Wagner, A. J., DePaoli, A. M., & Garg, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.30 · Cited by 123 · see citing works

Changes in body composition in patients with severe lipodystrophy after leptin replacement therapy

Moran, S. A., Patten, N., Young, J. R., Cochran, E., Sebring, N., Reynolds, J., Premkumar, A., Depaoli, A. M., Skarulis, M. C., Oral, E. A., et al. (2004) · Metabolism · doi:10.1016/j.metabol.2003.10.019 · Cited by 96 · see citing works

Renal Disease in Partial Lipodystrophy

Eisinger, A. J., Shortland, J. R., & Moorhead, P. J. (1972) · QJM · doi:10.1093/oxfordjournals.qjmed.a067312 · Cited by 70 · see citing works

Leptin-Replacement Therapy in Lipodystrophy

Wolfsdorf, J. I., Sadeghi‐Nejad, A., & Senior, B. (2002) · New England Journal of Medicine · doi:10.1056/nejm200206203462515 · Cited by 61 · see citing works

Partial lipodystrophy, C3 nephritic factor and clinically inapparent mesangiocapillary glomerulonephritis

Bennett, W. M., Bardana, E. J., Wuepper, K. D., Houghton, D. C., Border, W. A., Götze, O., & Schreiber, R. D. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90879-8 · Cited by 50 · see citing works

Effect of subcutaneous leptin replacement therapy on bone metabolism in patients with generalized lipodystrophy

Simha, V., Zerwekh, J. E., Sakhaee, K., & Garg, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020792 · Cited by 42 · see citing works

Lipoatrophic Diabetes and Other Related Syndromes

Oral, E. A. (2003) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1021827520301 · Cited by 29 · see citing works

PARTIAL LIPODYSTROPHY AND CHRONIC HYPOCOMPLEMENTEMIC GLOMERULONEPHRITIS

Ljunghall, S., Fjellström, K., & Wibell, L. B. (1974) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1974.tb08177.x · Cited by 24 · see citing works

Successful Renal Transplantation in a Patient with Congenital Generalized Lipodystrophy: A Case Report

McNally, M., Mannon, R. B., Javor, E. D., Swanson, S. J., Hale, D. A., Görden, P., & Kirk, A. D. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00358.x · Cited by 21 · see citing works

Membranoproliferative glomerulonephritis with partial lipodystrophy

Reichel, W., K�bberling, J., Fischbach, H., & Scheler, F. (1976) · Journal of Molecular Medicine · doi:10.1007/bf01468772 · Cited by 19 · see citing works

Cephalothoracic Lipodystrophy with Hypocomplementemic Renal Disease: Discordance in Identical Twin Sisters*

Bier, D. M., O’Donnell, J. J., & Kaplan, S. L. (1978) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-46-5-800 · Cited by 18 · see citing works

Total lipodystrophy with heart failure and renal failure: Report of a case.

ISHII, J., Abe, M., Kubo, M., Sumimoto, T., Hamada, M., Hiwada, K., Kokubu, T., & Osawa, G. (1989) · Japanese Journal of Medicine · doi:10.2169/internalmedicine1962.28.534 · Cited by 15 · see citing works

RENAL TRANSPLANTATION IN A PATIENT WITH LIPOATROPHIC DIABETES A CASE REPORT

Casali, R. E., Resnick, J. S., Goetz, F. C., Simmons, R. L., Najarian, J. S., & Kjellstrand, C. M. (1978) · Transplantation · doi:10.1097/00007890-197809000-00009 · Cited by 14 · see citing works

The Renal Lesion Associated with Total Lipodystrophy

Saito, I., Saruta, T., IYORI, S., & Sakaguchi, H. (1977) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1977.tb00288.x · Cited by 12 · see citing works

Membranoproliferative Glomerulonephritis, Type II and Partial Lipodystrophy in an Adult

Pollock, J., Wood, B., & Kelly, J. P. (1986) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(86)80041-5 · Cited by 10 · see citing works

The pregnant patient with partial lipodystrophy developing acute renal failure - onset of de novo membranoproliferative glomerulonephritis

Demetriou, K. (1998) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/13.8.2121 · Cited by 10 · see citing works

Partial lipodystrophy and renal disease

Cahill, J., Waldron, S., O'Neill, G., & Duffy, B. S. (1983) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf02958708 · Cited by 4 · see citing works

Partial lipodystrophy, C3 nephritic factor and clinically inapparent mesangiocapillary glomerulonephritis

(1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90903-2 · Cited by 2 · see citing works

Inflammation and the pathogenesis of diabetic nephropathy

Wada, J., & Makino, H. (2012) · Clinical Science · doi:10.1042/cs20120198 · Cited by 776 · see citing works

The Diagnosis and Management of Lipodystrophy Syndromes: A Multi-Society Practice Guideline

Brown, R. J., Araújo‐Vilar, D., Cheung, P. T., Dunger, D. B., Garg, A., Jack, M., Mungai, L., Oral, E. A., Patni, N., Rother, K. I., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2466 · Cited by 532 · see citing works

Regulation of Renal Lipid Metabolism, Lipid Accumulation, and Glomerulosclerosis in FVB db/db Mice With Type 2 Diabetes

Wang, Z., Jiang, T., Li, J., Proctor, G., McManaman, J. L., Lucia, S. M., Chua, S. C., & Levi, M. (2005) · Diabetes · doi:10.2337/diabetes.54.8.2328 · Cited by 304 · see citing works

Regulation of Renal Fatty Acid and Cholesterol Metabolism, Inflammation, and Fibrosis in Akita and OVE26 Mice With Type 1 Diabetes

Proctor, G., Jiang, T., Iwahashi, M., Wang, Z., Li, J., & Levi, M. (2006) · Diabetes · doi:10.2337/db05-0603 · Cited by 303 · see citing works

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

Patni, N., & Garg, A. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.123 · Cited by 262 · see citing works

Lipodystrophy: pathophysiology and advances in treatment

Fiorenza, C. G., Chou, S. H.-H., & Mantzoros, C. S. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.199 · Cited by 255 · see citing works

Efficacy and Safety of Leptin-Replacement Therapy and Possible Mechanisms of Leptin Actions in Patients with Generalized Lipodystrophy

Ebihara, K., Kusakabe, T., Hirata, M., Masuzaki, H., Miyanaga, F., Kobayashi, N., Tanaka, T., Chusho, H., Miyazawa, T., Hayashi, T., et al. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1546 · Cited by 230 · see citing works

Long-Term Efficacy of Leptin Replacement in Patients With Generalized Lipodystrophy

Javor, E. D., Cochran, E. K., Musso, C., Young, J. R., DePaoli, A. M., & Gorden, P. (2005) · Diabetes · doi:10.2337/diabetes.54.7.1994 · Cited by 226 · see citing works

Nephropathy in males and females with Fabry disease: cross-sectional description of patients before treatment with enzyme replacement therapy

Ortíz, A., Oliveira, J. P., Waldek, S., Warnock, D. G., Cianciaruso, B., Wanner, C., & on behalf of the Fabry Registry (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfm848 · Cited by 221 · see citing works

Role of leptin in blood pressure regulation and arterial hypertension

Bełtowski, J. (2006) · Journal of Hypertension · doi:10.1097/01.hjh.0000222743.06584.66 · Cited by 214 · see citing works

Side Effects of Cytokines Approved for Therapy

Baldo, B. A. (2014) · Drug Safety · doi:10.1007/s40264-014-0226-z · Cited by 189 · see citing works

Partial and Generalized Lipodystrophy: Comparison of Baseline Characteristics and Response to Metreleptin

Diker‐Cohen, T., Cochran, E. K., Görden, P., & Brown, R. J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4491 · Cited by 180 · see citing works

Efficacy of leptin therapy in the different forms of human lipodystrophy

Chong, A. Y., Lupsa, B. C., Cochran, E. K., & Görden, P. (2009) · Diabetologia · doi:10.1007/s00125-009-1502-9 · Cited by 175 · see citing works

Genetic Modulation of Senescent Phenotypes in Homo sapiens

Martin, G. M. (2005) · Cell · doi:10.1016/j.cell.2005.01.031 · Cited by 171 · see citing works

Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy

Lennon, R., Pons, D., Sabin, M. A., Wei, C., Hamilton-Shield, J. P., Coward, R. J., Tavaré, J. M., Mathieson, P. W., Saleem, M. A., & Welsh, G. I. (2009) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfp302 · Cited by 148 · see citing works

Extreme phenotypic diversity and nonpenetrance in families with the LMNA gene mutation R644C

Rankin, J., Auer‐Grumbach, M., Bagg, W., Colclough, K., Dương, N. T., Fenton‐May, J., Hattersley, A. T., Hudson, J. A., Jardine, P. E., Josifova, D. J., et al. (2008) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.32331 · Cited by 109 · see citing works

Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey

Akıncı, B., Önay, H., Demir, T., Özen, S., Kayserili, H., Akıncı, G., Nur, B. G., Tüysüz, B., Özbek, M. N., Güngör, Â., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-1005 · Cited by 99 · see citing works

Comparison of Efficacy and Safety of Leptin Replacement Therapy in Moderately and Severely Hypoleptinemic Patients with Familial Partial Lipodystrophy of the Dunnigan Variety

Simha, V., Subramanyam, L., Szczepaniak, L. S., Quittner, C., ADAMS-HUET, B. A., Snell, P. G., & Garg, A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2229 · Cited by 96 · see citing works

Clinical Classification and Treatment of Congenital and Acquired Lipodystrophy

Chan, J. L., & Oral, E. A. (2010) · Endocrine Practice · doi:10.4158/ep09154.ra · Cited by 93 · see citing works

Complement Abnormalities in Acquired Lipodystrophy Revisited

Savage, D. B., Semple, R. K., Clatworthy, M. R., Lyons, P., Morgan, B. P., Cochran, E. K., Görden, P., Raymond‐Barker, P., Murgatroyd, P. R., Adams, C., et al. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1703 · Cited by 87 · see citing works

Type 1 Diabetes Associated with Acquired Generalized Lipodystrophy and Insulin Resistance: The Effect of Long-Term Leptin Therapy

Park, J. Y., Chong, A. Y., Cochran, E. K., Kleiner, D. E., Haller, M. J., Schatz, D., & Görden, P. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1856 · Cited by 79 · see citing works

Rationale for Leptin-Replacement Therapy for Severe Lipodystrophy

Oral, E. A., & Chan, J. L. (2010) · Endocrine Practice · doi:10.4158/ep09155.ra · Cited by 77 · see citing works

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy

Meehan, C. A., Cochran, E. K., Kassai, A., Brown, R. J., & Görden, P. (2015) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2016.1096772 · Cited by 73 · see citing works

Leptin Replacement Therapy Modulates Circulating Lymphocyte Subsets and Cytokine Responsiveness in Severe Lipodystrophy

Oral, E. A., Javor, E. D., Ding, L., Uzel, G., Cochran, E. K., Young, J. R., DePaoli, A. M., Holland, S. M., & Görden, P. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1220 · Cited by 67 · see citing works

Leptin in congenital and HIV-associated lipodystrophy

Tsoukas, M. A., Farr, O. M., & Mantzoros, C. S. (2014) · Metabolism · doi:10.1016/j.metabol.2014.07.017 · Cited by 58 · see citing works

Spectrum of Renal Diseases Associated with Extreme Forms of Insulin Resistance

Musso, C., Javor, E. D., Cochran, E. K., Balow, J. E., & Görden, P. (2006) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01271005 · Cited by 56 · see citing works

Secondary Glomerular Disease

Appel, G. B., Radhakrishnan, J., & D’Agati, V. D. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6193-9.10032-6 · Cited by 56 · see citing works

Lipodystrophies: adipose tissue disorders with severe metabolic implications

Cortés, V., & Fernández‐Galilea, M. (2015) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-015-0404-1 · Cited by 53 · see citing works

Lipodystrophy for the Diabetologist—What to Look For

Patni, N., & Garg, A. (2022) · Current Diabetes Reports · doi:10.1007/s11892-022-01485-w · Cited by 52 · see citing works

Diagnostic strategies and clinical management of lipodystrophy

Foss‐Freitas, M. C., Akıncı, B., Luo, Y., Stratton, A., & Oral, E. A. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2020.1735360 · Cited by 51 · see citing works

Adipokines in the HIV/HAART-associated lipodystrophy syndrome

Paruthi, J., Gill, N., & Mantzoros, C. S. (2013) · Metabolism · doi:10.1016/j.metabol.2013.04.014 · Cited by 46 · see citing works

Current Diagnosis, Treatment and Clinical Challenges in the Management of Lipodystrophy Syndromes in Children and Young People

Özen, S., Akıncı, B., & Oral, E. A. (2019) · Journal of Clinical Research in Pediatric Endocrinology · doi:10.4274/jcrpe.galenos.2019.2019.0124 · Cited by 44 · see citing works

Update on Therapeutic Options in Lipodystrophy

Akıncı, B., Meral, R., & Oral, E. A. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1100-7 · Cited by 40 · see citing works

Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

Ziegler, J., Böttcher, C., Letizia, M., Yerinde, C., Wu, H., Freise, I., Rodriguez‐Sillke, Y., Stoyanova, A. K., Kreis, M. E., Asbach, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13559-7 · Cited by 39 · see citing works

Cosegregation of Focal Segmental Glomerulosclerosis in a Family with Familial Partial Lipodystrophy due to a Mutation in LMNA

Thong, K. M., Xu, Y., Cook, J. A., Takou, A., Wagner, B. E., Kawar, B., & Ong, A. C. M. (2013) · Nephron Clinical Practice · doi:10.1159/000354716 · Cited by 38 · see citing works

Renal complications of lipodystrophy: A closer look at the natural history of kidney disease

Akıncı, B., Ünlü, Ş. M., Çelik, A., Şimşir, İ. Y., Şen, S., Nur, B. G., Keskin, F. E., Saydam, B. Ö., Kutbay, N. Ö., Yürekli, B. Ş., et al. (2018) · Clinical Endocrinology · doi:10.1111/cen.13732 · Cited by 36 · see citing works

Role of the kidney in the metabolism of apolipoprotein A-IV: influence of the type of proteinuria

Lingenhel, A., Lhotta, K., Neyer, U., Heid, I. M., Rantner, B., Kronenberg, M. F., König, P., von Eckardstein, A., Schober, M., Dieplinger, H., et al. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600178-jlr200 · Cited by 33 · see citing works

An overview of lipodystrophy and the role of the complement system

Corvillo, F., & Akıncı, B. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.05.011 · Cited by 31 · see citing works

Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives

Tchang, B. G., Shukla, A. P., & Aronne, L. J. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1052789 · Cited by 28 · see citing works

Clinical features of generalized lipodystrophy in Turkey: A cohort analysis

Şimşir, İ. Y., Tüysüz, B., Özbek, M. N., Tanrıkulu, S., Güler, M. Ç., Karhan, A. N., Öngen, Y. D., Güneş, N., Soyaltın, U. E., Altay, C., et al. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15061 · Cited by 28 · see citing works

Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice

Wang, H., Xu, P., Li, J., Liu, X., Wu, X., Fang, X., Xie, B., Huang, X., Zhou, Z., Kayoumu, A., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00180.2018 · Cited by 27 · see citing works

Renal injury in Seipin ‐deficient lipodystrophic mice and its reversal by adipose tissue transplantation or leptin administration alone: adipose tissue‐kidney crosstalk

Liu, X., Wu, X., Wang, H., Wang, S., Kong, W., Zhang, L., Liu, C., & Huang, W. Y. (2018) · The FASEB Journal · doi:10.1096/fj.201701427r · Cited by 27 · see citing works

Therapeutic use of recombinant methionyl human leptin

Vatier, C., Gautier, J., & Vigouroux, C. (2012) · Biochimie · doi:10.1016/j.biochi.2012.03.013 · Cited by 28 · see citing works

Lipid partitioning after uninephrectomy

Zhao, H., Sui, Y., He, L., Guan, J. Z., Xiao, S., Zhong, D., Xu, Q. R., & Zeng, S. (2011) · Acta Diabetologica · doi:10.1007/s00592-011-0286-9 · Cited by 25 · see citing works

A rapid action plan to improve diagnosis and management of lipodystrophy syndromes

Fourman, L. T., Lima, J. G., Simha, V., Cappa, M., Al-Yaarubi, S., Montenegro, R. M., Akıncı, B., & Santini, F. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1383318 · Cited by 24 · see citing works

Role of Seipin in Human Diseases and Experimental Animal Models

Li, Y., Yang, X., Peng, L., Xia, Q., Zhang, Y., Huang, W., Liu, T., & Jia, D. (2022) · Biomolecules · doi:10.3390/biom12060840 · Cited by 23 · see citing works

Acute leptin exposure reduces megalin expression and upregulates TGFβ1 in cultured renal proximal tubule cells

Briffa, J. F., Grinfeld, E., Mathai, M. L., Poronnik, P., McAinch, A. J., & Hryciw, D. H. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.11.024 · Cited by 24 · see citing works

Body Fat Distribution Contributes to Defining the Relationship between Insulin Resistance and Obesity in Human Diseases

Adeva‐Andany, M. M., Domínguez-Montero, A., Adeva-Contreras, L., Fernández‐Fernández, C., Carneiro-Freire, N., & González-Lucán, M. (2023) · Current Diabetes Reviews · doi:10.2174/1573399820666230816111624 · Cited by 24 · see citing works

Leptin in Relation to the Lipodystrophy-Associated Metabolic Syndrome

Mantzoros, C. S. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.3.181 · Cited by 22 · see citing works

The renal phenotype of allopurinol-treated HPRT-deficient mouse

Zennaro, C., Tonon, F., Zarattini, P., Clai, M., Corbelli, A., Carraro, M., Marchetti, M., Ronda, L., Paredi, G., Rastaldi, M. P., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173512 · Cited by 19 · see citing works

Effects of Metreleptin on Proteinuria in Patients With Lipodystrophy

Lee, H. L., Waldman, M. A., Auh, S., Balow, J. E., Cochran, E. K., Görden, P., & Brown, R. J. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00200 · Cited by 19 · see citing works

Leptin therapy in lipodystrophy

Savage, D. B., & O’Rahilly, S. (2009) · Diabetologia · doi:10.1007/s00125-009-1545-y · Cited by 19 · see citing works

Atypical Progeroid Syndrome and Partial Lipodystrophy Due to LMNA Gene p.R349W Mutation

Magno, S., Ceccarini, G., Pelosini, C., Ferrari, F., Prodam, F., Gilio, D., Maffei, M., Sessa, M. R., Barison, A., Ciccarone, A., et al. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa108 · Cited by 18 · see citing works

The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature

Chen, R., Zhang, L., Ye, W., Wen, Y.-B., Si, N., Li, H., Li, M., Li, X., & Zheng, K. (2018) · BMC Nephrology · doi:10.1186/s12882-018-0913-6 · Cited by 18 · see citing works

JUVENILE DERMATOMYOSITIS

Rider, L. G., Lindsley, C. B., & Cassidy, J. T. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4160-6581-4.10024-x · Cited by 17 · see citing works

Role of TGF-β signalling in PCOS associated focal segmental glomerulosclerosis

Bhati, M., Prabhu, Y. D., Renu, K., Vellingiri, B., Thiagarajan, P., Panda, A., Chakraborty, R., Myakala, H., & Gopalakrishnan, A. V. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.07.032 · Cited by 18 · see citing works

Histological Manifestations of Diabetic Kidney Disease and its Relationship with Insulin Resistance

Adeva‐Andany, M. M., Adeva-Contreras, L., Fernández‐Fernández, C., Carneiro-Freire, N., & Domínguez-Montero, A. (2022) · Current Diabetes Reviews · doi:10.2174/1573399818666220328145046 · Cited by 17 · see citing works

A new mutation in the CAVIN1/PTRF gene in two siblings with congenital generalized lipodystrophy type 4: case reports and review of the literature

Mancioppi, V., Daffara, T., Romanisio, M., Ceccarini, G., Pelosini, C., Santini, F., Bellone, S., Mellone, S., Baricich, A., Rabbone, I., et al. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1212729 · Cited by 16 · see citing works

Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy

Grewal, S., Gubbi, S., Fosam, A. E., Sedmak, C., Sikder, S., Talluru, H., Brown, R. J., & Muniyappa, R. (2019) · Journal of the Endocrine Society · doi:10.1210/jendso/bvz022 · Cited by 16 · see citing works

Urocortin ameliorates diabetic nephropathy in obese db/db mice

Li, X., Hu, J., Zhang, R., Sun, X., Zhang, Q., Guan, X., Chen, J., Zhu, Q., & Li, S. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.155 · Cited by 16 · see citing works

Metreleptin for metabolic disorders associated with generalized or partial lipodystrophy

Simha, V. (2014) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.894877 · Cited by 14 · see citing works

Reversal of hypertriglyceridemia in diabetic BTBR ob/ob mice does not prevent nephropathy

Attie, A., Schueler, K., Keller, M. P., Mitok, K. A., Simonett, S. P., Hudkins, K. L., Mehrotra, K., Graham, M. J., Lee, R. G., & Alpers, C. E. (2021) · Laboratory Investigation · doi:10.1038/s41374-021-00592-8 · Cited by 14 · see citing works

Complications of lipodystrophy syndromes

Akıncı, G., Güler, M. Ç., & Akıncı, B. (2021) · La Presse Médicale · doi:10.1016/j.lpm.2021.104085 · Cited by 13 · see citing works

Metreleptin Treatment in Three Patients with Generalized Lipodystrophy

Musso, C., Major, M. L., Andres, E., & Simha, V. (2016) · Clinical Medicine Insights Case Reports · doi:10.4137/ccrep.s40196 · Cited by 13 · see citing works

Congenital generalized lipodystrophy: The evaluation of clinical follow-up findings in a series of five patients with type 1 and two patients with type 4

Güneş, N., Kutlu, T., Tekant, G. T., Eroğlu, A. G., Çomunoğlu, N., Öztürk, B., Önay, H., & Tüysüz, B. (2019) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2019.103819 · Cited by 13 · see citing works

Familial partial lipodystrophy and proteinuric renal disease due to a missense c.1045C > T LMNA mutation

Fountas, A., Giotaki, Z., Dounousi, E. C., Liapis, G., Bargiota, Α., Tsatsoulis, A. A., & Tigas, S. K. (2017) · Endocrinology Diabetes and Metabolism Case Reports · doi:10.1530/edm-17-0049 · Cited by 12 · see citing works

Leptin Therapy in Patients with Lipodystrophy and Syndromic Insulin Resistance

Brown, R. J., & Görden, P. (2014) · Springer eBooks · doi:10.1007/978-3-319-09915-6_18 · Cited by 12 · see citing works

W(h)ither Metreleptin for Lipodystrophy and the Metabolic Syndrome?

Mantzoros, C. S. (2010) · Endocrine Practice · doi:10.4158/ep10038.ed · Cited by 11 · see citing works

Treatment Options for Lipodystrophy in Children

Mainieri, F., Tagi, V. M., & Chiarelli, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.879979 · Cited by 10 · see citing works

Lipodystrophy Syndromes

Tsoukas, M. A., & Mantzoros, C. S. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00037-8 · Cited by 10 · see citing works

Inflammatory diseases of the subcutaneous fat

Luzar, B., & Calonje, E. J. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-5649-2.00010-x · Cited by 10 · see citing works

Lipodystrophy Severity Score to Assess Disease Burden in Lipodystrophy

Brown, R. J., Akıncı, B., Yosef, M., Phillips, H., Khalatbari, S. H., Sorkina, E., Santini, F., Vigouroux, C., Brush, M. N., Meral, R., et al. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf103 · Cited by 9 · see citing works

Lipodistrofias primarias: presentación clínica y diagnóstico

Cortés, V., & Santos, J. L. (2019) · Revista médica de Chile · doi:10.4067/s0034-98872019001101449 · Cited by 9 · see citing works

Lovastatin for reduction of leptin in nondialysis patients with type 2 diabetic nephropathy.

Gholamin, S., Razavi, S., Taghavi-Garmestani, S.-M., Ghorbanihaghjo, A., Rashtchizadeh, N., Safa, J., Vatankhah, A. M., Azizi, T., & Argani, H. (2014) · Iranian Journal of Kidney Diseases · Cited by 9 · see citing works

Clinical Guidance for Lipodystrophy Syndromes: From Diagnosis and Work-Up to Treatment

Gilio, D., Foss‐Freitas, M. C., & Oral, E. A. (2025) · Current Diabetes Reports · doi:10.1007/s11892-025-01603-4 · Cited by 11 · see citing works

Metreleptin treatment of non-HIV lipodystrophy syndromes

Chevalier, B., Lemaître, M., Leguier, L., Mapihan, K. L., Douillard, C., Jannin, A., Espiard, S., & Vantyghem, M. (2021) · La Presse Médicale · doi:10.1016/j.lpm.2021.104070 · Cited by 8 · see citing works

Lipodystrophies in non-insulin-dependent children: Treatment options and results from recombinant human leptin therapy

Calcaterra, V., Magenes, V. C., Rossi, V., Fabiano, V., Mameli, C., & Zuccotti, G. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106629 · Cited by 6 · see citing works

Metreleptin in lipodystrophy: a profile of its use

Deeks, E. D. (2019) · Drugs & Therapy Perspectives · doi:10.1007/s40267-019-00622-y · Cited by 6 · see citing works

Lipodystrophie-Erkrankungen

Miehle, K., von Schnurbein, J., Faßhauer, M., Stümvoll, M., Borck, G., & Wabitsch, M. (2017) · Medizinische Genetik · doi:10.1007/s11825-017-0162-2 · Cited by 3 · see citing works

Kinetics of zinc status and zinc deficiency in Berardinelli-Seip syndrome

Santos, M. G. D. N., Baracho, M. D. F. P., Vale, S. H. D. L., Leite, L. D., Rocha, É. D. D. M., de Brito, N. J. N., França, M. C., Almeida, M. D. G., Chiquetti, S. C., Marchini, J. S., et al. (2012) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2011.11.002 · Cited by 5 · see citing works

Nephrotic range proteinuria associated with focal segmental glomerulosclerosis reversed with pioglitazone therapy in a patient with Dunnigan type lipodystrophy

Sharma, A., Bourey, R. E., Edwards, J. C., Brink, D. S., & Albert, S. G. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108620 · Cited by 5 · see citing works

Serum and urinary leptin and ghrelin in children with nephrotic syndrome.

Dinleyici, M., Yıldız, B., Çetin, N., Kural, N., & Alataş, Ö. (2013) · PubMed · Cited by 5 · see citing works

Risk factors for diabetic foot ulcers in metreleptin naïve patients with lipodystrophy

Saydam, O., Saydam, B. Ö., Adıyaman, S. C., Ince, M. S., Eren, M. E., Keskin, F., Bilen, H., Dağdeviren, M., Kaya, S., Akıncı, G., et al. (2021) · Clinical Diabetes and Endocrinology · doi:10.1186/s40842-021-00132-9 · Cited by 5 · see citing works

A very rare cause of acute pancreatitis: Berardinelli-Seip congenital lipodystrophy

İşlek, A., Sayar, E., Yılmaz, A., Duman, Ö., & Artan, R. (2014) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2014.3667 · Cited by 4 · see citing works

Lipodystrophy Syndromes

Gao, C., & Mantzoros, C. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00038-1 · Cited by 4 · see citing works

Membranous glomerulonephritis with an LMNA mutation

Fujita, K., & Hatta, K. (2018) · CEN Case Reports · doi:10.1007/s13730-018-0303-8 · Cited by 3 · see citing works

Effect of exogenous leptin on serum levels of lipids, glucose, renal and hepatic variables in both genders of obese and streptozotocin-induced diabetic rats.

Hayatdavoudi, P., Ghasemi, M., Zendehbad, B., Soukhtanloo, M., Golshan, A., & Hadjzadeh, M. (2015) · PubMed Central · Cited by 3 · see citing works

Advances of pharmacological therapies in lipodystrophy syndromes: current evidence and future directions

Besci, Ö., Güler, M. Ç., Foss‐Freitas, M. C., & Oral, E. A. (2025) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2025.2574318 · Cited by 2 · see citing works

Congenital generalized lipodystrophy in children: Berardinelli–Seip syndrome – two rare cases with renal manifestations

Rao, G. R., Satya, S., Prathima, K. M., Lavanya, D. S., Sandeep, K., & Amareswar, A. (2016) · Indian Journal of Paediatric Dermatology · doi:10.4103/2319-7250.193008 · Cited by 2 · see citing works

Podocytopathies associated with familial partial lipodystrophy due to LMNA variants: report of two cases

Morguetti, M. J., Neves, P. D. M. D. M., Korkes, I., Padilha, W. S. C., Jorge, L., Watanabe, A., Watanabe, E. H., Malheiros, D. M. A. C., Noronha, I. D. L., Dib, S. A., et al. (2024) · Archives of Endocrinology and Metabolism · doi:10.20945/2359-4292-2023-0204 · Cited by 2 · see citing works

Síndrome de Berardinelli-Seip en diálisis peritoneal

Bande-Fernández, J. J., García-Castro, R., Sánchez-Álvarez, J. E., Rodríguez-Suárez, C., Coronel, D., Hidalgo, C., Istanbuli, B., Bueno, C. M., & del Rio-García, L. (2015) · Nefrología · doi:10.1016/j.nefro.2015.08.002 · Cited by 2 · see citing works

The emerging clinical significance of leptin in humans with absolute or relative leptin deficiency

Moschos, S. J., & Mantzoros, C. S. (2005) · Current Opinion in Internal Medicine · doi:10.1097/01.med.0000177421.80858.74 · Cited by 2 · see citing works

Lipodystrophiesyndrome – klinische Präsentation und Management

Beghini, M., & Scherer, T. (2024) · Journal für Endokrinologie Diabetologie und Stoffwechsel · doi:10.1007/s41969-024-00255-1 · Cited by 1 · see citing works

A new type of familial partial lipodystrophy: distinctive fat distribution and proteinuria

Yürekli, B. Ş., Kutbay, N. Ö., Altay, C., Ünlü, Ş. M., Şen, S., Önay, H., Atık, T., & Akıncı, B. (2018) · Endocrine Research · doi:10.1080/07435800.2018.1470188 · Cited by 1 · see citing works

Clinical Applications of Leptin

Oral, E. A., & DePaoli, A. M. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_17

Severe generalized lipodystrophy as a rare presentation of fibrocalculous pancreatic diabetes - is there a common genetic link?

Shamas, M. N., Ganie, M. A., Ahmed, S., Laway, B. A., Pala, N. A., & Act, A. (2009) · Indian Journal of Endocrinology and Metabolism

Miscellaneous hormones

Dalan, R., & Leow, M. K. (2014) · Side effects of drugs annual · doi:10.1016/b978-0-444-62635-6.00043-7

METRELEPTINA: TRATAMIENTO PARA LAS COMPLICACIONES METABÓLICAS DE LA LIPODISTROFIA GENERALIZADA.

Lima-Martínez, M. M. (2016) · Actualidad Contable FACES

Akromegalie und generalisierte Lipodystrophie

Bock, F. D., Kiwit, U., Hilbert, P., & Horneff, G. (2007) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-007-1494-9

Berardinelli-Seip syndrome in peritoneal dialysis

Bande-Fernández, J. J., García-Castro, R., Sánchez-Álvarez, J. E., Rodríguez-Suárez, C., Coronel, D., Hidalgo, C., Istanbuli, B., Bueno, C. M., & del Rio-García, L. (2015) · Nefrología (English Edition) · doi:10.1016/j.nefroe.2015.11.005

Effects of Metreleptin on Proteinuria in Patients With Lipodystrophy

Lee, H. L., Waldman, M. A., Auh, S., Balow, J. E., Cochran, E. K., Görden, P., & Brown, R. J. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2019-00200 · Cited by 19 · see citing works

Renal complications of lipodystrophy: A closer look at the natural history of kidney disease

Akıncı, B., Ünlü, Ş. M., Çelik, A., Şimşir, İ. Y., Şen, S., Nur, B. G., Keskin, F. E., Saydam, B. Ö., Kutbay, N. Ö., Yürekli, B. Ş., et al. (2018) · Clinical Endocrinology · doi:10.1111/cen.13732 · Cited by 36 · see citing works

SUN-LB032 Severe Insulin Resistance and Nephrotic Range Proteinuria Reversed by Pioglitazone in a Patient With Dunnigan Type Lipodystrophy

Sharma, A., Nadella, S., & Albert, S. G. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-sun-lb032

Renal Disease in Partial Lipodystrophy

Eisinger, A. J., Shortland, J. R., & Moorhead, P. J. (1972) · QJM · doi:10.1093/oxfordjournals.qjmed.a067312 · Cited by 70 · see citing works

The renal manifestations of type 4 familial partial lipodystrophy: a case report and review of literature

Chen, R., Zhang, L., Ye, W., Wen, Y.-B., Si, N., Li, H., Li, M., Li, X., & Zheng, K. (2018) · BMC Nephrology · doi:10.1186/s12882-018-0913-6 · Cited by 18 · see citing works