Cited by 284Cardiovascular Health and Disease PreventionMenopause: Health Impacts and TreatmentsNitric Oxide and Endothelin Effects

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Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy

Kalantaridou, Sophia N., Naka, Katerina K., Papanikolaou, Evangelos, Kazakos, Nicolaos, Kravariti, Maria, Calis, Karim A., Paraskevaidis, Evangelos A., Sideris, Demetrios A., Tsatsoulis, Agathocles, Chrousos, George P., Michalis, Lampros K.·2004·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2004-0015

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Abstract

Normal menopause is associated with vascular endothelial dysfunction, an early stage of atherosclerosis. The effect of premature ovarian failure (or premature menopause) on endothelial function in young women is unknown. Endothelial function was assessed in 18 women with premature ovarian failure before and after 6 months of hormone therapy and was compared with the endothelial function of 20 age- and body mass index-matched premenopausal women. Brachial artery diameter was measured both during hyperemia (an index of endothelium-dependent vasodilation) and in response to glyceryl trinitrate (an index of endothelium-independent vaso-dilation). Flow-mediated dilation was significantly lower in women with premature ovarian failure at baseline (increase in brachial artery diameter during hyperemia by 3.06 +/- 4.33%) than in control women (increase by 8.84 +/- 2.15%; P < 0.0005). Glyceryl trinitrate-induced vasodilation did not differ between the groups. After hormone therapy for 6 months, flow-mediated dilation was improved in women with premature ovarian failure, increasing by more than 2-fold (7.41 +/- 3.86%; P < 0.005 compared with pretreatment) and reaching normal values (P not significant compared with control women). Glyceryl trinitrate-induced vasodilation did not change after treatment in women with premature ovarian failure. Young women with premature ovarian failure have significant vascular endothelial dysfunction. Early onset of endothelial dysfunction associated with sex steroid deficiency may contribute to the increased risk of cardiovascular disease and mortality in young women with premature ovarian failure. Hormone therapy restores endothelial function within 6 months of treatment.

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ESHRE Guideline: management of women with premature ovarian insufficiency
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See all 284

Authors: Kalantaridou, S. N., Naka, K. K., Papanikolaou, E., Kazakos, N., Kravariti, M., Calis, K. A., Paraskevaidis, E. A., Sideris, D. A., Tsatsoulis, A., Chrousos, G. P., & Michalis, L. K.
Affiliations: University of Ioannina (GR)
University Hospital of Ioannina (GR)
National Institutes of Health (US)
Corresponding author: Kalantaridou, Sophia N.
ORCID: Kalantaridou, Sophia N.
Paraskevaidis, Evangelos A.
Chrousos, George P.
Michalis, Lampros K.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2004-08
Volume: 89
Issue: 8
Pages: 3907-3913
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2004-0015
OpenAlex: W2104874274
Cited by: 284
References: 45
Citations by year: 2026: 9 · 2025: 15 · 2024: 19 · 2023: 19 · 2022: 16 · 2021: 20 · 2020: 20 · 2019: 18 · 2018: 10 · 2017: 17 · 2016: 19 · 2015: 7 · 2014: 11 · 2013: 3 · 2012: 14
FWCI: 5.01
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: premature ovarian failure, endothelial dysfunction, hormone therapy, estrogen replacement therapy, flow-mediated dilation, endothelium-dependent vasodilation, nitroglycerin, premature menopause, sex hormone deficiency, cardiovascular risk, young women
MeSH terms: Adult, Brachial Artery, Constriction, Endothelium, Vascular, Female, Nitroglycerin, Hand, Humans, Hyperemia, Regional Blood Flow, Ultrasonography, Vasodilation, Vasodilator Agents, Cohort Studies, Estrogen Replacement Therapy, Primary Ovarian Insufficiency

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Impaired Endothelial Function in Young Women with Premature Ovarian Failure: Normalization with Hormone Therapy

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