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The Differential Effects of Metformin on Markers of Endothelial Activation and Inflammation in Subjects with Impaired Glucose Tolerance: A Placebo-Controlled, Randomized Clinical Trial
Abstract
The effect of metformin (1000 mg twice a day) on markers of endothelial activation, inflammation, and coagulation was investigated in subjects with impaired glucose tolerance (IGT) in a 16-wk, randomized, placebo-controlled, double-blind study. Soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, C-reactive protein, TNFalpha, von Willebrand factor, and tissue plasminogen activator were measured at baseline and at the end of the trial. Subjects with IGT (n = 55, 14 males and 41 females), aged 48.4 +/- 9.6 yr with a body mass index of 31.4 +/- 5.6 kg/m(2), were studied. All participants followed a 1-month stabilization period in their diet and physical activity. Afterward, 29 subjects were assigned to the treatment group and 26 to the control group. A significant reduction in weight, fasting plasma glucose, soluble intercellular adhesion molecule (306 +/- 75 vs. 268 +/- 61 ng/ml, P = 0.029), soluble vascular cell adhesion molecule (595 +/- 114 vs. 508 +/- 126 ng/ml, P = 0.006), and von Willebrand factor (124 +/- 34 vs. 94 +/- 34%, P = 0.001) was seen in the treatment group, whereas tissue plasminogen activator, TNFalpha, and C-reactive protein levels did not change. No change was seen in the control group. Thus, metformin improves the plasma levels of some markers of endothelial activation and coagulation in subjects with IGT, whereas it has no effect on markers of inflammation.
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“Metformin has been proven as an anti-inflammatory, especially for the inflammation in diabetes and following postsurgical endotoxin [245,246,247].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [246]
Citations
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Items 101–151 of 151
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Instituto Nacional de Ciencias Neurológicas. Lima, P., Hurtado, I. R., Medina, M. D. P., Universidad Nacional Mayor de San Marcos. Lima, P., Escobedo, R. C., & Universidad de San Martín de Porres. Lima, P. (2019) · Horizonte Médico (Lima) · doi:10.24265/horizmed.2019.v19n3.08 · Cited by 4
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METFORMINA, FUNCION ARTERIAL Y GROSOR INTIMA-MEDIA EN SUJETOS CON SINDROME METABOLICO
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“Además existen numerosos estudios que evidencia una acción antiinflamatoria de la Metformina al ser capaz de disminuir diferentes mediadores como son: moléculas de adhesión, citocinas (TNF, IL-6, IL-1), factores de migración de macrófagos, proteína C reactiva, entre otros (9).”
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Yadav, S. K., Kambis, T. N., & Mishra, P. K. (2019) · Springer eBooks · doi:10.1007/978-981-13-8273-4_19
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“Furthermore, no certain normal range has been reported for that, however, CRP serum level of above 6 mg/L is an indicator of inflammation (23).”
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High Dose of Metformin Decreases Susceptibility to Occlusive Arterial Thrombosis in Diabetic MicePreprint
Mota, R. I., Annarapu, G. K., Sriniv, A. J., Liu, Z., Yazdani, H. O., Simmons, R. L., Shiva, S., Neal, M. D., & Nolfi-Donegan, D. (2023) · Research Square · doi:10.21203/rs.3.rs-3143156/v1
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Zhu, Y. (2014) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/1649
“Metformin, an effective anti-diabetic drug and AMPK activator, confers antiinflammatory features in impaired glucose tolerance (IGT) patients (104), IL-1β treated human vascular wall cells (105), LPS or oxidized LDL treated human monocytes (106), and endotoxin-induced uveitis rat model (107).”
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Metadata
- Authors
- Caballero, A. E., Delgado, A., Aguilar-Salinas, C. A., Herrera, A. N., Castillo, J. L., Cabrera, T., Gomez-Perez, F. J., & Rull, J. A.
- Affiliations
- Joslin Diabetes Center (US)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Corresponding author
- Aguilar-Salinas, Carlos A.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-08
- Volume
- 89
- Issue
- 8
- Pages
- 3943-3948
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2028079896
- Cited by
- 151
- References
- 42
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 10
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- metformin, impaired glucose tolerance, endothelial activation, inflammation, coagulation, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, von Willebrand factor, tissue plasminogen activator, C-reactive protein, TNF-α, weight loss, prediabetes
- MeSH terms
- Adult, Blood Glucose, Double-Blind Method, Endothelium, Vascular, Fasting, Female, Homeostasis, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Models, Biological, Solubility, Vasculitis, von Willebrand Factor, Biomarkers, Weight Loss, Cell Adhesion Molecules, Glucose Intolerance, Vascular Cell Adhesion Molecule-1
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