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Cited by 151Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

The DOI matches its Crossref record; 41 of the 42 references it cites were found in a registry or an index.

The Differential Effects of Metformin on Markers of Endothelial Activation and Inflammation in Subjects with Impaired Glucose Tolerance: A Placebo-Controlled, Randomized Clinical Trial

Caballero, A. Enrique, Delgado, Adriano, Aguilar-Salinas, Carlos A., Herrera, Alberto Naranjo, Castillo, Jose Luis, Cabrera, Tatiana, Gomez-Perez, Francisco J., Rull, Juan A.·2004·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2004-0019
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Abstract

The effect of metformin (1000 mg twice a day) on markers of endothelial activation, inflammation, and coagulation was investigated in subjects with impaired glucose tolerance (IGT) in a 16-wk, randomized, placebo-controlled, double-blind study. Soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, C-reactive protein, TNFalpha, von Willebrand factor, and tissue plasminogen activator were measured at baseline and at the end of the trial. Subjects with IGT (n = 55, 14 males and 41 females), aged 48.4 +/- 9.6 yr with a body mass index of 31.4 +/- 5.6 kg/m(2), were studied. All participants followed a 1-month stabilization period in their diet and physical activity. Afterward, 29 subjects were assigned to the treatment group and 26 to the control group. A significant reduction in weight, fasting plasma glucose, soluble intercellular adhesion molecule (306 +/- 75 vs. 268 +/- 61 ng/ml, P = 0.029), soluble vascular cell adhesion molecule (595 +/- 114 vs. 508 +/- 126 ng/ml, P = 0.006), and von Willebrand factor (124 +/- 34 vs. 94 +/- 34%, P = 0.001) was seen in the treatment group, whereas tissue plasminogen activator, TNFalpha, and C-reactive protein levels did not change. No change was seen in the control group. Thus, metformin improves the plasma levels of some markers of endothelial activation and coagulation in subjects with IGT, whereas it has no effect on markers of inflammation.

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Metadata

Authors
Caballero, A. E., Delgado, A., Aguilar-Salinas, C. A., Herrera, A. N., Castillo, J. L., Cabrera, T., Gomez-Perez, F. J., & Rull, J. A.
Affiliations
  • Joslin Diabetes Center (US)
  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
Corresponding author
Aguilar-Salinas, Carlos A.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2004-08
Volume
89
Issue
8
Pages
3943-3948
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2004-0019
OpenAlex
W2028079896
Cited by
151
References
42
Citations by year
2026: 2 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 9 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 10
FWCI
6.82
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
metformin, impaired glucose tolerance, endothelial activation, inflammation, coagulation, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, von Willebrand factor, tissue plasminogen activator, C-reactive protein, TNF-α, weight loss, prediabetes
MeSH terms
Adult, Blood Glucose, Double-Blind Method, Endothelium, Vascular, Fasting, Female, Homeostasis, Humans, Hypoglycemic Agents, Male, Metformin, Middle Aged, Models, Biological, Solubility, Vasculitis, von Willebrand Factor, Biomarkers, Weight Loss, Cell Adhesion Molecules, Glucose Intolerance, Vascular Cell Adhesion Molecule-1

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