The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Production in Vitro
Abstract
Adipose tissue IL-6 expression is increased in obesity and is a strong predictor of abnormalities in adipocyte and systemic metabolism. We used adipose tissue organ culture to test the direct effects of IL-6 on leptin expression, lipolysis, and lipoprotein lipase activity. To assess possible interactions with the hormonal milieu, IL-6 effects were tested in the presence or absence of insulin and/or glucocorticoid [dexamethasone (dex)]. Because omental (Om) and abdominal sc depots differ in IL-6 expression, their responses to exogenous IL-6 were compared. Although IL-6 had no significant effects under basal conditions, culture with the combination of IL-6 and dex, compared with dex alone, for 2 d increased leptin in both depots [+95 +/- 30% (sc) and +67 +/- 19% (Om), P < 0.01]; IL-6 did not affect leptin production when added in the presence of insulin. Culture with IL-6 in the absence of hormones moderately increased lipolysis during culture in both sc and Om [+79 +/- 23% (sc) and +26 +/- 9% (Om), each P < 0.01]. IL-6 markedly reduced the high levels of lipoprotein lipase activity in tissue cultured with insulin plus dex. We conclude that high local concentrations of IL-6 can modulate leptin production and lipid metabolism in human adipose tissue.
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Rotter, V., Nagaev, I., & Smith, U. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301977200 · Cited by 1,062
Sarraf, P., Frederich, R. C., Turner, E. M., Ma, G., Jaskowiak, N. T., Rivet, D. J., Flier, J. S., Lowell, B. B., Fraker, D. L., & Alexander, H. R. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.1.171 · Cited by 791
Interleukin-6 stimulates lipolysis and fat oxidation in humans
van Hall, G., Steensberg, A., Sacchetti, M., Fischer, C., Keller, C., Schjerling, P., Hiscock, N., Møller, K., Saltin, B., Febbraio, M. A., et al. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021687 · Cited by 767
Cited by
Pro-inflammatory cytokines: The link between obesity and osteoarthritis
Wang, T., & He, C. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.10.002 · Cited by 1,034
Metabolic Syndrome and Insulin Resistance: Underlying Causes and Modification by Exercise Training
Roberts, C. K., Hevener, A. L., & Barnard, R. J. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c110062 · Cited by 831
Role of innate and adaptive immunity in obesity-associated metabolic disease
McLaughlin, T., Ackerman, S. E., Shen, L., & Engleman, E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88876 · Cited by 444
The major inflammatory mediator interleukin-6 and obesity
Eder, K., Baffy, N., Falus, A., & Fulop, A. K. (2009) · Inflammation Research · doi:10.1007/s00011-009-0060-4 · Cited by 433
Cheng, K.-H., Chu, C.-S., Lee, K.-T., Lin, T.-H., Hsieh, C.-C., Chiu, C.-C., Voon, W.-C., Sheu, S.-H., & Lai, W.-T. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803726 · Cited by 362
Metadata
- Authors
- Trujillo, M. E., Sullivan, S., Harten, I., Schneider, S. H., Greenberg, A. S., & Fried, S. K.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-11
- Volume
- 89
- Issue
- 11
- Pages
- 5577-5582
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2133032991
- Cited by
- 248
- References
- 5
- FWCI
- 5.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Trujillo, M. E., Sullivan, S., Harten, I., Schneider, S. H., Greenberg, A. S., & Fried, S. K. (2004). Interleukin-6 Regulates Human Adipose Tissue Lipid Metabolism and Leptin Production in Vitro. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2004-0603
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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