The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Role of innate and adaptive immunity in obesity-associated metabolic disease
Open accessAbstract
Potential role of gut inflammation in disease developmentIn addition to AT, recent evidence suggests that the intestine is also a key site that becomes altered in obesity-related IR.These Chronic inflammation in adipose tissue, possibly related to adipose cell hypertrophy, hypoxia, and/or intestinal leakage of bacteria and their metabolic products, likely plays a critical role in the development of obesity-associated insulin resistance (IR).Cells of both the innate and adaptive immune system residing in adipose tissues, as well as in the intestine, participate in this process.Thus, M1 macrophages, IFN-γ-secreting Th1 cells, CD8 + T cells, and B cells promote IR, in part through secretion of proinflammatory cytokines.Conversely, eosinophils, Th2 T cells, type 2 innate lymphoid cells, and possibly Foxp3 + Tregs protect against IR through local control of inflammation.
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Cites
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Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
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Cited by
Inflammatory mechanisms linking obesity and metabolic disease
Saltiel, A. R., & Olefsky, J. M. (2017) · Journal of Clinical Investigation · doi:10.1172/jci92035 · Cited by 2,212
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066
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Chronic Adipose Tissue Inflammation Linking Obesity to Insulin Resistance and Type 2 Diabetes
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Metabolic Inflammation and Insulin Resistance in Obesity
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Metadata
- Authors
- McLaughlin, T., Ackerman, S. E., Shen, L., & Engleman, E.
- Venue
- Journal of Clinical Investigation
- Published
- 2017-01-03
- Volume
- 127
- Issue
- 1
- Pages
- 5-13
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W2562831699
- Cited by
- 444
- References
- 120
- FWCI
- 25.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
