Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression

Identification of Specific Sites of Hormonal Regulation in Spermatogenesis in Rats, Monkeys, and Man

McLachlan, R. I. (2002) · Recent Progress in Hormone Research · doi:10.1210/rp.57.1.149 · Cited by 419 · see citing works

On the Androgen Microenvironment of Maturing Spermatozoa*

Turner, T. T., Jones, C. E., Howards, S. S., EWING, L. L., ZEGEYE, B., & Gunsalus, G. L. (1984) · Endocrinology · doi:10.1210/endo-115-5-1925 · Cited by 324 · see citing works

Maintenance of Advanced Spermatogenic Cells in the Adult Rat Testis: Quantitative Relationship to Testosterone Concentration within the Testis*

Zirkin, B. R., Santulli, R. J., Awoniyi, C. A., & EWING, L. L. (1989) · Endocrinology · doi:10.1210/endo-124-6-3043 · Cited by 309 · see citing works

Contraceptive efficacy of testosterone‐induced azoospermia in normal men

ZHANG, G. ‐., Li, G., Wu, F. C. W., Baker, H. W. G., Wang, X., Soufir, J. C., Huhtaniemi, I. T., Paulsen, C. A., Gottlieb, C., Handelsman, D. J., et al. (1991) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(91)90685-x · Cited by 245 · see citing works

Stimulation of Spermatogenesis by Gonadotropins in Men with Hypogonadotropic Hypogonadism

Finkel, D. M., Phillips, J. L., & Snyder, P. J. (1985) · New England Journal of Medicine · doi:10.1056/nejm198509123131102 · Cited by 240 · see citing works

Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach

Bebb, R. A., Anawalt, B. D., Christensen, R. B., Paulsen, C. A., Bremner, W. J., & Matsumoto, A. M. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.2.8636300 · Cited by 224 · see citing works

Effects of Testosterone Plus Medroxyprogesterone Acetate on Semen Quality, Reproductive Hormones, and Germ Cell Populations in Normal Young Men

McLachlan, R. I., O’Donnell, L., Stanton, P. G., Balourdos, G., Frydenberg, M., de Kretser, D. M., & Robertson, D. M. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.546 · Cited by 191 · see citing works

Effects of Chronic Testosterone Administration in Normal Men: Safety and Efficacy of High Dosage Testosterone and Parallel Dose-Dependent Suppression of Luteinizing Hormone, Follicle-Stimulating Hormone, and Sperm Production*

Matsumoto, A. M. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-1-282 · Cited by 189 · see citing works

Chronic Human Chorionic Gonadotropin Admininstration in Normal Men: Evidence that Follicle-Stimulating Hormone Is Necessary for the Maintenance of Quatitatively Normal Spermatogenesis in Man *

Matsumoto, A. M., Karpas, A. E., & Bremner, W. J. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-6-1184 · Cited by 181 · see citing works

Hormonal Regulation of Spermatogenesis in Primates and Man: Insights for Development of the Male Hormonal Contraceptive

McLachlan, R. I., O’Donnell, L., Meachem, S. J., Stanton, P. G., de Kretser, D. M., PRATIS, K., & Robertson, D. M. (2002) · Journal of Andrology · doi:10.1002/j.1939-4640.2002.tb02607.x · Cited by 179 · see citing works

Hormone substitution in male hypogonadism

Zitzmann, M., & Nieschlag, E. (2000) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(99)00227-0 · Cited by 166 · see citing works

Intratesticular Testosterone Concentrations Comparable With Serum Levels Are Not Sufficient to Maintain Normal Sperm Production in Men Receiving a Hormonal Contraceptive Regimen

Coviello, A. D., Bremner, W. J., Matsumoto, A. M., Herbst, K. L., Amory, J. K., Anawalt, B. D., Yan, X., Brown, T. R., Wright, W. W., Zirkin, B. R., et al. (2004) · Journal of Andrology · doi:10.1002/j.1939-4640.2004.tb03164.x · Cited by 150 · see citing works

The low gonadotropin-independent constitutive production of testicular testosterone is sufficient to maintain spermatogenesis

Zhang, F., Pakarainen, T., POUTANEN, M. H., Toppari, J., & Huhtaniemi, I. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2232815100 · Cited by 143 · see citing works

Efficacy and safety of recombinant human follicle stimulating hormone (Gonal-F) with urinary human chorionic gonadotrophin for induction of spermatogenesis and fertility in gonadotrophin-deficient men

Liu, P. Y., Turner, L., Rushford, D., McDonald, J., Baker, H. W. G., Conway, A. J., & Handelsman, D. J. (1999) · Human Reproduction · doi:10.1093/humrep/14.6.1540 · Cited by 136 · see citing works

Two-Year Comparison of Testicular Responses to Pulsatile Gonadotropin-Releasing Hormone and Exogenous Gonadotropins From the Inception of Therapy in Men With Isolated Hypogonadotropic Hypogonadism

Liu, L. L., Banks, S. M., BARNES, K. M., & Sherins, R. J. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-6-1140 · Cited by 129 · see citing works

Testosterone Administration Inhibits Gonadotropin Secretion by an Effect Directly on the Human Pituitary*

SHECKTER, C. B., Matsumoto, A. M., & Bremner, W. J. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-2-397 · Cited by 119 · see citing works

A low sperm concentration does not preclude fertility in men with isolated hypogonadotropic hypogonadism after gonadotropin therapy

Burris, A. S., Clark, R. V., Vantman, D., & Sherins, R. J. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60084-5 · Cited by 116 · see citing works

Assessment of the Androgen Environment Within the Human Testis: Minimally Invasive Method to Obtain Intratesticular Fluid

Jarow, J. P., CHEN, H., Rosner, W., Trentacoste, S., & Zirkin, B. R. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb02224.x · Cited by 115 · see citing works

A Lower Dosage Levonorgestrel and Testosterone Combination Effectively Suppresses Spermatogenesis and Circulating Gonadotropin Levels with Fewer Metabolic Effects Than Higher Dosage Combinations

Anawalt, B. D., Bebb, R. A., Bremner, W. J., & Matsumoto, A. M. (1999) · Journal of Andrology · doi:10.1002/j.1939-4640.1999.tb02535.x · Cited by 113 · see citing works

Comparison of a gonadotropin releasing-hormone antagonist plus testosterone (T) versus T alone as potential male contraceptive regimens

Bagatell, C. J., Matsumoto, A. M., Christensen, R. B., Rivier, J., & Bremner, W. J. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.77.2.427 · Cited by 108 · see citing works

Testosterone Concentrations in Testes of Normal Men: Effects of Testosterone Propionate Administration

Morse, H. C., Horike, N. R., Rowley, M. J., & Heller, C. G. (1973) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-37-6-882 · Cited by 105 · see citing works

Testicular Steroidogenesis in the Aging Brown Norway Rat

Zirkin, B. R., Santulli, R. J., Strandberg, J. D., Wright, W. W., & EWING, L. L. (1993) · Journal of Andrology · doi:10.1002/j.1939-4640.1993.tb01663.x · Cited by 102 · see citing works

Restoration of Advanced Spermatogenic Cells in the Experimentally Regressed Rat Testis: Quantitative Relationship to Testosterone Concentration within the Testis*

Awoniyi, C. A., Santulli, R. J., Sprando, R. L., EWING, L. L., & Zirkin, B. R. (1989) · Endocrinology · doi:10.1210/endo-124-3-1217 · Cited by 100 · see citing works

Comparison of Testosterone, Dihydrotestosterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in Serum after Injection of Testosterone Enanthate or Testosterone Cypionate

Schulte-Beerbühl, M., & Nieschlag, E. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44543-7 · Cited by 96 · see citing works

Recombinant human follicle-stimulating hormone and human chorionic gonadotropin for induction of spermatogenesis in a hypogonadotropic male

Kliesch, S., Behre, H. M., & Nieschlag, E. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57619-5 · Cited by 90 · see citing works

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. III. Higher 5 alpha-reductase activity in oligozoospermic men administered supraphysiological doses of testosterone.

Anderson, R. A., Wallace, E. M., & Wu, F. C. W. (1996) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.81.3.8772548 · Cited by 90 · see citing works

Quantitative Restoration of Advanced Spermatogenic Cells in Adult Male Rats Made Azoospermic by Active Immunization against Luteinizing Hormone or Gonadotropin-Releasing Hormone*

Awoniyi, C. A., Santulli, R. J., Chandrashekar, V., SCHANBACHER, B. D., & Zirkin, B. R. (1989) · Endocrinology · doi:10.1210/endo-125-3-1303 · Cited by 90 · see citing works

Human Chorionic Gonadotropin and Testicular Function: Stimulation of Testosterone, Testosterone Precursors, and Sperm Production Despite High Estradiol Levels*

Matsumoto, A. M., Paulsen, C. A., HOPPER, B. R., Rebar, R. W., & Bremner, W. J. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-4-720 · Cited by 79 · see citing works

Restoration of Spermatogenesis by Exogenously Administered Testosterone in Rats Made Azoospermic by Hypophysectomy or Withdrawal of Luteinizing Hormone Alone*

Awoniyi, C. A., Sprando, R. L., Santulli, R. J., Chandrashekar, V., EWING, L. L., & Zirkin, B. R. (1990) · Endocrinology · doi:10.1210/endo-127-1-177 · Cited by 76 · see citing works

A Comparison of the Suppressive Effects of Testosterone and a Potent New Gonadotropin-Releasing Hormone Antagonist on Gonadotropin and Inhibin Levels in Normal Men*

Bagatell, C. J., McLachlan, R. I., de Kretser, D. M., Burger, H., Vale, W., Rivier, J., & Bremner, W. J. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-69-1-43 · Cited by 66 · see citing works

Progestin‐Androgen Combination Regimens for Male Contraception

Meriggiola, M. C., & Bremner, W. J. (1997) · Journal of Andrology · doi:10.1002/j.1939-4640.1997.tb01913.x · Cited by 62 · see citing works

MAINTENANCE OF SPERMATOGENESIS INDUCED BY HMG TREATMENT BY MEANS OF CONTINUOUS HCG TREATMENT IN HYPOGONADOTROPHIC MEN

Johnsen, S. G. (1978) · European Journal of Endocrinology · doi:10.1530/acta.0.0890763 · Cited by 55 · see citing works

Stimulation of Sperm Production by Human Chorionic Gonadotropin after Prolonged Gonadotropin Suppression in Normal Men

Matsumoto, A. M., & Bremner, W. J. (1985) · Journal of Andrology · doi:10.1002/j.1939-4640.1985.tb00829.x · Cited by 50 · see citing works

Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. I: Plasma luteinizing hormone, follicle stimulating hormone, testosterone, estradiol, and inhibin concentrations.

Wallace, E. M., Gow, S., & Wu, F. C. W. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.1.8325955 · Cited by 50 · see citing works

Simultaneous Determination of Testosterone, 5α-Androstan-17µ-ol-3-one, 5α-Androstane-3α,17µ-diol and 5a-Androstane-3µ,17µ-diol in Plasma of Adult Male Rabbits by Radioimmunoassay11

SCHANBACHER, B. D., & EWING, L. L. (1975) · Endocrinology · doi:10.1210/endo-97-4-787 · Cited by 50 · see citing works

Endocrine control of human spermatogenesis

Matsumoto, A. M., & Bremner, W. J. (1989) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(89)90493-7 · Cited by 39 · see citing works

Can Spermatogenesis Be Maintained Quantitatively in Intact Adult Rats with Exogenously Administered Dihydrotestosterone?

CHEN, H., Chandrashekar, V., & Zirkin, B. R. (1994) · Journal of Andrology · doi:10.1002/j.1939-4640.1994.tb00417.x · Cited by 35 · see citing works

Daily Testosterone and Gonadotropin Levels Are Similar in Azoospermic and Nonazoospermic Normal Men Administered Weekly Testosterone: Implications for Male Contraceptive Development

Amory, J. K., Anawalt, B. D., Bremner, W. J., & Matsumoto, A. M. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb03445.x · Cited by 33 · see citing works

Dose effects of the gonadotropin-releasing hormone antagonist, Nal-Glu, combined with testosterone enanthate on gonadotropin levels in normal men

Bagatell, C. J., Rivier, J., & Bremner, W. J. (1995) · Fertility and Sterility · doi:10.1016/s0015-0282(16)57670-5 · Cited by 18 · see citing works

On the maintenance of male fertility in the absence of native testosterone secretion: site-directed hormonal therapy in the rat

Turner, T. T., Howards, S. S., & Gleavy, J. L. (1990) · Fertility and Sterility · doi:10.1016/s0015-0282(16)53652-8 · Cited by 16 · see citing works

Advances in Male Contraception

Page, S. T., Amory, J. K., & Bremner, W. J. (2008) · Endocrine Reviews · doi:10.1210/er.2007-0041 · Cited by 1,134 · see citing works

Male infertility

Eisenberg, M. L., Esteves, S. C., Lamb, D. J., Hotaling, J. M., Giwercman, A., Hwang, K., & Cheng, Y.-S. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00459-w · Cited by 536 · see citing works

Spermatogenesis in humans and its affecting factors

Neto, F. T. L., Bach, P. V., Najari, B. B., Li, P. S., & Goldstein, M. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.04.009 · Cited by 524 · see citing works

Obesity and Male Reproductive Potential

Hammoud, A. O., Gibson, M., Peterson, C. M., Hamilton, B. D., & Carrell, D. T. (2006) · Journal of Andrology · doi:10.2164/jandrol.106.000125 · Cited by 206 · see citing works

Physiology of Testicular Function

Weinbauer, G. F., Luetjens, C. M., Simoni, M., & Nieschlag, E. (2010) · Springer eBooks · doi:10.1007/978-3-540-78355-8_2 · Cited by 178 · see citing works

The Androgen Microenvironment of the Human Testis and Hormonal Control of Spermatogenesis

Jarow, J. P., & Zirkin, B. R. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1336.023 · Cited by 157 · see citing works

Approach to Male Infertility and Induction of Spermatogenesis

Anawalt, B. D. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2400 · Cited by 126 · see citing works

Negative Effect of Increased Body Weight on Sperm Conventional and Nonconventional Flow Cytometric Sperm Parameters

Vignera, S. L., Condorelli, R. A., Vicari, E. S. D., & Calogero, A. E. (2011) · Journal of Andrology · doi:10.2164/jandrol.110.012120 · Cited by 112 · see citing works

Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use

Coward, R. M., & McBride, J. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.173938 · Cited by 111 · see citing works

Concomitant Intramuscular Human Chorionic Gonadotropin Preserves Spermatogenesis in Men Undergoing Testosterone Replacement Therapy

Hsieh, T., Pastuszak, A. W., Hwang, K., & Lipshultz, L. I. (2012) · The Journal of Urology · doi:10.1016/j.juro.2012.09.043 · Cited by 109 · see citing works

The Use of HCG-Based Combination Therapy for Recovery of Spermatogenesis after Testosterone Use

Wenker, E. P., Dupree, J. M., Langille, G. M., Kovac, J., Ramasamy, R., Lamb, D., Mills, J. N., & Lipshultz, L. I. (2015) · The Journal of Sexual Medicine · doi:10.1111/jsm.12890 · Cited by 101 · see citing works

Androgen Misuse and Abuse.

Handelsman, D. (2021) · Endocrine reviews · doi:10.1210/endrev/bnab001 · Cited by 67 · see citing works

The Relative Roles of Follicle-Stimulating Hormone and Luteinizing Hormone in Maintaining Spermatogonial Maturation and Spermiation in Normal Men

Matthiesson, K. L., McLachlan, R. I., O’Donnell, L., Frydenberg, M., Robertson, D. M., Stanton, P. G., & Meachem, S. J. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1145 · Cited by 90 · see citing works

The treatment of hypogonadism in men of reproductive age

Kim, E. D., Crosnoe, L., Bar-Chama, N., Khera, M., & Lipshultz, L. I. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.10.052 · Cited by 89 · see citing works

On-label and off-label drugs used in the treatment of male infertility

Chehab, M., Madala, A., & Trussell, J. C. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.12.122 · Cited by 88 · see citing works

Current medical management of endocrine-related male infertility

Ring, J., Lwin, A., & Köhler, T. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.179252 · Cited by 87 · see citing works

Contemporary concepts in the evaluation and management of male infertility

Hwang, K., Walters, R. C., & Lipshultz, L. I. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2010.230 · Cited by 84 · see citing works

Testosterone Is a Contraceptive and Should Not Be Used in Men Who Desire Fertility

Patel, A. S., Leong, J. Y., Ramos, L., & Ramasamy, R. (2018) · The World Journal of Men s Health · doi:10.5534/wjmh.180036 · Cited by 86 · see citing works

The effect of human chorionic gonadotropin-based hormonal therapy on intratesticular testosterone levels and spermatogonial DNA synthesis in men with non-obstructive azoospermia

Shinjo, E., Shiraishi, K., & Matsuyama, H. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00141.x · Cited by 80 · see citing works

Testosterone and Male Infertility

Ohlander, S. J., Lindgren, M. C., & Lipshultz, L. I. (2016) · Urologic Clinics of North America · doi:10.1016/j.ucl.2016.01.006 · Cited by 77 · see citing works

Current and emerging medical therapeutic agents for idiopathic male infertility

Duca, Y., Calogero, A. E., Cannarella, R., Condorelli, R. A., & Vignera, S. L. (2018) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2018.1543405 · Cited by 77 · see citing works

Endocrinopathies and Male Infertility

Sengupta, P., Dutta, S., Karkada, I. R., & Chinni, S. V. (2021) · Life · doi:10.3390/life12010010 · Cited by 75 · see citing works

The practical management of testosterone deficiency in men

Aversa, A., & Morgentaler, A. (2015) · Nature Reviews Urology · doi:10.1038/nrurol.2015.238 · Cited by 74 · see citing works

Update on male reproductive endocrinology

Clavijo, R. I., & Hsiao, W. (2018) · Translational Andrology and Urology · doi:10.21037/tau.2018.03.25 · Cited by 70 · see citing works

Exogenous testosterone: a preventable cause of male infertility.

Crosnoe-Shipley, L., Grober, E. D., Ohl, D. A., & Kim, E. D. (2013) · PubMed Central · doi:10.3978/j.issn.2223-4683.2013.06.01 · Cited by 72 · see citing works

Effects of Testosterone and Levonorgestrel Combined with a 5α-Reductase Inhibitor or Gonadotropin-Releasing Hormone Antagonist on Spermatogenesis and Intratesticular Steroid Levels in Normal Men

Matthiesson, K. L., Stanton, P. G., O’Donnell, L., Meachem, S. J., Amory, J. K., Berger, R. E., Bremner, W. J., & McLachlan, R. I. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0639 · Cited by 67 · see citing works

Age and duration of testosterone therapy predict time to return of sperm count after human chorionic gonadotropin therapy

Kohn, T. P., Louis, M. R., Pickett, S. M., Lindgren, M. C., Kohn, J. R., Pastuszak, A. W., & Lipshultz, L. I. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.10.004 · Cited by 67 · see citing works

Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery

Tatem, A. J., Beilan, J., Kovac, J. R., & Lipshultz, L. I. (2020) · The World Journal of Men's Health · doi:10.5534/wjmh.190002 · Cited by 66 · see citing works

The Roles of MicroRNAs in Male Infertility

Barbu, M. G., Thompson, D. C., Suciu, N., Voinea, S. C., Crețoiu, D., & Predescu, D. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062910 · Cited by 65 · see citing works

Hormonal approaches to male contraception

Wang, C., & Swerdloff, R. S. (2010) · Current Opinion in Urology · doi:10.1097/mou.0b013e32833f1b4a · Cited by 64 · see citing works

Dose-Dependent Increase in Intratesticular Testosterone by Very Low-Dose Human Chorionic Gonadotropin in Normal Men with Experimental Gonadotropin Deficiency

Roth, M. Y., Page, S. T., Lin, K., Anawalt, B. D., Matsumoto, A. M., Snyder, C. N., Marck, B. T., Bremner, W. J., & Amory, J. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0360 · Cited by 64 · see citing works

Serum LH Correlates Highly With Intratesticular Steroid Levels in Normal Men

Roth, M. Y., Lin, K., Amory, J. K., Matsumoto, A. M., Anawalt, B. D., Snyder, C. N., Kalhorn, T. F., Bremner, W. J., & Page, S. T. (2010) · Journal of Andrology · doi:10.2164/jandrol.109.008391 · Cited by 58 · see citing works

Effect of rejuvenation hormones on spermatogenesis

Moss, J. L., Crosnoe-Shipley, L., & Kim, E. D. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.003 · Cited by 56 · see citing works

Late-onset hypogonadism: the advantages of treatment with human chorionic gonadotropin rather than testosterone

Vignera, S. L., Condorelli, R. A., Cimino, L., Russo, G. I., Morgia, G., & Calogero, A. E. (2015) · The Aging Male · doi:10.3109/13685538.2015.1092021 · Cited by 56 · see citing works

Infertility in the light of new scientific reports – focus on male factor

Szkodziak, P. R., Woźniak, S., Czuczwar, P., Woźniakowska, E., Milart, P., Mroczkowski, A., & Paszkowski, T. (2016) · Annals of Agricultural and Environmental Medicine · doi:10.5604/12321966.1203881 · Cited by 56 · see citing works

Steroid hormones for contraception in men

Grimes, D. A., Lopez, L. M., Gallo, M. F., Halpern, V., Nanda, K., & Schulz, K. F. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004316.pub4 · Cited by 55 · see citing works

Indications for the use of human chorionic gonadotropic hormone for the management of infertility in hypogonadal men

Lee, J. A., & Ramasamy, R. (2018) · Translational Andrology and Urology · doi:10.21037/tau.2018.04.11 · Cited by 55 · see citing works

Preserving fertility in the hypogonadal patient: an update

Lipshultz, L. I., Ramasamy, R., & Armstrong, J. M. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.142772 · Cited by 53 · see citing works

Intratesticular Androgens and Spermatogenesis During Severe Gonadotropin Suppression Induced by Male Hormonal Contraceptive Treatment

Page, S. T., Kalhorn, T. F., Bremner, W. J., Anawalt, B. D., Matsumoto, A. M., & Amory, J. K. (2007) · Journal of Andrology · doi:10.2164/jandrol.107.002790 · Cited by 51 · see citing works

Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial

Roth, M. Y., Lin, K., Bay, K., Amory, J. K., Anawalt, B. D., Matsumoto, A. M., Marck, B. T., Bremner, W. J., & Page, S. T. (2012) · Fertility and Sterility · doi:10.1016/j.fertnstert.2012.09.009 · Cited by 45 · see citing works

APHRODITE criteria: addressing male patients with hypogonadism and/or infertility owing to altered idiopathic testicular function

Esteves, S. C., Humaidan, P., Ubaldi, F. M., Alviggi, C., Antonio, L., Barratt, C. L. R., Behre, H. M., Jørgensen, N., Pacey, A. A., Simoni, M., et al. (2023) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2023.103647 · Cited by 45 · see citing works

An approach to constitutional delay of growth and puberty

Soliman, A. T., & Sanctis, V. D. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.100650 · Cited by 42 · see citing works

Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin

Amory, J. K., Coviello, A. D., Page, S. T., Anawalt, B. D., Matsumoto, A. M., & Bremner, W. J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.02.059 · Cited by 42 · see citing works

Testosterone Replacement Therapy in Hypogonadal Men

Wang, C., & Swerdloff, R. S. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.005 · Cited by 45 · see citing works

Medical and Surgical Management Male Infertility

Schiff, J. D., Ramírez, M. L., & Bar-Chama, N. C. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2007.03.003 · Cited by 40 · see citing works

Male hormonal contraception: concept proven, product in sight?

Matthiesson, K. L., & McLachlan, R. I. (2006) · Human Reproduction Update · doi:10.1093/humupd/dml010 · Cited by 40 · see citing works

Androgen abuse: Risks and adverse effects in men

Grant, B., Hyams, E., Davies, R., Minhas, S., & Jayasena, C. N. (2024) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.15187 · Cited by 37 · see citing works

Non-testosterone management of male hypogonadism: an examination of the existing literature

Krzastek, S. C., & Smith, R. P. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.11.16 · Cited by 34 · see citing works

Pubertal induction in hypogonadism: Current approaches including use of gonadotrophins

Zacharin, M. (2015) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2015.01.002 · Cited by 34 · see citing works

Understanding and managing the suppression of spermatogenesis caused by testosterone replacement therapy (TRT) and anabolic–androgenic steroids (AAS)

Desai, A., Yassin, M., Cayetano-Alcaráz, A. A., Tharakan, T., Jayasena, C. N., & Minhas, S. (2022) · Therapeutic Advances in Urology · doi:10.1177/17562872221105017 · Cited by 34 · see citing works

Hormonal therapy for non‐obstructive azoospermia: basic and clinical perspectives

Shiraishi, K. (2014) · Reproductive Medicine and Biology · doi:10.1007/s12522-014-0193-1 · Cited by 30 · see citing works

Exogenous testosterone replacement therapy versus raising endogenous testosterone levels: current and future prospects

Khodamoradi, K., Khosravizadeh, Z., Parmar, M., Kuchakulla, M., Ramasamy, R., & Arora, H. (2020) · F&S Reviews · doi:10.1016/j.xfnr.2020.11.001 · Cited by 29 · see citing works

Physiologic role and regulation of intratesticular sex steroids

Page, S. T. (2011) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e328345d50e · Cited by 29 · see citing works

Update on Male Hormonal Contraception: Is the Vasectomy in Jeopardy?

Manetti, G. J., & Honig, S. C. (2010) · International Journal of Impotence Research · doi:10.1038/ijir.2010.2 · Cited by 29 · see citing works

Treatment of hypogonadotropic male hypogonadism: Case-based scenarios

Crosnoe-Shipley, L. (2015) · World Journal of Nephrology · doi:10.5527/wjn.v4.i2.245 · Cited by 29 · see citing works

Anabolic androgenic steroid‐induced hypogonadism, a reversible condition in male individuals? A systematic review

Neto, J. D. O. V., Silva, C. A., da Silva, C. A. B., Pinto, D. V., Caminha, J. D. S. R., de Matos, R. S., Filho, J. C. C. N., Alves, F. R., Magalhães, S. C., & Daher, E. D. F. (2021) · Andrologia · doi:10.1111/and.14062 · Cited by 28 · see citing works

Systematic review of hormone replacement therapy in the infertile man

Meliegy, A. E., Motawi, A. T., & Salam, M. A. A. E. (2017) · Arab Journal of Urology · doi:10.1016/j.aju.2017.11.011 · Cited by 28 · see citing works

Management of Male Fertility in Hypogonadal Patients on Testosterone Replacement Therapy

Fink, J. E., Ide, H., & Horie, S. (2024) · Medicina · doi:10.3390/medicina60020275 · Cited by 28 · see citing works

Testosterone deficiency: myth, facts, and controversy.

Miner, M. M., Barkin, J., & Rosenberg, M. T. (2014) · PubMed · Cited by 27 · see citing works

Human chorionic gonadotropin treatment: a viable option for management of secondary hypogonadism and male infertility

Fink, J. E., Schoenfeld, B. J., Hackney, A. C., Maekawa, T., & Horie, S. (2020) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2021.1863783 · Cited by 27 · see citing works

Detection of anabolic androgenic steroid use by elite athletes and by members of the general public

Anawalt, B. D. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.027 · Cited by 26 · see citing works

Steroid hormones for contraception in men

Grimes, D. A., Lopez, L. M., Gallo, M. F., Halpern, V., Nanda, K., & Schulz, K. F. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004316.pub3 · Cited by 25 · see citing works

Leydig cell aging: Molecular mechanisms and treatments

Papadopoulos, V., & Zirkin, B. R. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2020.12.023 · Cited by 23 · see citing works

Testosterone: biosynthesis, transport, metabolism and (non-genomic) actions

Luetjens, C. M., & Weinbauer, G. F. (2012) · Cambridge University Press eBooks · doi:10.1017/cbo9781139003353.003 · Cited by 23 · see citing works

Testosterone replacement in the infertile man

Majzoub, A. A., & Sabanegh, E. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.08.03 · Cited by 22 · see citing works

Canadian Urological Association clinical practice guideline on testosterone deficiency in men: Evidence-based Q&A

Grober, E. D., Krakowsky, Y., Khera, M., Holmes, D. T., Jc, L., Grantmyre, J. E., Patel, P., Bebb, R. A., Fitzpatrick, R., Campbell, J. D., et al. (2021) · Canadian Urological Association Journal · doi:10.5489/cuaj.7252 · Cited by 25 · see citing works

Anabolic steroid misuse and male infertility: management and strategies to improve patient awareness

Whitaker, D. L., Geyer-Kim, G., & Kim, E. D. (2021) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2021.1921574 · Cited by 24 · see citing works

Vasectomy Reversal Outcomes in Men Previously on Testosterone Supplementation Therapy

Coward, R. M., Mata, D. A., Smith, R. P., Kovac, J. R., & Lipshultz, L. I. (2014) · Urology · doi:10.1016/j.urology.2014.06.081 · Cited by 20 · see citing works

Alternatives to testosterone replacement: testosterone restoration

McCullough, A. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.143736 · Cited by 18 · see citing works

Can serum 17-hydroxyprogesterone and insulin-like factor 3 be used as a marker for evaluation of intratesticular testosterone?

Patel, A., Patel, P., Bitran, J., & Ramasamy, R. (2019) · Translational Andrology and Urology · doi:10.21037/tau.2019.01.16 · Cited by 17 · see citing works

Testosterone replacement therapy and spermatogenesis in reproductive age men

Naelitz, B. D., Momtazi-Mar, L., Vallabhaneni, S., Cannarella, R., Vij, S. C., Parekh, N. V., Bole, R., & Lundy, S. D. (2025) · Nature Reviews Urology · doi:10.1038/s41585-025-01032-8 · Cited by 20 · see citing works

Testosterone undecanoate supplementation together with human chorionic gonadotropin does not impair spermatogenesis in males with isolated hypogonadotropic hypogonadism: a retrospective study

Liu, J., Chen, Y., Niu, Y., Xu, H., Wang, D., Jiang, H., Pokhrel, G., Wang, T., & Wang, S. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_107_18 · Cited by 16 · see citing works

Off label therapies for testosterone replacement

DiGiorgio, L., & Sadeghi‐Nejad, H. (2016) · Translational Andrology and Urology · doi:10.21037/tau.2016.08.15 · Cited by 13 · see citing works

Androgen Synthesis in the Gonadotropin-Suppressed Human Testes Can Be Markedly Suppressed by Ketoconazole

Roth, M. Y., Nya‐Ngatchou, J. J., Lin, K., Page, S. T., Anawalt, B. D., Matsumoto, A. M., Marck, B. T., Bremner, W. J., & Amory, J. K. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3527 · Cited by 14 · see citing works

Expression and characterization of androgen receptor coregulators, SRC-2 and HBO1, during human testis ontogenesis and in androgen signaling deficient patients

Vija, L., Méduri, G., Compérat, É., Vasiliu, V., Izard, V., Ferlicot, S., Boukari, K., Camparo, P., Viengchareun, S., Constancis, E., et al. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.05.004 · Cited by 14 · see citing works

The Physiology of the Testis

Ilacqua, A., Francomano, D., & Aversa, A. (2018) · Endocrinology · doi:10.1007/978-3-319-44675-2_17 · Cited by 14 · see citing works

Fertility Considerations in Hypogonadal Men

Papanikolaou, N., Luo, R., & Jayasena, C. N. (2022) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2021.11.009 · Cited by 11 · see citing works

Investigating the basis of sexual dysfunction during late-onset hypogonadism

Tharakan, T., Miah, S., Jayasena, C. N., & Minhas, S. (2019) · F1000Research · doi:10.12688/f1000research.16561.1 · Cited by 9 · see citing works

Clomiphene citrate and optional human chorionic gonadotropin for treating male hypogonadism arising from long-term anabolic-androgenic steroid use—A pilot study

Henriksen, H. C. B., Jørgensen, A. P., Bjørnebekk, A., Neupane, S. P., & Havnes, I. A. (2024) · Performance Enhancement & Health · doi:10.1016/j.peh.2024.100283 · Cited by 8 · see citing works

The Effect of Gonadotropin Withdrawal and Stimulation with Human Chorionic Gonadotropin on Intratesticular Androstenedione and DHEA in Normal Men

Roth, M. Y., Page, S. T., Lin, K., Anawalt, B. D., Matsumoto, A. M., Marck, B. T., Bremner, W. J., & Amory, J. K. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2518 · Cited by 8 · see citing works

Determination of Intraprostatic and Intratesticular Androgens

Šimková, M., Heráček, J., Drašar, P., & Hampl, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22010466 · Cited by 8 · see citing works

New frontiers in fertility preservation: a hypothesis on fertility optimization in men with hypergonadotrophic hypogonadism

Herati, A. S., Kohn, T. P., & Kassiri, B. (2020) · Translational Andrology and Urology · doi:10.21037/tau.2019.12.39 · Cited by 7 · see citing works

Physiologie der Hodenfunktion

Weinbauer, G. F., Luetjens, C. M., Simoni, M., & Nieschlag, E. (2009) · Springer eBooks · doi:10.1007/978-3-540-92963-5_2 · Cited by 8 · see citing works

Complete sperm suppression induced by dienogest plus testosterone undecanoate is associated with down-regulation in the expression of upstream steroidogenic enzyme genes in rat testis

Meena, R., Misro, M. M., Ghosh, D., & Nandan, D. (2012) · Contraception · doi:10.1016/j.contraception.2011.11.020 · Cited by 7 · see citing works

The Physiology of the Testis

Ilacqua, A., Francomano, D., & Aversa, A. (2016) · Endocrinology · doi:10.1007/978-3-319-27318-1_17-1 · Cited by 7 · see citing works

The Leydig Cell as a Target for Male Contraception

Luetjens, C. M., Wistuba, J., Weinbauer, G. F., & Nieschlag, E. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-453-7_29 · Cited by 7 · see citing works

Testicular fine-needle aspiration for the assessment of intratesticular hormone concentrations

Anawalt, B., Lee, A., Roth, M. Y., Nya‐Ngatchou, J. J., Lin, K., Walsh, T., Page, S., Matsumoto, A. M., Bremner, W., & Amory, J. K. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.156637 · Cited by 6 · see citing works

Treatment of idiopathic oligozoospermia with combined human chorionic gonadotropin/human menopausal gonadotrophin: A randomised, double‐blinded, placebo‐controlled clinical study

Zhao, N., Lu, X., Li, J., & Zhang, J. (2019) · Andrologia · doi:10.1111/and.13271 · Cited by 6 · see citing works

Medication patterns and fertility rates in a cohort of anabolic steroid users

Avant, R., Charchenko, C. M., Alom, M., Westerman, M. E., Maldonado, F., Miest, T. S., & Trost, L. W. (2018) · Translational Andrology and Urology · doi:10.21037/tau.2018.05.05 · Cited by 6 · see citing works

Spermatogenesis in a Prepubertal Boy

O'Grady, M. J., McGrath, N., Quinn, F. M. J., Capra, M. L., McDermott, M. B., & Murphy, N. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.03.040 · Cited by 6 · see citing works

Testosterone and male rejuvenation

Helo, S., Thomas, P., & Tadros, N. N. (2019) · Panminerva Medica · doi:10.23736/s0031-0808.18.03513-9 · Cited by 5 · see citing works

Synthetic androgens for male contraception

Page, S. T. (2024) · Contraception · doi:10.1016/j.contraception.2024.110735 · Cited by 5 · see citing works

Potential Parameters in Assessment of Testicular Toxicity

Gupta, P. C. (2018) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2018.07.001504 · Cited by 5 · see citing works

Endocrinopathies

Haywood, S., Lam, I., Laborde, E. L., & Brannigan, R. E. (2020) · Springer eBooks · doi:10.1007/978-3-030-32300-4_5 · Cited by 5 · see citing works

Oral administration of VDAC1-derived small molecule peptides increases circulating testosterone levels in male rats

Martinez-Arguelles, D. B., Nedow, J., Gukasyan, H. J., & Papadopoulos, V. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1003017 · Cited by 5 · see citing works

Early Pharmacologic Approaches to Avert Anabolic Steroid-induced Male Infertility: A Narrative Review

Rizzuti, A., Alvarenga, C., Stocker, G., Fraga, L., & Santos, H. O. (2023) · Clinical Therapeutics · doi:10.1016/j.clinthera.2023.09.003 · Cited by 5 · see citing works

Effects of testosterone and gonadotropin therapy in men with hypogonadotropic hypogonadism.

Farshchi, H. R., Shahnazi, A., & Azizi, F. (2009) · Intern J Endocrinol Metab · Cited by 5 · see citing works

Testosterone Replacement, Where Are We in 2025?

Walia, A., Coady, P. J., Sofia‐Hernandez, B., Gudlavalleti, H., El-Achkar, A., Dunnam, S. E., Madhusoodanan, V., Kohn, T. P., & Khera, M. (2025) · Trends in Urology & Men s Health · doi:10.1002/tre.70016 · Cited by 4 · see citing works

Sexual dysfunctions in male patients with infertility: recommendations from the Fifth International Consultation for Sexual Medicine (ICSM 2024)

Shin, D., Sansone, A., Krishnappa, P., Baazeem, A., Bernie, H. L., Ahsan, M. S., Thirumavalavan, N., Hellstrom, W. J. G., & Shah, R. S. (2025) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeaf073 · Cited by 6 · see citing works

Testosterone supplementation in men

Owen, R. C., Elkelany, O. O., & Kim, E. D. (2015) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000192 · Cited by 4 · see citing works

Dose-Dependent Increase in Intratesticular Testosterone by Very Low-Dose Human Chorionic Gonadotropin in Normal Men with Experimental Gonadotropin Deficiency

Roth, M. Y., Page, S. T., Lin, K., Anawalt, B. D., Matsumoto, A. M., Snyder, C. N., Marck, B. T., Bremner, W. J., & Amory, J. K. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0360 · Cited by 64 · see citing works

Low Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men following Gonadotropin Suppression

Coviello, A. D., Herbst, K. L., Amory, J. K., Anawalt, B. D., Sutton, P. L., Wright, W. W., Brown, T. R., Yan, X., Bremner, W. J., Matsumoto, A. M., et al. (2001) · Journal of Investigative Medicine · doi:10.1177/108155890105201s119

Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin

Amory, J. K., Coviello, A. D., Page, S. T., Anawalt, B. D., Matsumoto, A. M., & Bremner, W. J. (2007) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.02.059 · Cited by 42 · see citing works

(093) The Continued Use of Testosterone Does Not Interfere with Human Chorionic Gonadotropin-Mediated Return of Spermatogenesis

Kassab, J., Keeme-Sayre, A. G., Lindsey, J., Torres-Anguiano, J. R., Garcia, T., & Lipshultz, L. I. (2024) · The Journal of Sexual Medicine · doi:10.1093/jsxmed/qdae001.089

Stimulation of Sperm Production by Human Chorionic Gonadotropin after Prolonged Gonadotropin Suppression in Normal Men

Matsumoto, A. M., & Bremner, W. J. (1985) · Journal of Andrology · doi:10.1002/j.1939-4640.1985.tb00829.x · Cited by 50 · see citing works