The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hypothalamic-Pituitary Dysfunction after Irradiation of Nonpituitary Brain Tumors in Adults
Open accessAbstract
Context: Hypothalamic-pituitary (HP) dysfunction is common in children treated with cranial radiotherapy (RT) for brain tumors, but there is little known about the risk of HP dysfunction in adults treated with RT for primary nonpituitary brain tumors. Objective: The objective was to study the frequency of HP dysfunction in adults after RT for nonpituitary brain tumors. Method: We studied 56 adult patients who received external beam RT for primary nonpituitary brain tumors at time intervals of 12–150 months after RT. The control group consisted of 20 RT-naive patients with primary brain tumors. GH and adrenal axes were assessed using the insulin tolerance test or the glucagon stimulation test. Gonadotroph, thyrotroph, and lactotroph function were assessed using baseline blood measurements. The biological effective dose (BED) to the HP axis was calculated in the RT patients. Results: Hypopituitarism was present in 41% of patients. The frequency of GH, ACTH, gonadotropin, and TSH deficiencies, and hyperprolactinemia was 32, 21, 27, 9, and 32%, respectively. Any degree of hypopituitarism and GH deficiency was significantly associated with longer time interval from RT and greater BED. However, gonadotropin deficiency and hyperprolactinemia were only related to BED, whereas ACTH deficiency was only significantly associated with the time interval from RT. One RT-naive patient was GH deficient. Conclusion: Adult patients treated with cranial irradiation for primary nonpituitary brain tumors are at high risk of hypopituitarism, which is time and dose dependent. Long-term surveillance and periodic evaluation are needed. We recommend that adult late effect clinics, similar to those for children, should be established.
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Cites
Hypothalamic-pituitary dysfunction after radiation for brain tumors
Constine, L. S., Woolf, P. D., Cann, D., Mick, G., McCormick, K., Raubertas, R. F., & Rubin, P. (1993) · New England Journal of Medicine · doi:10.1056/nejm199301143280203 · Cited by 619
Hypopituitarism Following External Radiotherapy for Pituitary Tumours in Adults
LITTLEY, M. D., SHALET, S. M., BEARDWELL, C. G., AHMED, S. R., APPLEGATE, G., & SUTTON, M. L. (1989) · QJM: An International Journal of Medicine · doi:10.1093/oxfordjournals.qjmed.a068308 · Cited by 444
A RATIONAL APPROACH FOR ASSESSING THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS
Stewart, P. M., Seckl, J. R., Corrie, J., Edwards, C. R. W., & Padfield, P. L. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92020-x · Cited by 418
Anterior Pituitary Dysfunction in Survivors of Traumatic Brain Injury
Agha, A., Rogers, B., Sherlock, M., O’Kelly, P., Tormey, W., Phillips, J., & Thompson, C. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0511 · Cited by 390
Self-citationDiagnosis of growth-hormone deficiency in adults
Hoffman, D. M., O'Sullivan, A. J., Ho, K. K. Y., & Baxter, R. C. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90181-3 · Cited by 386
Leong, K. S., Walker, A. B., Martin, I., Wile, D., Wilding, J., & MacFarlane, I. A. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01169.x · Cited by 140
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Clayton, R. N. (1996) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1996.666478.x · Cited by 71
The Pituitary Megatest: Outdated?
Burke, C. W. (1992) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1992.tb00946.x · Cited by 50
Cited by
Stewart, F. A., Akleyev, A. V., Hauer-Jensen, M., Hendry, J. H., Kleiman, N. J., MacVittie, T. J., Aleman, B. M., Edgar, A. B., Mabuchi, K., Muirhead, C. R., et al. (2012) · Annals of the ICRP · doi:10.1016/j.icrp.2012.02.001 · Cited by 1,604
Mortality in Patients with Pituitary Disease
Sherlock, M., Ayuk, J., Tomlinson, J. W., Toogood, A. A., Aragon-Alonso, A., Sheppard, M. C., Bates, A. S., & Stewart, P. M. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0033 · Cited by 392
Self-citationSchneider, H. J., Aimaretti, G., Kreitschmann-Andermahr, I., Stalla, G.-K., & Ghigo, E. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60673-4 · Cited by 336
Appelman-Dijkstra, N. M., Kokshoorn, N. E., Dekkers, O. M., Neelis, K. J., Biermasz, N. R., Romijn, J. A., Smit, J. W. A., & Pereira, A. M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0306 · Cited by 162
Mortality in adults with hypopituitarism: a systematic review and meta-analysis
Jasim, S., Alahdab, F., Ahmed, A. T., Tamhane, S., Prokop, L. J., Nippoldt, T. B., & Murad, M. H. (2017) · Endocrine · doi:10.1007/s12020-016-1159-3 · Cited by 112
Metadata
- Authors
- Agha, A., Sherlock, M., Brennan, S., O’Connor, S. A., O’Sullivan, E., Rogers, B., Faul, C., Rawluk, D., Tormey, W., & Thompson, C. J.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2005-12-01
- Volume
- 90
- Issue
- 12
- Pages
- 6355-6360
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2077788260
- Cited by
- 186
- References
- 9
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Agha, A., Sherlock, M., Brennan, S., O’Connor, S. A., O’Sullivan, E., Rogers, B., Faul, C., Rawluk, D., Tormey, W., & Thompson, C. J. (2005). Hypothalamic-Pituitary Dysfunction after Irradiation of Nonpituitary Brain Tumors in Adults. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2005-1525
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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